Selective disappearance of an axonal protein, 440-kDa ankyrinB, associated with neuronal degeneration induced by methylmercury

Journal of Neuroscience Research

Volumn 73, Issue 6, 2003, Pages 831-839

  Sakaue, Motoharu ^a   Takanaga, Hiromi ^a   Adachi, Tatsumi ^b   Hara, Shuntaro ^a   Kunimoto, Manabu ^a  

^a KITASATO UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

Author keywords

440 kDa ankyrinB; Cerebellar cells; GFAP; Methylmercury; Neurotoxicity; Primary culture; Rat; Tau

Indexed keywords

ANKYRIN; GLIAL FIBRILLARY ACIDIC PROTEIN; ISOPROTEIN; METHYLMERCURY; MICROTUBULE ASSOCIATED PROTEIN 2; TAU PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL VIABILITY; CEREBELLUM; DENDRITE; DOT HYBRIDIZATION; IMMUNOCYTOCHEMISTRY; MERCURIALISM; NERVE CELL DEGENERATION; NERVE FIBER; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

ANIMALS; ANIMALS, NEWBORN; ANKYRINS; AXONS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOBLOTTING; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; METHYLMERCURY COMPOUNDS; MICROTUBULE-ASSOCIATED PROTEINS; NERVE DEGENERATION; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; TIME FACTORS;

EID: 0041837508     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10715     Document Type: Article

References (17)

1. Atchison WD, Hare MF. 1994. Mechanisms of merhylmercury-induced neurotoxicity, FASEB J 8:622-629.
2. Bennett V, Baines AJ. 2001. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev 81: 1353-1392.
3. Billingsley ME, Kincaid RL. 1997. Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J 323;577-591.
4. Chang LW. 1977. Neurotoxic effects of mercury: a review. Environ Res 14:329-373.
5. Charleston JS, Bolender RP, Mottet NK, Body RL, Vahter ME, Burbacher TM. 1994. Increases in the number of reactive glia in the visual cortex of Macaca fascicularis following subclinical long-term methyl mercury exposure. Toxicol App] Pharmacol 129:196-206.
6. Clarkson TW. 1987. Metal toxicity in the central nervous system. Environ Health Perspect 75:59-64.
7. Davis J, Bennett V. 1983. Brain spectrin: isolation of subunits and formation of hybrids with erythrocyte spectrin subunits. J Biol Chem 258:7757-7766.
8. Harada K, Fukuda S, Kunimoto M, Yoshida K. 1997. Distribution of ankyrin isoforms and their proteolysis after ischemia and reperfusion in rat brain. J Neurochem 69:371-376.
9. B in neuritogenesis in human neuroblastoma NB-1 cells. FEBS Lett 357: 217-220.
10. B is targeted to the axons of rat cerebellar neurons. J Cell Biol 131:1821-1829.
11. B associated with neurite retraction. Neuroreport 6:2545-2548.
12. Kunimoto M, Otto E, Bennett V. 1991. A new 440 kDa isoform is the major ankyrin in neonatal rat brain. J Cell Biol 115:1319-1331.
13. Kunimoto M, Aoki Y, Shibata K, Miura T. 1992. Differential cytotoxic effects of methylmercury and organ tin compounds on mature and immature neuronal cells and non-neuronal cells in vitro. Toxicol In Vitro 4:349-355.
14. Litersky JM, Scott CW, Johnson GVM. 1993. Phosphorylation, calpain proteolysis and tubulin binding of recombinant tau isoforms. Brain Res 604:32-40.
15. O'Callaghan JP. 1991. Assessment of neurotoxicity: use of glial fibrillary acidic protein as a biomarker. Biomed Environ Sci 4:192-276.
16. Su M, Kakita A, Yamada M, Takahashi H, Ikuta F. 1996. Degeneration of the synaptic boutons of parallel fibers in rats treated with methylmercury: chronological observations. Neuropthology 16:172-177.
17. Tsubaki T, Takahashi H. 1986. Recent advances in Minamata disease studies. Tokyo: Kodansha Ltd. p 24-39.