Acute cardioembolic cerebral infarction: Answers to clinical questions

Current Cardiology Reviews

Volumn 8, Issue 1, 2012, Pages 54-67

  Arboix, Adrià ^a,b   Alió, Josefina ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Atrial fibrillation; Cardiac source of emboli; Cardioembolic stroke; Heart failure; Oral anticoagulation; Outcome; Recurrent embolization

Indexed keywords

ACETYLSALICYLIC ACID; DABIGATRAN; WARFARIN;

ACUTE CARDIOEMBOLIC CEREBRAL INFARCTION; ANTICOAGULANT THERAPY; AORTA ATHEROSCLEROSIS; BRAIN ELECTROPHYSIOLOGY; BRAIN INFARCTION; CARDIOEMBOLIC STROKE; CORTICAL SENSORY APHASIA; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HUMAN; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATENT FORAMEN OVALE; PRIORITY JOURNAL; REVIEW; TRANSCRANIAL DOPPLER; TRANSESOPHAGEAL ECHOCARDIOGRAPHY; TRANSTHORACIC ECHOCARDIOGRAPHY; VALSALVA MANEUVER;

ANTICOAGULANTS; ATRIAL FIBRILLATION; CEREBRAL INFARCTION; HEART DISEASES; HUMANS; INTRACRANIAL EMBOLISM;

EID: 84870223674     PISSN: 1573403X     EISSN: 18756557     Source Type: Journal    
DOI: 10.2174/157340312801215791     Document Type: Review

References (123)

1. Arboix A, Alió J. Cardioembolic stroke: clinical features, specific cardiac disorders and prognosis. Current Cardiol Rev 2010; 6: 150-61.
2. Weir NU. An update on cardioembolic stroke. Postgrad Med J 2008; 84: 133-42.
3. Ferro JM. Brain embolism. Answers to practical questions. J Neurol 2003; 250: 139-47.
4. Murtagh B, Smalling RW. Cardioembolic stroke. Curr Atherosclr Rep 2006; 8: 310-6.
5. Ferro JM. Cardioembolic stroke: an update. Lancet Neurol 2003; 2: 177-88.
6. Di Tullio MR, Homma S. Mechanisms of cardioembolic stroke. Curr Cardiol Rep 2002; 4: 141-8.
7. MacDougall NJJ, Amarasinghe S, Muir KW. Secondary prevention of stroke. Expert Rev Neurother 2009; 7: 1103-5.
8. Khoo CW, Lip GYH. Clinical outcomes of acute stroke patients with atrial fibrillation. Expert Rev Neurother 2009; 7: 371-4.
9. Chamorro A, Vila N, Saiz A, Alday M, Tolosa E. Early anticoagulation after large cerebral embolic infarction: a safety study. Neurology 1995; 45: 861-5.
10. Cerebral Embolism Study Group. Immediate anticoagulation of embolic stroke: brain hemorrhage and management opinions. Stroke 1984; 15: 779-89.
11. Cerebral Embolism Study Group. Immediate anticoagulation of embolic stroke: a randomized trial. Stroke 1983; 14: 668-76.
12. Cerebral Embolism Task Force. Cardiogenic brain embolism. Arch Neurol 1986; 43: 71-84.
13. Cerebral Embolism Task Force. Cardiogenic brain embolism. The second report of the Cerebral Embolism Task Force. Arch Neurol 1989; 46: 727-43.
14. Arboix A, Vericat MC, Pujades R, Massons J, García-Eroles L, Oliveres M. Cardioembolic infarction in The Sagrat Cor-Alianza Hospital of Barcelona Stroke Registry. Acta Neurol Scand 1997; 96: 407-12.
15. Bogousslavsky J, Van Melle G, Regli F. The Lausanne Registry: analysis of 1.000 consecutive patients with first stroke. Stroke 1988; 19: 1083-92.
16. Timsit SG, Sacco RL, Mohr JP, et al. Brain infarction severity differs according to cardiac or arterial embolic source. Neurology 1993; 43: 728-33.
17. Vázquez J, Gendre J, Martí-Vilalta JL. Manifestaciones clínicas del infarto cerebral embólico de origen cardíaco. In: Isquemia cerebral. Matías-Guiu J, Martínez-Vila E, Martí-Vilalta JL (eds). Barcelona, MCR SA, 1990; pp 185-202.
18. Al-Rajeh S, Larbi E, Bademosi O, et al. Stroke in a tertiary hospital in Saudi Arabia: a study of 372 cases. Eur Neurol 1991; 31: 251-256.
19. Rothrock JF, Lyden PD, Brody ML, et al. An analysis of ischemic stroke in an urban southern california population. The University of California, San Diego, Stroke Data Bank. Arch Intern Med 1993; 153: 619-24.
20. Norrving B, Löwenhielm P. Epidemiology of first stroke in Lund- Orup, Sweden, 1983-1985. Incidence of first stroke and aged-related changes in subtypes. Acta Neurol Scand 1988; 78: 408-13.
21. Arboix A, Cendrós V, Besa M, et al. Trends in risk factors, stroke subtypes and outcome. Nineteen-year data from the Sagrat Cor Hospital of Barcelona Stroke Registry. Cerebrovasc Dis 2008;26:509-16.
22. Arboix A, Alió J. Acute cardioembolic stroke: an update. Expert Rev Cardiovasc Ther 2011; 9: 367-9.
23. Ustrell X, Pellisé A. Cardiac workup of ischemic stroke. Current Cardiol Rev 2010; 6: 175-183.
24. Gaillard N, Deltour S, Vilotijevic B, et al. Detection of paroxysmal atrial fibrillation with transtelephonic EKG in TIA or stroke patients. Neurology 2010; 74: 1666-70.
25. Morris JG, Duffis EJ, Fisher M. Cardiac workup of ischemic stroke. Can we improve our diagnostic yield? Stroke 2009; 40: 2893-8.
26. Serena J, Jiménez-Nieto M, Silva Y, Castellanos M. Patent foramen ovale in cerebral infarction. Current Cardiol Rev 2010; 6: 162-74.
27. Caplan LR. Brain embolism, revisited. Neurology 1993; 43: 1281-7.
28. Bogousslavsky J, Cachin C, Regli F, Despland PA, Van Melle G, Kappenberger L. Cardiac sources of embolism and cerebral infarction- clinical consequences and vascular concomitants: The Lausanne Stroke Registry. Neurology 1991; 41: 855-9.
29. Timsit SG, Sacco MS, Mohr JP, et al. Early clinical differentation of cerebral infarction from severe atherosclerotic stenosis and cardioembolism. Stroke 1992; 23: 486-91.
30. Mohr JP, Gautier JC, Hier DB. Middle cerebral artery disease. In: Barnett HJM, Stein BM, Mohr JP, Yatsu FM (eds): Stroke: Pathophysiology, diagnosis and management. New York. Churchill Livingstone, 1992, pp 361-417.
31. Minematsu K, Yamaguchi T, Omae T. Spectacular shrinking deficit: rapid recovery from a major hemispheric syndrome by migration of an embolus. Neurology 1992; 42: 157-62.
32. Arboix A, Bechich S. Recurrencia precoz de la regresión espectacular del déficit hemisférico neurológico como forma de presentación de un infarto cardioembólico. Rev Neurol 1998; 27: 601-3.
33. Bechich J, Arboix A. Regresión espectacular del déficit hemisférico neurológico. Neurología 1997; 12: 45-6.
34. Martin R, Bogousslavsky J. Embolic versus nonembolic causes of ischemic stroke. Cerebrovasc Dis 1995; 5: 70-4.
35. Hart RG. Cardiogenic embolism to the brain. Lancet 1992; 339: 589-94.
36. Caplan LR. Clinical diagnosis of brain embolism. Cerebrovasc Dis 1995; 5: 79-88.
37. Arboix A, Arbe G, García-Eroles L, Oliveres M, Parra O, Massons J. Infarctions in the vascular territory of the posterior cerebral artery: clinical features in 232 patients. BMC Res Notes 2011; 4: 329, doi: 10.1186/1756-0500-4-329.
38. Arboix A, Martí-Vilalta JL. Lacunar stroke. Expert Rev Neurother 2009; 9: 179-96.
39. Cacciatore A, Russo LS Jr. Lacunar infarction as an embolic complication of cardiac and arch angiography. Stroke 1991; 22: 1603-5.
40. Lodder J, Bamford JM, Sandercock PAG, Jones LN, Warlow CP. Are hypertension or cardiac embolism likely causes of lacunar infarction? Stroke 1990; 21: 375-81.
41. Fieschi C, Sette G, Fiorelli M, et al. Clinical presentation and frequency of potential sources of embolism in acute ischemic stroke patients: the experience of the Rome Acute Stroke Registry. Cerebrovasc Dis 1995; 5: 75-8.
42. Bogousslavsky J, Regli J, Uské A, Maeder Ph. Early spontaneous hematoma in cerebral infarct: is primary cerebral hemorrhage overdiagnosed? Neurology 1991; 41: 837-40.
43. Cuadrado-Godia E, Ois A, Roquer J. Heart failure in acute ischemic stroke. Current Cardiol Rev 2010; 6: 202-13.
44. Font MA, Krupinski J, Arboix A. Antithrombotic medication for cardioembolic stroke prevention. Stroke Res Treat 2011; 607852. doi: 10.4061/2011/607852
45. Arboix A, García-Eroles L, Massons J, Oliveres M, Targa C. Hemorrhagic lacunar stroke. Cerebrovasc Dis 2000; 10: 229-234.
46. Pujadas R, Arboix A, Anguera N, Rafel J, Sagués F, Casañas R. Mitral annular calcification as a marker of complex aortic atheroma in patients with stroke of uncertain etiology. Echocardiography 2008; 25: 124-31.
47. Kent DM, Trikalinos TA, Thaler DE. Patent foramen ovale and cryptogenic stroke. N Engl J Med 2008; 358: 1519-20.
48. Overell JR, Bone I, Lees KR. Interatrial septal abnormalities and stroke: a meta-analysis of case-control studies. Neurology 2000; 55: 1172-9.
49. Serena J, Marti-Fàbregas J, Santamarina E, et al. Recurrent stroke and massive right-to-left shunt: results from the prospective Spanish multicenter (CODICIA) study. Stroke 2008; 39: 3131-6.
50. Sacco RL, Adams R, Albers G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: cosponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 2006; 37: 577-617.
51. Messé SR, Silverman IE, Kizer JR, et al. Practice parameter: recurrent stroke with patent foramen ovale and atrial septal aneurysm: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2004; 62: 1042-50.
52. The European Stroke Organization (ESO) Executive Committee and the ESO Writing Committee. ESO Guidelines for management of ischaemic stroke 2008. Cerebrovasc. Dis 2008; 25: 457-507.
53. Amarenco P, Duyckaerts C, Tzourio C, Henin D, Bousser MG, Hauw JJ. The prevalence of ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med 1992; 326: 21-5.
54. Meissner I, Khandheria BK, Sheps SG, et al. Atherosclerosis of the aorta: Risk factor, risk marker, or innocent bystander? A prospective population-based transesophageal echocardiographic study. J Am Coll Cardiol 2004; 44: 1018-24.
55. Pujadas R, Arboix A, Anguera N, Oliveres M, Massons J, Comes E. Papel de las placas complejas de ateroma aórtico en la recurrencia del infarto cerebral de etiología incierta. Rev Esp Cardiol 2005; 58: 34-40.
56. Capmany RP, Ibañez MO, Pesquer XJ. Complex atheromatosis of the aortic arch in cerebral infarction. Current Cardiol Rev 2010; 6: 184-93.
57. Tunick PA, Nayar AC, Goodkin GM, et al. Effect of treatment on the incidence of stroke and other emboli in 519 patients with severe thoracic aortic plaque. Am J Cardiol 2002; 90: 1333-5.
58. Benjamin EJ, Plehn JF, D'Agostino RB, et al. Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med 1992; 327: 374-9.
59. Pujadas RC, Arboix A, Casañas-Muñoz R, Anguera-Ferrando N. Specific cardiac disorders in 402 consecutive patients with ischaemic cardioembolic stroke. Int J Cardiol 2004; 95: 129-34.
60. Caplan LR, Hier DB, D'Cruz I. Cerebral embolism in the Michael Reese Stroke Registry. Stroke 1983; 14: 530-6.
61. Hornig CR, Brainin M, Mast H. Cardioembolic stroke: results from three current stroke data banks. Neuroepidemiology 1994; 13: 318-23.
62. Lodder J, Krijne-Kubat B, Broekman J. Cerebral hemorrhagic infarction at autopsy: cardiac embolic cause and the relationship to the cause of death. Stroke 1986; 17: 626-9.
63. Arboix A, García-Eroles L, Massons J, Oliveres M. Predictive clinical factors of in-hospital mortality in 231 consecutive patients with cardioembolic cerebral infarction. Cerebrovasc Dis 1998; 8: 8-13.
64. Hart RG, Coull BM, Hart D. Early recurrent embolism associated with nonvalvular atrial fibrillation: a retrospective study. Stroke 1983; 14: 688-93.
65. Broderick JP, Phillips SJ, O'Fallon M, Whisnant JP. Heart diseases as a potential cause of stroke. (Abstract). Stroke 1990; 21: 173.
66. Arboix A, Massons J, Garcia-Eroles L, Comes E, Balcells M, Oliveres M. Recurrent ischemic stroke: study of 605 patients. Med Clin (Barc) 2011; 137: 541-5.
67. Sacco RL, Foulkes MA, Mohr JP, Wolf PA, Hier DB, Price TR. Determinants of early recurrence of cerebral infarction. The Stroke Data Bank. Stroke 1989; 20: 983-9.
68. Yasaka M, Yamaguchi T, Oita J, Sawada T, Shichiri M, Omae T. Clinical features of recurrent embolization in acute cardioembolic stroke. Stroke 1993; 24: 1681-5.
69. Arboix A, Vicens A, Vives JM, García-Eroles L, Massons J. Spontaneous neurological deterioration in acute cardioembolic stroke: a subgroup of patients with early severe prognosis. J Neurol Res 2011; 1: 133-8.
70. Arboix A, García Eroles L, Oliveres M, Massons JB, Targa C. Clinical predictors of early embolic recurrence in presumed cardioembolic infarction. Cerebrovasc Dis 1998; 8: 345-53.
71. Yamanouchi H, Shimada H, Tomonaga M, Matsushita S. Recurrence of embolic stroke in non-valvular atrial fibrillation (NVAF). An autopsy study. Acta Neurol Scand 1989; 80: 123-9.
72. Sacco RL, Shi T, Zamanillo MC, Kargman DE. Predictors of mortality and recurrence after hospitalized cerebral infarction in an urban community: The Northern Manhattan Stroke Study. Neurology 1994; 44: 626-34.
73. Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke registry: analysis of 1.000 consecutive patients with first stroke. Stroke 1988; 19: 1083-92.
74. Broderick JP, Phillips SJ, O'Fallon M, Frye RL, Whisnant JP. Relationship of cardiac disease to stroke occurrence, recurrence and mortality. Stroke 1992; 23: 1250-6.
75. Sandercock P, Bamford J, Dennis M, et al. Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxforsdshire community stroke project). BMJ 1992; 305: 1460-5.
76. Cabin HS, Clubb KS, Hall C, Perlmutter RA, Feinstein AR. Risk for systemic embolization of atrial fibrillation without mitral stenosis. Am J Cardiol 1990; 65: 1112-6.
77. Lai SM, Alter M, Friday G, Sobel E. A multifactorial analysis of risk factors for recurrence of ischemic stroke. Stroke 1994; 25: 958-62.
78. Canhao P, Melo TP, Salgado AV, et al. Nausea and vomiting in acute ischemic stroke. Cerebrovasc Dis 1997; 7: 220-5.
79. Fisher CM. Vomiting out of proportion to dizziness in ischemic brainstem strokes. Neurology 1996; 46: 267.
80. Jaster JH, Porterfield LM, Bertorini TE, Dohan TC Jr, Becske T. Stroke and cardiac arrest. Neurology 1996; 47: 1357.
81. Stober T, Sen S, Anstätt Th, Bette L. Correlation of cardiac arrhythmias with brainstem compression in patients with intracerebral hemorrhage. Stroke 1988; 19: 688-92
82. Furlan AJ, Cavalier SJ, Hobbs RE, Weinstein MA, Modic MT. Hemorrhage and anticoagulation after nonseptic embolic brain infarction. Neurology 1982; 32: 280-2.
83. Easton JD. Epidemiology of stroke recurrence. Cerebrovasc Dis 1997; 7 (Suppl 1): 2-4.
84. van Latum JC, Koudstaal PJ, Venables GS, van Gijn J, Kappelle LJ, Algra A for the European Atrial Fibrillation Trial (EAFT) Study Group. Predictors of major vascular events in patients with a transient ischemic attack or minor ischemic stroke and with nonrheumatic atrial fibrillation. Stroke 1995; 26: 801-6.
85. Hillbom M, Kaste M. Does ethanol intoxication promote brain infarction in young adults? Lancet 1978; 1181-3.
86. Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG. Stroke and alcohol consumption. N Engl J Med 1986; 315: 1041-6.
87. Gill JS, Shipley MJ, Tsemenzis SA, et al. Alcohol consumption. A risk factor for hemorrhagic and non-hemorrhagic stroke. Am J Med 1991; 90: 489-97.
88. Camargo CA Jr. Moderate alcohol consumption and stroke. The epidemiologic evidence. Stroke 1989; 20: 1611-26.
89. Palomäki H, Kaste M. Regular light-to-moderate intake of alcohol and the risk of ischemic stroke. Is there a beneficial effect? Stroke 1993; 24: 1828-32.
90. Iso H, Kitamura A, Shimamoto T, et al. Alcohol intake and the risk of cardiovascular disease in middle-aged Japanese men. Stroke 1995; 26: 767-73.
91. Beghi E, Bogliun G, Cosso P, et al. Stroke and alcohol intake in a hospital population. A case-control study. Stroke 1995; 26: 1691-6.
92. Wannamethee SG, Shaper AG. Patterns of alcohol intake and risk of stroke in middle-aged British men. Stroke 1996; 27: 1033-9.
93. Gorelick PhB. The status of alcohol as a risk factor for stroke. Stroke 1989; 20: 1607-10.
94. Kaplan NM. Alcohol and hypertension. Lancet 1995; 345: 1588-9.
95. Puddey IB, Beilin LJ, Vandongen R. Regular alcohol use raises blood pressure in treated hypertensive subjects. A randomised controlled trial. Lancet 1987; 647-51.
96. Brigden W, Robinson J. Alcoholic heart disease. BMJ 1964; 2: 1283-9.
97. Anonymous. Alcohol and atrial fibrillation. Lancet 1985; 2: 1374.
98. Estruch R. Efectos cardiovasculares del alcohol. Med Clin (Barc) 1995; 105: 628-35.
99. Miralles R, Molina L. Fibrilación auricular paroxística e intoxicación alcohólica aguda. Med Clin (Barc) 1985; 85: 814.
100. Ettinger PO, Wu CF, De La Cruz C Jr, Weise AB, Ahmed SS, Regan TJ. Arrhythmias and the Holiday Heart: alcohol associated cardiac rhythm disorders. Am Heart J 1978; 95: 555-62.
101. MacMahon SW, Norton RN. Alcohol and hypertension: implications for prevention and treatment. Ann Intern Med 1986; 105: 124-6.
102. Marmot M, Brunner E. Alcohol and cardiovascular disease: the status of the U shaped curve. BMJ 1991; 303: 565-8.
103. Bonita R. Epidemiology of stroke. Lancet 1992; 339: 342-7.
104. Hansagi H, Romelsjö A, de Verdier MG, Andréasson S, Leifman A. Alcohol consumption and stroke mortality. 20-year follow-up of 15077 men and women. Stroke 1995; 26: 1768-73.
105. Official Guidelines for the diagnosis and treatment of cerebrovascular diseases (2 edition). Catalan Society of Neurology. Cel lula (ed). Barcelona 2011, pp 159-240.
106. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-51.
107. Millán M, Dorado L, Dávalos A. Fibrinolytic therapy in acute stroke. Current Cardiol Rev 2010; 6: 218-26.
108. González EB, Román AR, González-Juanatey JR. Cardioembolic stroke: call for a multidisciplinary approach. Cerebrovasc Dis 2009; 27 (Suppl 1): 82-7.
109. Arboix A, Oliveres M, Massons J, Pujades R, García-Eroles L. Early differentiation of cardioembolic from atherothrombotic cerebral infarction: a multivariate analysis. Eur J Neurol 1999; 6: 677-83.
110. Ramirez-Lassepas M, Cipolle RJ, Bjork RJ, et al. Can embolic stroke be diagnosed on the basis of neurologic clinical criteria? Arch Neurol 1987; 44: 87-9.
111. Kittner SJ, Sharkness CM, Sloan MA, et al. Infarcts with a cardiac source of embolism in the NINDS Stroke Data Bank: neurological examination. Neurology 1992; 42: 299-302.
112. Kittner SJ, Sharkness CM, Price TR, et al. Infarcts with a cardiac source of embolism in the NINSDS Stroke Data Bank: historical features. Neurology 1990; 40: 281-4.
113. Arboix A, Miguel M, Císcar E, Garcia-Eroles L, Massons J, Balcells M. Cardiovascular risk factors in patients aged 85 years or older with ischemic stroke. Clin Neurol Neurosurg 2006; 108: 638-43.
114. Arboix A, Garcia-Eroles L, Massons J, Oliveres M, Targa C. Lacunar infarcts in patients aged 85 years and older. Acta Neurol Scand 2000; 101: 25-9.
115. Bogousslavsky J, Van Melle G, Regli F, Kappenberger L. Pathogenesis of anterior circulation stroke in patients with nonvalvular atrial fibrillation: The Lausanne Stroke Registry. Neurology 1990; 40: 1046-50.
116. Arboix A, García Eroles L, Massons JB, Oliveres M, Pujades R, Targa C. Atrial fibrillation and stroke: clinical presentation of cardioembolic versus atherothrombotic infarction. Int J Cardiol 2000; 73: 33-42.
117. D'Olhaberriague L, Hernández-Vidal A, Molina L, et al. A prospective study of atrial fibrillation and stroke. Stroke 1989; 20: 1648-52.
118. Weinberger J, Rothlauf E, Materese E, Halperin J. Noninvasive evaluation of the extracranial carotid arteries in patients with cerebrovascular events and atrial fibrillations. Arch Intern Med 1988; 148: 1785-8.
119. Keller TS, McGillicuddy JE, LaBond VA, Kindt GW. Volume expansion in focal cerebral ischemia: the effect of cardiac output on local cerebral blood flow. Clin Neurosurg 1982; 29: 40-50.
120. Lavy S, Stern S, Melamed E, Cooper G, Keren A, Levy P. Effect of chronic atrial fibrillation on regional cerebral blood flow. Stroke 1980; 11: 35-8.
121. Petersen P, Kastrup J, Videbaek R, Boysen G. Cerebral blood flow before and after cardioversion of atrial fibrillation. J Cereb Blood Flow Metab 1989; 9: 422-5.
122. Friedman PJ. Atrial fibrillation after stroke in the elderly. Stroke 1991; 22: 209-214.
123. Censori B, Camerlingo M, Casto L, Ferraro B, Gazzaniga GC, Cesana B. Prognostic factors in first-ever stroke in the carotid territory seen within 6 hours after onset. Stroke 1993; 24: 532-5.