Protection and polyfunctional T cells induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis is highly dependent on the antigen dose

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Aagaard, Claus ^a   Hoang, Truc Thi Kim Thanh ^a   Izzo, Angelo ^b   Billeskov, Rolf ^a   Troudt, JoLynn ^b   Arnett, Kim ^b   Keyser, Andrew ^b   Elvang, Tara ^a   Andersen, Peter ^a   Dietrich, Jes ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; MODIFIED VACCINIA ANKARA EXPRESSING ANTIGEN 85B PROTEIN TB10.4 VACCINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VACCINE; ACYLTRANSFERASE; ANTIGEN 85B, MYCOBACTERIUM TUBERCULOSIS; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BCG VACCINE; IC31 ADJUVANT; OLIGODEOXYRIBONUCLEOTIDE; OLIGOPEPTIDE; TB10.4 ANTIGEN, MYCOBACTERIUM TUBERCULOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BCG VACCINATION; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HUMAN; IMMUNOGENICITY; LYMPHOCYTE FUNCTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; T LYMPHOCYTE; TUBERCULOSIS; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CD4+ T LYMPHOCYTE; CHEMISTRY; CYTOLOGY; DRUG COMBINATION; GUINEA PIG; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; TH1 CELL;

ANIMALIA; CAVIA; MYCOBACTERIUM TUBERCULOSIS;

ACYLTRANSFERASES; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; DRUG COMBINATIONS; FEMALE; GUINEA PIGS; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES; T-LYMPHOCYTES; TH1 CELLS; TUBERCULOSIS; TUBERCULOSIS VACCINES;

EID: 67649961505     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005930     Document Type: Article

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