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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7672-7676

Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists

(16) Aguilar, Nuria a Mir, Marta a Grima, Pedro M b López, Manel a Segarra, Victor a Esteban, Laia c Moreno, Imma a Godessart, Nuria a Tarrasón, Gema a Domenech, Teresa a Vilella, Dolors a Armengol, Clara a Córdoba, Mònica a Sabaté, Mar a Casals, Daniel a Domínguez, Maria a

a Laboratorios Almirall SA ^* (Spain)

b Ferrer Grupo (Spain)

c Dukechem (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; AMPHOLYTE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER CELL; LYMPHOCYTOPENIA; MICROSOME; MOLECULAR DOCKING; NONHUMAN; RAT; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; LYMPHOPENIA; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; RECEPTORS, LYSOSPHINGOLIPID; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

RATTUS;

EID: 84870254686 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.09.110 Document Type: Article

Times cited : (4)

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