Discovery of thiadiazole amides as potent, S1P 3-sparing agonists of sphingosine-1-phosphate 1 (S1P 1) receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2456-2459

  Xu, Heng ^a   Zhang, Haibo ^a   Luan, Linbo ^a   Xu, Yan ^a   Li, Chengyong ^a   Wang, Yonghui ^a   Han, Fangbin ^a   Yang, Ting ^a   Ren, Feng ^a   Xiang, Jia Ning ^a   Elliott, John D ^a   Zhao, Yonggang ^a   Guo, Taylor B ^a   Lu, Hongtao ^a   Zhang, Wei ^a   Hirst, David ^a   Lindon, Matthew ^a   Lin, Xichen ^a  

^a GLAXOSMITHKLINE   (China)

Author keywords

Multiple sclerosis (MS); S1P 1 receptor agonists; SAR; Thiadiazole amides

Indexed keywords

AMIDE; FINGOLIMOD; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THIADIAZOLE DERIVATIVE;

ANIMAL MODEL; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; IMMUNOLOGIC FACTORS; LYMPHOCYTES; MICE; RECEPTORS, LYSOSPHINGOLIPID; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 84862794635     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.016     Document Type: Article

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