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Volumn 7, Issue , 2012, Pages 4841-4848

Retraction: Preparation of bioactive interferon alpha-loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion (Int J Nanomedicine, (2012), 7, (4841-4848), 10.2147/IJN.S35502);Preparation of bioactive interferon alpha-loaded polysaccharide nanoparticles using a new approach of temperature-induced water phase/water-phase emulsion

Author keywords

Activity of interferon alpha 2b; Dextran; Interferon alpha 2b; Nanoparticles; Stability of interferon alpha 2b

Indexed keywords

ALPHA2B INTERFERON; MACROGOL; NANOPARTICLE; POLYSACCHARIDE;

EID: 84870343839     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S170339     Document Type: Erratum
Times cited : (4)

References (48)
  • 2
    • 0023574823 scopus 로고
    • Clinical evaluation of recombinant interferon alfa-2a (Roferon-A) in metastatic melanoma using two different schedules
    • Legha SS, Papadopoulos NE, Plager C, etal. Clinical evaluation of recombinant interferon alfa-2a (Roferon-A) in metastatic melanoma using two different schedules. J Clin Oncol. 1987;5:1240-1246.
    • (1987) J Clin Oncol , vol.5 , pp. 1240-1246
    • Legha, S.S.1    Papadopoulos, N.E.2    Plager, C.3
  • 3
    • 77956284096 scopus 로고    scopus 로고
    • Sustained long-term remissions with weekly interferon maintenance therapy in hairy cell leukemia
    • Ramakrishna R, Manoharan A. Sustained long-term remissions with weekly interferon maintenance therapy in hairy cell leukemia. Asia Pac J Clin Oncol. 2010;6:210-212.
    • (2010) Asia Pac J Clin Oncol , vol.6 , pp. 210-212
    • Ramakrishna, R.1    Manoharan, A.2
  • 4
    • 0030133437 scopus 로고    scopus 로고
    • The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B
    • Bayraktar Y, Koseoglu T, Somner C, etal. The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. J Viral Hepat. 1996;3:129-135.
    • (1996) J Viral Hepat , vol.3 , pp. 129-135
    • Bayraktar, Y.1    Koseoglu, T.2    Somner, C.3
  • 5
    • 0037452405 scopus 로고    scopus 로고
    • Stabilization of recombinant interferon-α by pegylation for encapsulation in PLGA microspheres
    • Diwan M, Park TG. Stabilization of recombinant interferon-α by pegylation for encapsulation in PLGA microspheres. Int J Pharm. 2003; 252:111-122.
    • (2003) Int J Pharm , vol.252 , pp. 111-122
    • Diwan, M.1    Park, T.G.2
  • 6
    • 0024410695 scopus 로고
    • Synthesis of gelatin microspheres containing interferon
    • Tabata Y, Ikada Y. Synthesis of gelatin microspheres containing interferon. Pharm Res. 1989;6:422-427.
    • (1989) Pharm Res , vol.6 , pp. 422-427
    • Tabata, Y.1    Ikada, Y.2
  • 7
    • 0032826719 scopus 로고    scopus 로고
    • Preparation and evaluation of once-a-day injectable microspheres of interferon alpha in rats
    • Yoshikawa Y, Komuta Y, Nishihara T, Itoh Y, Yoshikawa H, Takada K. Preparation and evaluation of once-a-day injectable microspheres of interferon alpha in rats. J Drug Target. 1999;6:449-461.
    • (1999) J Drug Target , vol.6 , pp. 449-461
    • Yoshikawa, Y.1    Komuta, Y.2    Nishihara, T.3    Itoh, Y.4    Yoshikawa, H.5    Takada, K.6
  • 8
    • 0027212413 scopus 로고
    • Interferon-gamma in starch microparticles: Nitric oxide-generating activity in vitro and antileishmanial effect in mice
    • Degling L, Stjänkvist P, Sjöolm I. Interferon-gamma in starch microparticles: nitric oxide-generating activity in vitro and antileishmanial effect in mice. Pharm Res. 1993;6:783-790.
    • (1993) Pharm Res , vol.6 , pp. 783-790
    • Degling, L.1    Stjänkvist, P.2    Sjöolm, I.3
  • 9
    • 0034863913 scopus 로고    scopus 로고
    • Prevention of structural perturbations and aggregation upon encapsulation of bovine serum albumin into poly(lactide-co-glycolide) microspheres using the solid-in-oil-in-water technique
    • Castellanos IJ, Cuadrado WL, Griebenow K. Prevention of structural perturbations and aggregation upon encapsulation of bovine serum albumin into poly(lactide-co-glycolide) microspheres using the solid-in-oil-in-water technique. J Pharm Pharmacol. 2001;53:1099-1107.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 1099-1107
    • Castellanos, I.J.1    Cuadrado, W.L.2    Griebenow, K.3
  • 10
    • 0028953583 scopus 로고
    • Protein release from poly(lactic-co-glycolic acid) microspheres: Protein stability problems
    • Lu W, Park TG. Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems. PDA J Pharm Sci Tech. 1995; 49:13-19.
    • (1995) PDA J Pharm Sci Tech , vol.49 , pp. 13-19
    • Lu, W.1    Park, T.G.2
  • 11
    • 0030039264 scopus 로고    scopus 로고
    • Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres
    • Uchida T, Yagi A, Oda Y, Nakada Y, Goto S. Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres. Chem Pharm Bull. 1996;44:235-236.
    • (1996) Chem Pharm Bull , vol.44 , pp. 235-236
    • Uchida, T.1    Yagi, A.2    Oda, Y.3    Nakada, Y.4    Goto, S.5
  • 12
    • 0031575558 scopus 로고    scopus 로고
    • Stability and release of bovine serum albumin encapsulated within poly(lactide-co-glycolide) microparticles
    • Crotts G, Park TG. Stability and release of bovine serum albumin encapsulated within poly(lactide-co-glycolide) microparticles. J Control Release. 1997;44:123-134.
    • (1997) J Control Release , vol.44 , pp. 123-134
    • Crotts, G.1    Park, T.G.2
  • 13
    • 0034601108 scopus 로고    scopus 로고
    • Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes
    • Lam XM, Duenas ET, Daugherty AL, Levin N, Cleland JL. Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes. J Control Release. 2000;67:281-292.
    • (2000) J Control Release , vol.67 , pp. 281-292
    • Lam, X.M.1    Duenas, E.T.2    Daugherty, A.L.3    Levin, N.4    Cleland, J.L.5
  • 14
    • 2142768756 scopus 로고    scopus 로고
    • Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres
    • Blanco-Príeto MJ, Campanero MA, Besseghir K, Heimgatner F, Gander B. Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres. J Control Release. 2004;96:437-448.
    • (2004) J Control Release , vol.96 , pp. 437-448
    • Blanco-Príeto, M.J.1    Campanero, M.A.2    Besseghir, K.3    Heimgatner, F.4    Gander, B.5
  • 15
    • 0037343587 scopus 로고    scopus 로고
    • Biodegradable micro and nanoparticles as long-term delivery vehicles for interferon-alpha
    • Sánchez A, Tobío M, González L, Fabra A, Alonso MJ. Biodegradable micro and nanoparticles as long-term delivery vehicles for interferon-alpha. Eur J Pharm Sci. 2003;18:221-229.
    • (2003) Eur J Pharm Sci , vol.18 , pp. 221-229
    • Sánchez, A.1    Tobío, M.2    González, L.3    Fabra, A.4    Alonso, M.J.5
  • 16
    • 0038445582 scopus 로고    scopus 로고
    • Biodegradable microspheres for protein delivery
    • Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J Control Release. 2003;90:261-280.
    • (2003) J Control Release , vol.90 , pp. 261-280
    • Sinha, V.R.1    Trehan, A.2
  • 17
    • 58149152977 scopus 로고    scopus 로고
    • Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion
    • Yuan W, Wu F, Guo M, Jin T. Development of protein delivery microsphere system by a novel S/O/O/W multi-emulsion. Eur J Pharm Sci. 2009;36:212-218.
    • (2009) Eur J Pharm Sci , vol.36 , pp. 212-218
    • Yuan, W.1    Wu, F.2    Guo, M.3    Jin, T.4
  • 18
    • 0037360403 scopus 로고    scopus 로고
    • Precipitation of lysozyme nanoparticles from dimethyl sulfoxide using carbon dioxide as antisolvent
    • Muhrer G, Mazzotti M. Precipitation of lysozyme nanoparticles from dimethyl sulfoxide using carbon dioxide as antisolvent. Biotechnol Prog. 2003;19:549-556.
    • (2003) Biotechnol Prog , vol.19 , pp. 549-556
    • Muhrer, G.1    Mazzotti, M.2
  • 19
    • 70349406574 scopus 로고    scopus 로고
    • Formulating protein therapeutics into particulate forms
    • Yang S, Yuan W. Formulating protein therapeutics into particulate forms. Expert Opin Drug Deliv. 2009;6(10):1123-1133.
    • (2009) Expert Opin Drug Deliv , vol.6 , Issue.10 , pp. 1123-1133
    • Yang, S.1    Yuan, W.2
  • 20
    • 0141684517 scopus 로고    scopus 로고
    • Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network
    • Kim J, Grate JW. Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network. Nano Lett. 2003;3:1219-1222.
    • (2003) Nano Lett , vol.3 , pp. 1219-1222
    • Kim, J.1    Grate, J.W.2
  • 21
    • 0034495318 scopus 로고    scopus 로고
    • Protein spray-freeze drying. Effect of atomization conditions on particle size and stability
    • Costantino HR, Firouzabadian L, Hogeland K, etal. Protein spray-freeze drying. Effect of atomization conditions on particle size and stability. Pharm Res. 2000;17:1374-1383.
    • (2000) Pharm Res , vol.17 , pp. 1374-1383
    • Costantino, H.R.1    Firouzabadian, L.2    Hogeland, K.3
  • 22
    • 0037148656 scopus 로고    scopus 로고
    • Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery
    • Lavasanifar A, Samuel J, Kwon GS. Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery. Adv Drug Deliv Rev. 2002;54:169-190.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 169-190
    • Lavasanifar, A.1    Samuel, J.2    Kwon, G.S.3
  • 23
    • 34547899919 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as a drug delivery system for peptides and proteins
    • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev. 2007;59:478-490.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 478-490
    • Almeida, A.J.1    Souto, E.2
  • 24
    • 79959487372 scopus 로고    scopus 로고
    • Tailoring nanocarriers for intracellular protein delivery
    • Gu Z, Biswas A, Zhao M, Tang Y. Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev. 2011;40:3638-3655.
    • (2011) Chem Soc Rev , vol.40 , pp. 3638-3655
    • Gu, Z.1    Biswas, A.2    Zhao, M.3    Tang, Y.4
  • 25
    • 68849091330 scopus 로고    scopus 로고
    • Intracellular protein delivery by glucose-coated polymeric beads
    • Jung S, Huh S, Cheon YP, Park S. Intracellular protein delivery by glucose-coated polymeric beads. Chem Commun. 2009;33:5003-5005.
    • (2009) Chem Commun , vol.33 , pp. 5003-5005
    • Jung, S.1    Huh, S.2    Cheon, Y.P.3    Park, S.4
  • 26
    • 84858677127 scopus 로고    scopus 로고
    • Polymeric multilayer capsules for drug delivery
    • Koker SD, Hoogenboom R, Geest BGD. Polymeric multilayer capsules for drug delivery. Chem Soc Rev. 2012;41:2867-2884.
    • (2012) Chem Soc Rev , vol.41 , pp. 2867-2884
    • Koker, S.D.1    Hoogenboom, R.2    Geest, B.G.D.3
  • 27
    • 69749109617 scopus 로고    scopus 로고
    • Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers
    • Mukherjee B, Santra K, Pattnaik G, Ghosh S. Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. Int J Nanomedicine. 2008;3:487-496.
    • (2008) Int J Nanomedicine , vol.3 , pp. 487-496
    • Mukherjee, B.1    Santra, K.2    Pattnaik, G.3    Ghosh, S.4
  • 28
    • 84866747868 scopus 로고    scopus 로고
    • PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses
    • Ma W, Chen M, Kaushal S, etal. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses. Int J Nanomedicine. 2012;7:1475-1487.
    • (2012) Int J Nanomedicine , vol.7 , pp. 1475-1487
    • Ma, W.1    Chen, M.2    Kaushal, S.3
  • 29
    • 84858848564 scopus 로고    scopus 로고
    • Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model
    • Binsalamah ZM, Paul A, Khan AA, Prakash S, Shum-Tim D. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model. Int J Nanomedicine. 2011;6:2667-2678.
    • (2011) Int J Nanomedicine , vol.6 , pp. 2667-2678
    • Binsalamah, Z.M.1    Paul, A.2    Khan, A.A.3    Prakash, S.4    Shum-Tim, D.5
  • 30
    • 80155194439 scopus 로고    scopus 로고
    • Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds
    • Tan Q, Tang H, Hu J, etal. Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds. Int J Nanomedicine. 2011;6:929-942.
    • (2011) Int J Nanomedicine , vol.6 , pp. 929-942
    • Tan, Q.1    Tang, H.2    Hu, J.3
  • 31
    • 34748867725 scopus 로고    scopus 로고
    • Novel approaches in microparticulate PLGA delivery systems encapsulating proteins
    • Taluja A, Youn YS, Bae YH. Novel approaches in microparticulate PLGA delivery systems encapsulating proteins. J Mater Chem. 2007;17: 4002-4014.
    • (2007) J Mater Chem , vol.17 , pp. 4002-4014
    • Taluja, A.1    Youn, Y.S.2    Bae, Y.H.3
  • 32
    • 77957769007 scopus 로고    scopus 로고
    • Controllable protein delivery from coated surgical sutures
    • Lee JS, Lu Y, Baer GS, Markel MD, Murphy WL. Controllable protein delivery from coated surgical sutures. J Mater Chem. 2010;20:8894-8903.
    • (2010) J Mater Chem , vol.20 , pp. 8894-8903
    • Lee, J.S.1    Lu, Y.2    Baer, G.S.3    Markel, M.D.4    Murphy, W.L.5
  • 33
    • 84858033200 scopus 로고    scopus 로고
    • Sol-gel transition of PEG-PAF aqueous solution and its application for hGH sustained release
    • Shinde UP, Joo MK, Moon HJ, Jeong B. Sol-gel transition of PEG-PAF aqueous solution and its application for hGH sustained release. J Mater Chem. 2012;22:6072-6079.
    • (2012) J Mater Chem , vol.22 , pp. 6072-6079
    • Shinde, U.P.1    Joo, M.K.2    Moon, H.J.3    Jeong, B.4
  • 34
    • 79551648100 scopus 로고    scopus 로고
    • Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles
    • Ren T, Yuan W, Zhao H, Jin T. Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles. Micro and Nano Lett. 2011; 6 (2):70-74.
    • (2011) Micro and Nano Lett , vol.6 , Issue.2 , pp. 70-74
    • Ren, T.1    Yuan, W.2    Zhao, H.3    Jin, T.4
  • 35
    • 84863032547 scopus 로고    scopus 로고
    • Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres
    • Yuan W, Liu Z. Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres. Int J Nanomedicine. 2012;7:257-270.
    • (2012) Int J Nanomedicine , vol.7 , pp. 257-270
    • Yuan, W.1    Liu, Z.2
  • 36
    • 84862592012 scopus 로고    scopus 로고
    • Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor
    • Yuan W, Liu Z. Surgical wound healing using hemostatic gauze scaffold loaded with nanoparticles containing sustained-release granulocyte colony-stimulating factor. Int J Nanomedicine. 2011;6:3139-3149.
    • (2011) Int J Nanomedicine , vol.6 , pp. 3139-3149
    • Yuan, W.1    Liu, Z.2
  • 37
    • 42749093836 scopus 로고    scopus 로고
    • Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents
    • Jin T, Zhu J, Wu F, Yuan W, Geng LL, Zhu H. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J Control Release. 2008;128:50-59.
    • (2008) J Control Release , vol.128 , pp. 50-59
    • Jin, T.1    Zhu, J.2    Wu, F.3    Yuan, W.4    Geng, L.L.5    Zhu, H.6
  • 39
    • 0021985030 scopus 로고
    • Characteristics of antiviral and anticellular activities of human recombinant interferon-gamma
    • Gomi K, Morimoto M, Nakamizo N. Characteristics of antiviral and anticellular activities of human recombinant interferon-gamma. Jpn J Cancer Res. 1985;76:224-234.
    • (1985) Jpn J Cancer Res , vol.76 , pp. 224-234
    • Gomi, K.1    Morimoto, M.2    Nakamizo, N.3
  • 40
    • 0029859532 scopus 로고    scopus 로고
    • Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres
    • Cleland JL, Jones JS. Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres. Pharm Res. 1996;13:1464-1475.
    • (1996) Pharm Res , vol.13 , pp. 1464-1475
    • Cleland, J.L.1    Jones, J.S.2
  • 41
    • 0034854492 scopus 로고    scopus 로고
    • Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation
    • Breen ED, Curley JG, Overcashier DE, Hsu CC, Shire SJ. Effect of moisture on the stability of a lyophilized humanized monoclonal antibody formulation. Pharm Res. 2001;18:1345-1353.
    • (2001) Pharm Res , vol.18 , pp. 1345-1353
    • Breen, E.D.1    Curley, J.G.2    Overcashier, D.E.3    Hsu, C.C.4    Shire, S.J.5
  • 42
    • 0030929864 scopus 로고    scopus 로고
    • Dependence of the molecular mobility and protein stability of freeze-dried gamma-globulin formulations on the molecular weight of dextran
    • Yoshioka S, Aso Y, Kojima S. Dependence of the molecular mobility and protein stability of freeze-dried gamma-globulin formulations on the molecular weight of dextran. Pharm Res. 1997;14:736-741.
    • (1997) Pharm Res , vol.14 , pp. 736-741
    • Yoshioka, S.1    Aso, Y.2    Kojima, S.3
  • 43
    • 34250874458 scopus 로고    scopus 로고
    • Preparation of dextran glassy particles through freezing-induced phase separation
    • Yuan W, Wu F, Geng Y, Xu S, Jin T. Preparation of dextran glassy particles through freezing-induced phase separation. Int J Pharm. 2007;339(1-2): 76-83.
    • (2007) Int J Pharm , vol.339 , Issue.1-2 , pp. 76-83
    • Yuan, W.1    Wu, F.2    Geng, Y.3    Xu, S.4    Jin, T.5
  • 44
    • 57849112227 scopus 로고    scopus 로고
    • Preparation of polysaccharide glassy microparticles with stabilization of proteins
    • Yuan W, Geng Y, Wu F, etal. Preparation of polysaccharide glassy microparticles with stabilization of proteins. Int J Pharm. 2009; 366:154-159.
    • (2009) Int J Pharm , vol.366 , pp. 154-159
    • Yuan, W.1    Geng, Y.2    Wu, F.3
  • 45
    • 84867511009 scopus 로고    scopus 로고
    • Micro and nanotechnology for intracellular delivery therapy protein
    • Xu D, Hu A, Su J, Wu F, Yuan W. Micro and nanotechnology for intracellular delivery therapy protein. Nano-Micro Lett. 2012;4:118-123.
    • (2012) Nano-Micro Lett , vol.4 , pp. 118-123
    • Xu, D.1    Hu, A.2    Su, J.3    Wu, F.4    Yuan, W.5
  • 46
    • 33947097979 scopus 로고    scopus 로고
    • An effective approach to prepare uniform protein-Zn2+ nanoparticles under mild conditions
    • Yuan W, Wu F, Geng Y, Xu S, Jin, T. An effective approach to prepare uniform protein-Zn2+ nanoparticles under mild conditions. Nanotechnology. 2007;18 (14): no. 145601.
    • (2007) Nanotechnology. , vol.18 , Issue.14 , pp. 145601
    • Yuan, W.1    Wu, F.2    Geng, Y.3    Xu, S.4    Jin, T.5
  • 47
    • 77953916062 scopus 로고    scopus 로고
    • Preparation of protein-loaded sustained-release microspheres via 'solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E)' emulsification
    • Yuan W, Zhang Y, Wu F, et al. Preparation of protein-loaded sustained-release microspheres via 'solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E)' emulsification. Colloids Surf B Biointerfaces. 2010;79(2):326-333.
    • (2010) Colloids Surf B Biointerfaces. , vol.79 , Issue.2 , pp. 326-333
    • Yuan, W.1    Zhang, Y.2    Wu, F.3
  • 48
    • 79959623710 scopus 로고    scopus 로고
    • Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats
    • Rong X, Mo X, Ren T, et al. Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. Eur J Pharm Sci. 2011;43(4):334-342.
    • (2011) Eur J Pharm Sci , vol.43 , Issue.4 , pp. 334-342
    • Rong, X.1    Mo, X.2    Ren, T.3


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