메뉴 건너뛰기




Volumn 16, Issue 12, 2012, Pages 1566-1573

A rational vaccine pipeline for tuberculosis

Author keywords

Mycobacterium tuberculosis; Tuberculosis; Vaccines

Indexed keywords

BACTERIAL ANTIGEN; BCG VACCINE; DNA VACCINE; RECOMBINANT FUSION POLYPROTEIN VACCINE; UNCLASSIFIED DRUG;

EID: 84870329077     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.12.0569     Document Type: Review
Times cited : (37)

References (51)
  • 1
    • 67649236987 scopus 로고    scopus 로고
    • Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis
    • Xing Z, McFarland C T, Sallenave J M, Izzo A, Wang J, McMurray D N. Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis. PLoS ONE 2009; 4: e5856.
    • (2009) PLoS ONE , vol.4
    • Xing, Z.1    McFarland, C.T.2    Sallenave, J.M.3    Izzo, A.4    Wang, J.5    McMurray, D.N.6
  • 2
    • 9144267735 scopus 로고    scopus 로고
    • Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans
    • McShane H, Pathan A A, Sander C R, et al. Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nat Med 2004; 10: 1240-1244.
    • (2004) Nat Med , vol.10 , pp. 1240-1244
    • McShane, H.1    Pathan, A.A.2    Sander, C.R.3
  • 3
    • 77951826915 scopus 로고    scopus 로고
    • The novel TB vaccine, AERAS-402, induces robust and polyfunctional CD4 and CD8 T cells in adults
    • Abel B, Tameris M, Mansoor N, et al. The novel TB vaccine, AERAS-402, induces robust and polyfunctional CD4 and CD8 T cells in adults. Am J Respir Crit Care Med 2010; 181: 1407-1417.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1407-1417
    • Abel, B.1    Tameris, M.2    Mansoor, N.3
  • 4
    • 78649758720 scopus 로고    scopus 로고
    • Syringe free vaccination with CAF01 adjuvated Ag85B-ESAT-6 in bioneedles provides strong and prolonged protection against tuberculosis
    • Christensen D, Lindenstrom T, van de Wijdeven G, Andersen P, Agger E M. Syringe free vaccination with CAF01 adjuvated Ag85B-ESAT-6 in bioneedles provides strong and prolonged protection against tuberculosis. PLoS ONE 2010; 5: e15043.
    • (2010) PLoS ONE , vol.5
    • Christensen, D.1    Lindenstrom, T.2    Van De Wijdeven, G.3    Andersen, P.4    Agger, E.M.5
  • 5
    • 78449242585 scopus 로고    scopus 로고
    • Evaluation of the safety and immunogenicity of two antigen concentrations of the M. tuberculosis 72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults
    • Leroux-Roels I, Leroux-Roels G, Ofori-Anyinam O, et al. Evaluation of the safety and immunogenicity of two antigen concentrations of the M. tuberculosis 72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults. Clin Vaccine Immunol 2010; 17: 1763-1771.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 1763-1771
    • Leroux-Roels, I.1    Leroux-Roels, G.2    Ofori-Anyinam, O.3
  • 6
    • 67649961505 scopus 로고    scopus 로고
    • Protection and polyfunctional T-cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose
    • Aagaard C, Hoang T T, Izzo A, et al. Protection and polyfunctional T-cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose. PLoS ONE 2009; 4: e5930.
    • (2009) PLoS ONE , vol.4
    • Aagaard, C.1    Hoang, T.T.2    Izzo, A.3
  • 7
    • 79951811069 scopus 로고    scopus 로고
    • Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T-cell responses in volunteers with previous BCG vaccination or tuberculosis infection
    • van Dissel J T, Soonawala D, Joosten S A, et al. Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T-cell responses in volunteers with previous BCG vaccination or tuberculosis infection. Vaccine 2011; 29: 2100-2109.
    • (2011) Vaccine , vol.29 , pp. 2100-2109
    • Van Dissel, J.T.1    Soonawala, D.2    Joosten, S.A.3
  • 8
    • 84855467363 scopus 로고    scopus 로고
    • The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection
    • Lin P L, Dietrich J, Tan E, et al. The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection. J Clin Invest 2011; 122: 303-314.
    • (2011) J Clin Invest , vol.122 , pp. 303-314
    • Lin, P.L.1    Dietrich, J.2    Tan, E.3
  • 9
    • 71849091759 scopus 로고    scopus 로고
    • Identification of human T-cell antigens for the development of vaccines against Mycobacterium tuberculosis
    • Bertholet S, Ireton G C, Kahn M, et al. Identification of human T-cell antigens for the development of vaccines against Mycobacterium tuberculosis. J Immunol 2008; 181: 7948-7957.
    • (2008) J Immunol , vol.181 , pp. 7948-7957
    • Bertholet, S.1    Ireton, G.C.2    Kahn, M.3
  • 10
    • 80054745408 scopus 로고    scopus 로고
    • Recombinant BCG ΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses
    • Desel C, Dorhoi A, Bandermann S, Grode L, Eisele B, Kaufmann S H. Recombinant BCG ΔureC hly+ induces superior protection over parental BCG by stimulating a balanced combination of type 1 and type 17 cytokine responses. J Infect Dis 2011; 204: 1573-1584.
    • (2011) J Infect Dis , vol.204 , pp. 1573-1584
    • Desel, C.1    Dorhoi, A.2    Bandermann, S.3    Grode, L.4    Eisele, B.5    Kaufmann, S.H.6
  • 11
    • 74249084926 scopus 로고    scopus 로고
    • Double-blind, randomized, placebo-controlled phase I clinical trial of the therapeutical antituberculous vaccine RUTI
    • Vilaplana C, Montane E, Pinto S, et al. Double-blind, randomized, placebo-controlled phase I clinical trial of the therapeutical antituberculous vaccine RUTI. Vaccine 2010; 28: 1106-1116.
    • (2010) Vaccine , vol.28 , pp. 1106-1116
    • Vilaplana, C.1    Montane, E.2    Pinto, S.3
  • 12
    • 0036021975 scopus 로고    scopus 로고
    • Effect of an immunomodulator containing Mycobacterium w on sputum conversion in pulmonary tuberculosis
    • Patel N, Deshpande M M, Shah M. Effect of an immunomodulator containing Mycobacterium w on sputum conversion in pulmonary tuberculosis. J Indian Med Assoc 2002; 100: 191-193.
    • (2002) J Indian Med Assoc , vol.100 , pp. 191-193
    • Patel, N.1    Deshpande, M.M.2    Shah, M.3
  • 13
    • 84871363074 scopus 로고    scopus 로고
    • World Health Organization. Geneva, Switzerland: WHO, Accessed September 2012
    • Stop TB Partnership Working Group, World Health Organization. New TB vaccines. Geneva, Switzerland: WHO, 2011. http://www.stoptb.org/wg/new-vaccines/ assets/documents/TB%20Vaccine%20Pipeline-rAug%202012.pdf Accessed September 2012.
    • (2011) New TB Vaccines
  • 14
    • 78650240549 scopus 로고    scopus 로고
    • Prospects for a new, safer and more effective TB vaccine
    • Hawkridge T, Mahomed H. Prospects for a new, safer and more effective TB vaccine. Paediatr Respir Rev 2011; 12: 46-51.
    • (2011) Paediatr Respir Rev , vol.12 , pp. 46-51
    • Hawkridge, T.1    Mahomed, H.2
  • 15
    • 84863690353 scopus 로고    scopus 로고
    • Vaccines against tuberculosis: Where are we and where do we need to go?
    • Ottenhoff T H, Kaufmann S H. Vaccines against tuberculosis: where are we and where do we need to go? PLoS Pathog 2012; 8: e1002607.
    • (2012) PLoS Pathog , vol.8
    • Ottenhoff, T.H.1    Kaufmann, S.H.2
  • 16
    • 84856712789 scopus 로고    scopus 로고
    • Taskforce on clinical research issues STPWGoTV. Consensus statement on diagnostic end points for infant tuberculosis vaccine trials
    • Hatherill M, Verver S, Mahomed H. Taskforce on clinical research issues STPWGoTV. Consensus statement on diagnostic end points for infant tuberculosis vaccine trials. Clin Infect Dis 2012; 54: 493-501.
    • (2012) Clin Infect Dis , vol.54 , pp. 493-501
    • Hatherill, M.1    Verver, S.2    Mahomed, H.3
  • 17
    • 0026465216 scopus 로고
    • The antigen 85 complex: A major secretion product of Mycobacterium tuberculosis
    • Wiker H G, Harboe M. The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis. Microbiol Rev 1992; 56: 648-661.
    • (1992) Microbiol Rev , vol.56 , pp. 648-661
    • Wiker, H.G.1    Harboe, M.2
  • 18
    • 0033966029 scopus 로고    scopus 로고
    • Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens
    • Skjot R L V, Oettinger T, Rosenkrands I, et al. Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens. Infect Immun 2000; 68: 214-220.
    • (2000) Infect Immun , vol.68 , pp. 214-220
    • Skjot, R.L.V.1    Oettinger, T.2    Rosenkrands, I.3
  • 19
    • 84863993689 scopus 로고    scopus 로고
    • ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria
    • Houben D, Demangel C, van Ingen J, et al. ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria. Cell Microbiol 2012; 14: 1287-1298.
    • (2012) Cell Microbiol , vol.14 , pp. 1287-1298
    • Houben, D.1    Demangel, C.2    Van Ingen, J.3
  • 20
    • 84858734598 scopus 로고    scopus 로고
    • Rational approach to selection and clinical development of TB vaccine candidates
    • Edinb
    • Barker L, Hessel L, Walker B. Rational approach to selection and clinical development of TB vaccine candidates. Tuberculosis (Edinb) 2012; 92 (Suppl 1): S25-S29.
    • (2012) Tuberculosis , vol.92 , Issue.SUPPL. 1
    • Barker, L.1    Hessel, L.2    Walker, B.3
  • 21
    • 84858997919 scopus 로고    scopus 로고
    • Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis
    • Brennan M J, Clagett B, Fitzgerald H, et al. Preclinical evidence for implementing a prime-boost vaccine strategy for tuberculosis. Vaccine 2012; 30 (18): 2811-2823.
    • (2012) Vaccine , vol.30 , Issue.18 , pp. 2811-2823
    • Brennan, M.J.1    Clagett, B.2    Fitzgerald, H.3
  • 22
    • 2942596008 scopus 로고    scopus 로고
    • Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, M. tuberculosis 72F, delivered as naked DNAor recombinant protein
    • Skeiky Y A W, Alderson M R, Ovendale P J, et al. Differential immune responses and protective efficacy induced by components of a tuberculosis polyprotein vaccine, M. tuberculosis 72F, delivered as naked DNAor recombinant protein. J Immunol 2004; 172: 7618-7628.
    • (2004) J Immunol , vol.172 , pp. 7618-7628
    • Skeiky, Y.A.W.1    Alderson, M.R.2    Ovendale, P.J.3
  • 23
    • 20844439411 scopus 로고    scopus 로고
    • Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    • Tsenova L, Ellison E, Harbacheuski R, et al. Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli. J Infect Dis 2005; 192: 98-106.
    • (2005) J Infect Dis , vol.192 , pp. 98-106
    • Tsenova, L.1    Ellison, E.2    Harbacheuski, R.3
  • 24
    • 0141669013 scopus 로고    scopus 로고
    • Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection
    • Capuano S V III, Croix D A, Pawar S, et al. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect Immun 2003; 71: 5831-5844.
    • (2003) Infect Immun , vol.71 , pp. 5831-5844
    • Capuano III, S.V.1    Croix, D.A.2    Pawar, S.3
  • 25
    • 79960221692 scopus 로고    scopus 로고
    • Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis
    • Edinb
    • Dharmadhikari A S, Basaraba R J, Van Der Walt M L, et al. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. Tuberculosis (Edinb) 2011; 91: 329-338.
    • (2011) Tuberculosis , vol.91 , pp. 329-338
    • Dharmadhikari, A.S.1    Basaraba, R.J.2    Van Der Walt, M.L.3
  • 26
    • 79955790005 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia
    • Ameni G, Vordermeier M, Firdessa R, et al. Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia. Vet J 2011; 188: 359-361.
    • (2011) Vet J , vol.188 , pp. 359-361
    • Ameni, G.1    Vordermeier, M.2    Firdessa, R.3
  • 27
    • 84858718283 scopus 로고    scopus 로고
    • Creativity in tuberculosis research and discovery
    • Edinb
    • Young D, Verreck F A W. Creativity in tuberculosis research and discovery. Tuberculosis (Edinb) 2012; 92 (Suppl 1): S14-S16.
    • (2012) Tuberculosis , vol.92 , Issue.SUPPL. 1
    • Young, D.1    Verreck, F.A.W.2
  • 28
    • 84863393669 scopus 로고    scopus 로고
    • A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin
    • Minassian A M, Satti I, Poulton I D, Meyer J, Hill A V, McShane H. A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin. J Infect Dis 2012; 205: 1035-1042.
    • (2012) J Infect Dis , vol.205 , pp. 1035-1042
    • Minassian, A.M.1    Satti, I.2    Poulton, I.D.3    Meyer, J.4    Hill, A.V.5    McShane, H.6
  • 29
    • 0032958395 scopus 로고    scopus 로고
    • Clinical reactogenicity of intradermal bacille Calmette-Guerin vaccination
    • Hoft D F, Leonardi C, Milligan T, et al. Clinical reactogenicity of intradermal bacille Calmette-Guerin vaccination. Clin Infect Dis 1999; 28: 785-790.
    • (1999) Clin Infect Dis , vol.28 , pp. 785-790
    • Hoft, D.F.1    Leonardi, C.2    Milligan, T.3
  • 31
    • 0035849873 scopus 로고    scopus 로고
    • The heparin-binding haemagglutinin of M. tuberculosis is required for extra-pulmonary dissemination
    • Pethe K, Alonso S, Biet F, et al. The heparin-binding haemagglutinin of M. tuberculosis is required for extra-pulmonary dissemination. Nature 2001; 412: 190-194.
    • (2001) Nature , vol.412 , pp. 190-194
    • Pethe, K.1    Alonso, S.2    Biet, F.3
  • 32
    • 4644324023 scopus 로고    scopus 로고
    • Methylation-dependent T-cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin
    • Temmerman S, Pethe K, Parra M, et al. Methylation-dependent T-cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin. Nat Med 2004; 10: 935-941.
    • (2004) Nat Med , vol.10 , pp. 935-941
    • Temmerman, S.1    Pethe, K.2    Parra, M.3
  • 33
    • 70349759312 scopus 로고    scopus 로고
    • Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis
    • Rouanet C, Debrie A S, Lecher S, Locht C. Subcutaneous boosting with heparin binding haemagglutinin increases BCG-induced protection against tuberculosis. Microbes Infect 2009; 11: 995-1001.
    • (2009) Microbes Infect , vol.11 , pp. 995-1001
    • Rouanet, C.1    Debrie, A.S.2    Lecher, S.3    Locht, C.4
  • 34
    • 61949216736 scopus 로고    scopus 로고
    • Effector-memory T-cell responses are associated with protection of rhesus monkeys from mucosal SIV challenge
    • Hansen S G, Vieville C, Whizin N, et al. Effector-memory T-cell responses are associated with protection of rhesus monkeys from mucosal SIV challenge. Nat Med 2009; 15: 293-299.
    • (2009) Nat Med , vol.15 , pp. 293-299
    • Hansen, S.G.1    Vieville, C.2    Whizin, N.3
  • 35
    • 79957618772 scopus 로고    scopus 로고
    • Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
    • Hansen S G, Ford J C, Lewis M S, et al. Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 2011; 473: 523-527.
    • (2011) Nature , vol.473 , pp. 523-527
    • Hansen, S.G.1    Ford, J.C.2    Lewis, M.S.3
  • 36
    • 84855372641 scopus 로고    scopus 로고
    • Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species
    • Colloca S, Barnes E, Folgori A, et al. Vaccine vectors derived from a large collection of simian adenoviruses induce potent cellular immunity across multiple species. Sci Transl Med 2012; 4: 115ra2.
    • (2012) Sci Transl Med , vol.4
    • Colloca, S.1    Barnes, E.2    Folgori, A.3
  • 37
    • 78649714536 scopus 로고    scopus 로고
    • Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates
    • Capone S, Reyes-Sandoval A, Naddeo M, et al. Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates. Vaccine 2010; 29: 256-265.
    • (2010) Vaccine , vol.29 , pp. 256-265
    • Capone, S.1    Reyes-Sandoval, A.2    Naddeo, M.3
  • 38
    • 30644467602 scopus 로고    scopus 로고
    • Improved humoral immunity against tuberculosis ESAT-6 antigen by chimeric DNA prime and protein boost strategy
    • Li Z M, Song D, Zhang H Y, et al. Improved humoral immunity against tuberculosis ESAT-6 antigen by chimeric DNA prime and protein boost strategy. DNA Cell Biol 2006; 25: 25-30.
    • (2006) DNA Cell Biol , vol.25 , pp. 25-30
    • Li, Z.M.1    Song, D.2    Zhang, H.Y.3
  • 39
    • 84859040307 scopus 로고    scopus 로고
    • Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates
    • Spencer A J, Hill F, Honeycutt J D, et al. Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates. PLoS ONE 2012; 7: e33555.
    • (2012) PLoS ONE , vol.7
    • Spencer, A.J.1    Hill, F.2    Honeycutt, J.D.3
  • 40
    • 33645314357 scopus 로고    scopus 로고
    • The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs
    • Martin C, Williams A, Hernandez-Pando R, et al. The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs. Vaccine 2006; 24: 3408-3419.
    • (2006) Vaccine , vol.24 , pp. 3408-3419
    • Martin, C.1    Williams, A.2    Hernandez-Pando, R.3
  • 41
    • 33846010733 scopus 로고    scopus 로고
    • Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine
    • Derrick S C, Evering T H, Sambandamurthy V K, et al. Characterization of the protective T-cell response generated in CD4-deficient mice by a live attenuated Mycobacterium tuberculosis vaccine. Immunology 2007; 120: 192-206.
    • (2007) Immunology , vol.120 , pp. 192-206
    • Derrick, S.C.1    Evering, T.H.2    Sambandamurthy, V.K.3
  • 42
    • 80053963965 scopus 로고    scopus 로고
    • A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis
    • Sweeney K A, Dao D N, Goldberg M F, et al. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med 2011; 17: 1261-1268.
    • (2011) Nat Med , vol.17 , pp. 1261-1268
    • Sweeney, K.A.1    Dao, D.N.2    Goldberg, M.F.3
  • 43
    • 69549083228 scopus 로고    scopus 로고
    • Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics
    • Abu-Raddad L J, Sabatelli L, Achterberg J T, et al. Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics. Proc Natl Acad Sci USA 2009; 106: 13980-13985.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13980-13985
    • Abu-Raddad, L.J.1    Sabatelli, L.2    Achterberg, J.T.3
  • 44
    • 84859514168 scopus 로고    scopus 로고
    • A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults
    • Scriba T J, Tameris M, Smit E, et al. A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults. Am J Respir Crit Care Med 2012; 185: 769-778.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 769-778
    • Scriba, T.J.1    Tameris, M.2    Smit, E.3
  • 45
    • 33845917536 scopus 로고    scopus 로고
    • Vaccine strategies against latent tuberculosis infection
    • Andersen P. Vaccine strategies against latent tuberculosis infection. Trends Microbiol 2007; 15: 7-13.
    • (2007) Trends Microbiol , vol.15 , pp. 7-13
    • Andersen, P.1
  • 46
    • 34247152126 scopus 로고    scopus 로고
    • Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
    • Gagneux S, Small P M. Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development. Lancet Infect Dis 2007; 7: 328-337.
    • (2007) Lancet Infect Dis , vol.7 , pp. 328-337
    • Gagneux, S.1    Small, P.M.2
  • 48
    • 64049113596 scopus 로고    scopus 로고
    • How B-cells shape the immune response against Mycobacterium tuberculosis
    • Maglione P J, Chan J. How B-cells shape the immune response against Mycobacterium tuberculosis. Eur J Immunol 2009; 39: 676-686.
    • (2009) Eur J Immunol , vol.39 , pp. 676-686
    • Maglione, P.J.1    Chan, J.2
  • 49
    • 0037111049 scopus 로고    scopus 로고
    • Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity
    • Hoft D F, Worku S, Kampmann B, et al. Investigation of the relationships between immune-mediated inhibition of mycobacterial growth and other potential surrogate markers of protective Mycobacterium tuberculosis immunity. J Infect Dis 2002; 186: 1448-1457.
    • (2002) J Infect Dis , vol.186 , pp. 1448-1457
    • Hoft, D.F.1    Worku, S.2    Kampmann, B.3
  • 50
    • 84858711974 scopus 로고    scopus 로고
    • Tuberculosis vaccines: A strategic blueprint for the next decade
    • Edinb
    • Brennan M J, Thole J. Tuberculosis vaccines: a strategic blueprint for the next decade. Tuberculosis (Edinb) 2012; 92 (Suppl 1): S6-S13.
    • (2012) Tuberculosis , vol.92 , Issue.SUPPL. 1
    • Brennan, M.J.1    Thole, J.2
  • 51
    • 84858740658 scopus 로고    scopus 로고
    • The blueprint for vaccine research and development: Walking the path for better TB vaccines
    • Edinb
    • Lienhardt C, Fruth U, Greco M. The blueprint for vaccine research and development: walking the path for better TB vaccines. Tuberculosis (Edinb) 2012; 92 (Suppl 1): S33-S35.
    • (2012) Tuberculosis , vol.92 , Issue.SUPPL. 1
    • Lienhardt, C.1    Fruth, U.2    Greco, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.