A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists

Journal of Medicinal Chemistry

Volumn 47, Issue 27, 2004, Pages 6662-6665

  Hale, Jeffrey J ^a   Lynch, Christopher L ^b   Neway, William ^a   Mills, Sander G ^a   Hajdu, Richard ^a   Keohane, Carol Ann ^a   Rosenbach, Mark J ^a   Milligan, James A ^a   Shei, Gan Ju ^a   Parent, Stephen A ^a   Chrebet, Gary ^a   Bergstrom, James ^a   Card, Deborah ^a   Ferrer, Marc ^a   Hodder, Peter ^a   Strulovici, Berta ^a   Rosen, Hugh ^c   Mandala, Suzanne ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ABBOTT LABORATORIES   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 CARBOXYAZETIDINE; FINGOLIMOD; IMMUNOMODULATING AGENT; RECEPTOR SUBTYPE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE 1 RECEPTOR AGONIST; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; AZETIDINES; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; DOGS; DRUG DESIGN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTES; MACACA MULATTA; MICE; RATS; RATS, INBRED LEW; RECEPTORS, LYSOSPHINGOLIPID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 19944429032     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0492507     Document Type: Article

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