Al2O3 Nanoparticles Induce Mitochondria-Mediated Cell Death and Upregulate the Expression of Signaling Genes in Human Mesenchymal Stem Cells

Journal of Biochemical and Molecular Toxicology

Volumn 26, Issue 11, 2012, Pages 469-476

  Alshatwi, Ali A ^a   Vaiyapuri Subbarayan, Periasamy ^a   Ramesh, E ^a   Al Hazzani, Amal A ^b   Alsaif, Mohammed A ^c   Alwarthan, Abdulrahman A ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Al2O3 Nanoparticles; Cell Death; Intrinsic Pathway; Mesenchymal Stem Cells

Indexed keywords

ALUMINUM OXIDE; NANOPARTICLE; PROTEIN BCL 2;

ARTICLE; CELL DEATH; CELL NUCLEUS; CELL STRUCTURE; CELL TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; FOOD; FRAGMENTATION REACTION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; MITOCHONDRION; REAL TIME POLYMERASE CHAIN REACTION;

ALUMINUM OXIDE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; FOOD TECHNOLOGY; HUMANS; MESENCHYMAL STROMAL CELLS; METAL NANOPARTICLES; MITOCHONDRIA; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; SIGNAL TRANSDUCTION; TECHNOLOGY, PHARMACEUTICAL; TOXICITY TESTS, ACUTE; UP-REGULATION;

EID: 84870300682     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21448     Document Type: Article

References (32)

1. Frisardi V, Solfrizzi V, Capurso C, Kehoe PG, Imbimbo BP, Santamato A, Dellegrazie F, Seripa D, Pilotto A, Capurso A, Panza F. Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment. J Alzheimer Dis 2010;20:17-30.
2. Müller JP, Steinegger A, Schlatter C. Contribution of aluminum from packaging materials and cooking utensils to the daily aluminum intake. Z Lebensm Unters Forsch 1993;197:332-341.
3. Rondeau V, Jacqmin-Gadda H, Commenges D, Helmer C, Dartigues JF. Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort. Am J Epidemiol 2009;169:489-496.
4. Soni MG, White SM, Flamm WG, Burdock GA. Safety evaluation of dietary aluminum. Regul Toxicol Pharmacol 2001;33:66-79.
5. Choi SJ, Oh JM, Choy JH. Toxicological effects of inorganic nanoparticles on human lung cancer A549 cells. J Inorg Biochem 2009;103:463-471.
6. 2 and ZnO nanoparticles to human lung cells. J Nanosci Nanotechnol 2010;10:3453-3458.
7. Zhang QL, Li MQ, Ji JW, Gao FP, Bai R, Chen CY, Wang ZW, Zhang C, Niu Q. In vivo toxicity of nano-alumina on mice neurobehavioral profiles and the potential mechanisms. Int J Immunopathol Pharmacol 2011;24:23S-29S.
8. Hale AJ, Smith CA, Sutherland LC, Stoneman VE, Longthorne V, Culhane AC, Williams GT. Apoptosis: molecular regulation of cell death. Eur J Biochem 1996;237:884.
9. Williams GT, Smith CA. Molecular regulation of apoptosis: genetic controls on cell death. Cell 1993;74:777-779.
10. Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 2001;11:372-377.
11. Kim R. Unknotting the roles of Bcl-2 and Bcl-xL in cell death. Biochem Biophys Res Commun 2005;333:336-343.
12. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007;35:495-516.
13. Haupt S, Berger M, Goldberg Z, Haupt Y. Apoptosis-the p53 network. J Cell Sci 2003;116:4077-4085.
14. Hatton A, Nevelos JE, Matthews JB, Fisher J, Ingham E. Effects of clinically relevant alumina ceramic wear particles on TNF-α production by human peripheral blood mononuclear phagocytes. Biomaterials 2003;24:1193-1204.
15. Rodrigo A, Vallés G, Saldaña L, Rodríguez M, Martínez ME, Munuera L, Vilaboa N. Alumina particles influence the interactions of cocultured osteoblasts and macrophages. J Orthop Res 2006;24:46-54.
16. Bylski D, Wedemeyer C, Xu J, Sterner T, Löer F, von Knoch M. Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-α-, and OPG-mRNA in the THP-1 human monocytic cell line. J Biomed Mater Res A. 2009;89:707-716.
17. Chew SY, Park TG. Nanofibers in regenerative medicine and drug delivery. Adv Drug Deliv Rev 2009;61:987.
18. Lutolf MP, Blau HM. Artificial stem cell niches. Adv Mater 2009;21:3255-3268.
19. Phillips BW, Hentze H, Rust WL, Chen QP, Chipperfield H, Tan EK, Abraham S, Sadasivam A, Soong PL, Wang ST, Lim R, Sun W, Colman A, Dunn NR. Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage. Stem Cells Dev 2007;16:561-578.
20. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
21. Blagosklonny M, El-Diery WS. In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug. Int J Cancer 1996;67:386-392.
22. Yuan JS, Reed A, Chen F, Stewart CN Jr. Statistical analysis of real-time PCR data. BMC Bioinformatics. 2006;7:85.
23. Rittner MN. Market analysis of nanostructured materials. Am Ceram Soc Bull 2002;81:33-36.
24. Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Oberdorster E. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 2006;3:1-35.
25. Abbott LC, Maynard AD. Exposure assessment approaches for engineered nanomaterials. Risk Anal 2010;30:1634-1644.
26. Maynard AD. Nanotechnology: the next big thing, or much ado about nothing? Ann Occup Hyg 2007;51:1-12.
27. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005;113:823-839.
28. Thomas K, Sayre P. Research strategies for safety evaluation of nanomaterials. Part I. Evaluating the human health implications of exposure to nanoscale materials. Toxicol Sci 2005;87:316-321.
29. Radziun E, Dudkiewicz Wilczyńska J, Ksiazek I, Nowak K, Anuszewska EL, Kunickim A, Olszyna A, Zabkowski T. Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells. Toxicol In Vitro 2011;25:1694-1700.
30. Donner AJ, Hoover JM, Szostek SA, Espinosa JM. Stimulus-specific transcriptional regulation within the p53 network. Cell Cycle 2007;21:2594-2598.
31. Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi, J. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol 2010;30:343-352.
32. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 2005;19:975-983.