L-deprenyl reverses age-associated decline in splenic norepinephrine, interleukin-2 and interferon-γ production in old female F344 rats

NeuroImmunoModulation

Volumn 20, Issue 2, 2013, Pages 72-78

  Thyagarajan, Srinivasan ^a   Madden, Kelley S ^b   Boehm, Gary W ^c   Stevens, Suzanne Y ^b   Felten, David L ^d   Bellinger, Denise L ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c TEXAS CHRISTIAN UNIVERSITY   (United States)

^d OAKLAND UNIVERSITY WILLIAM BEAUMONT SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; d (+) Deprenyl; Immunosenescence; Sympathetic activity; T lymphocytes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; NORADRENALIN; SELEGILINE;

ADRENERGIC SYSTEM; AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENANTIOMER; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN; SPLEEN CELL; STEREOCHEMISTRY; SYMPATHETIC TONE; T LYMPHOCYTE;

AGING; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNITY, CELLULAR; INTERFERON-GAMMA; INTERLEUKIN-2; NEUROPROTECTIVE AGENTS; NOREPINEPHRINE; RATS; RATS, INBRED F344; SELEGILINE; SPLEEN; SYMPATHETIC NERVOUS SYSTEM;

EID: 84870294158     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000345043     Document Type: Article

References (29)

1. ThyagaRajan S, Priyanka HP, Pundir UP: Aging alters sympathetic noradrenergic innervation and immune reactivity in the lymphoid organs: strategies to reverse neuro-immune senescence. BrainImmune 2012 (http://www.brainimmune.com/index. phpoption=com-content&view=article& id=1598:aging-alters-sympathetic-noradrenergic-innervation-and-immune- reactivity-in-the-lymphoid-organs-strategies-toreverse-neuro-immune-senescence- &catid=73:neuro-immune-dysfunction-incommon-human-diseases&Itemid=417).
2. ThyagaRajan S, Felten DL: Modulation of neuroendocrine-immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech Ageing Dev 2002; 123: 1065-1079.
3. Bellinger DL, Millar BA, Perez S, Carter J, Wood C, ThyagaRajan S, Molinaro C, Lubahn C, Lorton D: Sympathetic modulation of immunity: relevance to disease. Cell Immunol 2008; 252: 27-56.
4. Felten SY, Bellinger DL, Collier TJ, Coleman PD, Felten DL: Decreased sympathetic innervation of spleen in aged Fischer 344 rats. Neurobiol Aging 1987; 8: 159-165.
5. Bellinger DL, Ackerman KD, Felten SY, Felten DL: A longitudinal study of age-related loss of noradrenergic nerves and lymphoid cells in the rat spleen. Exp Neurol 1992; 116: 295-311.
6. Anderson RM, Weindruch RL: The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol 2012; 24: 101-106.
7. Willis LM, Shukitt-Hale B, Joseph JA: Modulation of cognition and behavior in aged animals: role for antioxidant-and essential fatty acid-rich plant foods. Am J Clin Nutr 2009; 89: 1602S-1606S.
8. Molano A, Meydani SN: Vitamin E, signalosomes and gene expression in T cells. Mol Aspects Med 2012; 33: 55-62.
9. Holland AM, van den Brink MR: Rejuvenation of the aging T cell compartment. Curr Opin Immunol 2009; 21: 454-459.
10. ThyagaRajan S, Felten SY, Felten DL: Restoration of sympathetic noradrenergic nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized and old Fischer 344 rats. J Neuroimmunol 1998; 81: 144-157.
11. ThyagaRajan S, Madden KS, Kalvass JC, Dimitrova SS, Felten SY, Felten DL: L-Deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of noradrenergic nerve fibers in the spleens of old F344 rats. J Neuroimmunol 1998; 92: 9-21.
12. ThyagaRajan S, Madden KS, Stevens SY, Felten DL: Anti-tumor effect of L-deprenyl is associated with enhanced central and peripheral neurotransmission and immune reactivity in rats with carcinogen-induced mammary tumors. J Neuroimmunol 2000; 109: 95-104.
13. ThyagaRajan S, Madden KS, Stevens SY, Felten DL: Restoration of splenic noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-deprenyl and L-desmethyldeprenyl. Int J Immunopharmacol 2000; 22: 523-536.
14. Caslake R, Macleod A, Ives N, Stowe R, Counsell C: Monoamine oxidase B inhibitors versus other dopaminergic agents in early Parkinson's disease. Cochrane Database Syst Rev 2009; 4:CD006661.
15. Ebadi M, Brown-Borg H, Ren J, Sharma S, Shavali S, El ReFaey H, Carlson EC: Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases. Curr Drug Targets 2006; 7: 1513-1529.
16. Magyar K, Szende B, Jenei V, Tábi T, Pálfi M, Szöko E: R-Deprenyl: pharmacological spectrum of its activity. Neurochem Res 2010; 35: 1922-1932.
17. ThyagaRajan S, Madden KS, Teruya B, Stevens SY, Felten DL, Bellinger DL: Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary lymphoid organs in female Fischer 344 rats. J Neuroimmunol 2011; 233: 54-64.
18. Davila DR, Kelley KW: Sex differences in lectin-induced interleukin-2 synthesis in aging rats. Mech Ageing Dev 1988; 44: 231-240.
19. Simioni PU, Costa EH, Tamashiro WM: Aging reduces the primary humoral response and the in vitro cytokine production in mice. Braz J Med Biol Res 2007; 40: 1111-1120.
20. Maue AC, Haynes L: CD4+ T cells and immunosenescence-a mini-review. Gerontology 2009; 55: 491-495.
21. Müller T, Kuhn W, Krüger R, Przuntek H: Selegiline as immunostimulant-a novel mechanism of action? J Neural Transm Suppl 1998; 52: 321-328.
22. Madden KS, Moynihan JA, Brenner GJ, Felten SY, Felten DL, Livnat S: Sympathetic nervous system modulation of the immune system. III. Alterations in T and B cell proliferation and differentiation in vitro following chemical sympathectomy. J Neuroimmunol 1994; 49: 77-87.
23. Garcia GG, Miller RA: Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res Rev 2011; 10: 26-34.
24. Weng NP, Akbar AN, Goronzy J: CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol 2009; 30: 306-312.
25. Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy GO, Carrillo MC: Why (-)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects. Mech Ageing Dev 2002; 123: 1087-1100.
26. Semkova I, Wolz P, Schilling M, Krieglstein J: Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage. Eur J Pharmacol 1996; 315: 19-30.
27. Yasar S, Gaál J, Panlilio LV, Justinova Z, Molnár SV, Redhi GH, Schindler CW: A comparison of drug-seeking behavior maintained by D-amphetamine, L-deprenyl (selegiline), and D-deprenyl under a second-order schedule in squirrel monkeys. Psychopharmacology (Berl) 2006; 183: 413-421.
28. Freire-Garabal M, Balboa JL, Núñez MJ, Castaño MT, Llovo JB, Fernández-Rial JC, Belmonte A: Effects of amphetamine on Tcell immune response in mice. Life Sci 1991; 49:PL107-PL112.
29. Yu Q, Zhang D, Walston M, Zhang J, Liu Y, Watson RR: Chronic methamphetamine exposure alters immune function in normal and retrovirus-infected mice. Int Immunopharmacol 2002; 2: 951-962.