Preparation of protein-loaded sustained-release microspheres via 'solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E)' emulsification

Colloids and Surfaces B: Biointerfaces

Volumn 79, Issue 2, 2010, Pages 326-333

  Yuan, Weien ^a   Zhang, Yulong ^a   Wu, Fei ^a   Li, Hui ^a   Cai, Yunpeng ^a   Zhang, Yuankuei ^a   Han, Mingjia ^a   Jin, Tuo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Microspheres; Polysaccharide particles; Protein stability; S O hO E; Sustained release

Indexed keywords

BOVINE SERUM ALBUMINS; CONTACT WATER; CONTINUOUS PHASE; CONTROLLED RELEASE; ENCAPSULATION EFFICIENCY; ENZYMATIC ACTIVITIES; GALACTOPYRANOSIDE; GALACTOSIDASES; HYDROPHOBIC POLYMERS; HYDROPHOBIC SOLUTIONS; LOADING EFFICIENCY; ORGANIC SOLUTIONS; POLY-LACTIDE-CO-GLYCOLIDE; POLYVINYL ALCOHOL SOLUTION; PROTEIN PARTICLES; PROTEIN STABILITY; RELEASE KINETICS; S/O/HO/E; SEC-HPLC; SOLID PARTICLES; SUSTAINED-RELEASE;

BODY FLUIDS; DISSOLUTION; EMULSIFICATION; ENCAPSULATION; ETHANOL; ETHYLENE; ETHYLENE GLYCOL; GLYCEROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; HYDROPHOBICITY; MICROSPHERES; ORGANIC POLYMERS; PACKAGING; PROTEINS; SIZE EXCLUSION CHROMATOGRAPHY; SURFACE ACTIVE AGENTS; SURFACE TENSION;

PHASE INTERFACES;

4 NITROPHENYLGALACTOSIDE; ALCOHOL; BETA GALACTOSIDASE; BOVINE SERUM ALBUMIN; ETHYLENE GLYCOL; GLYCEROL; MICROSPHERE; OIL; POLYGLACTIN; POLYMER; POLYVINYL ALCOHOL; SURFACTANT; WATER; DELAYED RELEASE FORMULATION; EMULSIFYING AGENT; LACTIC ACID; MYOGLOBIN; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PROTEIN;

AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DISPERSION; DISSOLUTION; DRUG ACTIVITY; EMULSION; ENZYME ASSAY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; HYDROPHILICITY; HYDROPHOBICITY; KINETICS; MACROMOLECULE; MICROENCAPSULATION; MOLECULAR STABILITY; PRIORITY JOURNAL; SOLID; SOLUBILITY; SURFACE TENSION; SUSTAINED RELEASE PREPARATION; VISCOSITY; ANIMAL; BOVINAE; CHEMISTRY; DELAYED RELEASE FORMULATION; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; METABOLISM; PARTICLE SIZE; PROTEIN QUATERNARY STRUCTURE; SCANNING ELECTRON MICROSCOPY; SYNTHESIS;

ANIMALS; BETA-GALACTOSIDASE; CATTLE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; EMULSIFYING AGENTS; ETHANOL; HORSES; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; MYOGLOBIN; OILS; PARTICLE SIZE; POLYGLYCOLIC ACID; PROTEIN STRUCTURE, QUATERNARY; PROTEINS; SERUM ALBUMIN, BOVINE; SURFACE-ACTIVE AGENTS;

BOVINAE;

EID: 77953916062     PISSN: 09277765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2010.04.004     Document Type: Article

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