Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates

Journal of the American Chemical Society

Volumn 133, Issue 22, 2011, Pages 8404-8407

  Gagnon, Keith T ^a   Watts, Jonathan K ^a   Pendergraff, Hannah M ^a   Montaillier, Christophe ^b   Thai, Danielle ^b   Potier, Pierre ^b   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Parc Scientifique de Luminy   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE; CELL UPTAKE; CELL-PERMEABLE; CHEMICAL STRATEGY; GENE SILENCING; HUNTINGTIN; LOCKED NUCLEIC ACID; MUTANT HUNTINGTIN; NANOMOLAR CONCENTRATION; NEGATIVE CHARGE; PROGESTERONE RECEPTOR; TARGET RECOGNITION;

ANTIGENS; GENETIC ENGINEERING; NUCLEIC ACIDS; OLIGONUCLEOTIDES;

GENE EXPRESSION;

DNA; HUNTINGTIN; MESSENGER RNA; NUCLEIC ACID; OLIGONUCLEOTIDE; OLIGOSPERMINE; PROGESTERONE RECEPTOR; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CAG REPEAT; CELL MEMBRANE PERMEABILITY; CONCENTRATION (PARAMETERS); CONJUGATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MUTANT; PROTEIN EXPRESSION;

BASE SEQUENCE; CATIONS; CELL MEMBRANE PERMEABILITY; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; SPERMINE;

EID: 79957994004     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja200312y     Document Type: Article

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