Ten challenges for TB biomarkers

Tuberculosis

Volumn 92, Issue SUPPL.1, 2012, Pages

  Ottenhoff, Tom H M ^a   Ellner, Jerrold J ^b   Kaufmann, Stefan H E ^c  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b BOSTON UNIVERSITY   (United States)

^c MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

Biomarkers; Correlates; Tuberculosis; Vaccination

Indexed keywords

BCG VACCINE; BIOLOGICAL MARKER; LIVE VACCINE; RIFAMPICIN; SUBUNIT VACCINE;

BCG VACCINATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DISEASE COURSE; DRUG EFFICACY; DRUG RESEARCH; EXTRAPULMONARY TUBERCULOSIS; GENE EXPRESSION; HELMINTHIASIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; LATENT TUBERCULOSIS; LUNG TUBERCULOSIS; MIXED INFECTION; MYCOBACTERIUM BOVIS; NONHUMAN; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; SUICIDE GENE; TUBERCULOSIS;

EID: 84858737486     PISSN: 14729792     EISSN: 1873281X     Source Type: Journal    
DOI: 10.1016/S1472-9792(12)70007-0     Document Type: Article

References (11)

1. Biomarkers Definitions Working Group Biomarkers and surrogate end-points: preferred definitions and conceptual framework Clin Pharmacol Ther 69 3 2001 89 95
2. G Walzl, K Ronacher, W Hanekom, TJ Scriba, A Zumla Immunological biomarkers of tuberculosis Nat Rev Immunol 11 5 2011 343 354
3. TH Ottenhoff Overcoming the global crisis: "yes, we can", but also for TB...? Eur J Immunol 39 8 2009 2014 2020
4. SH Kaufmann Future vaccination strategies against tuberculosis: thinking outside the box Immunity 33 4 2010 567 577
5. SK Parida, SH Kaufmann The quest for biomarkers in tuberculosis Drug Discov Today 15 3-4 2010 148 157
6. RS Wallis, M Pai, D Menzies et al. Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice Lancet 375 9729 2010 1920 1937
7. ST Reece, SH Kaufmann Floating between the poles of pathology and protection: Can we pin down the granuloma in tuberculosis? Curr Opin Microbiol 2011; Nov 8 [Epub ahead of print]
8. MP Berry, CM Graham, FW McNab et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis Nature 466 7309 2010 973 977
9. LL Koth, OD Solberg, JC Peng, NR Bhakta, CP Nguyen, PG Woodruff Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis Am J Respir Crit Care Med 184 10 2011 1153 1163
10. S Gagneux, PM Small Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development Lancet Infect Dis 7 5 2007 328 337 (Pubitemid 46590063)
11. R van Crevel, I Parwati, E Sahiratmadja et al. Infection with Mycobacterium tuberculosis Beijing genotype strains is associated with polymorphisms in SLC11A1/NRAMP1 in Indonesian patients with tuberculosis J Infect Dis 200 11 2009 1671 1674