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Volumn 9, Issue 6, 2012, Pages 556-565

Anatomical, biochemical and physiological considerations of the colon in design and development of novel drug delivery systems

Author keywords

Luminal pressure; Lymphoid tissue; Polymers; Prodrugs; Serosa; Transit time

Indexed keywords

AZO REDUCTASE; BETA GLUCURONIDASE; CHOLECYSTOKININ A RECEPTOR; DEXTRANASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GASTRIN RELEASING PEPTIDE RECEPTOR; GLYCOSIDASE; NEUROKININ 2 RECEPTOR; POLYGALACTURONASE; POLYMER; POLYSACCHARIDE; PRODRUG;

EID: 84870222109     PISSN: 15672018     EISSN: 18755704     Source Type: Journal    
DOI: 10.2174/156720112803529774     Document Type: Article
Times cited : (13)

References (121)
  • 2
    • 0038725720 scopus 로고    scopus 로고
    • Pharmaceutical approaches to colon targeted drug delivery systems
    • Chourasia, M.K.; Jain, S.K. Pharmaceutical approaches to colon targeted drug delivery systems. J. Pharm. Sci., 2003, 6, 33-66.
    • (2003) J. Pharm. Sci , vol.6 , pp. 33-66
    • Chourasia, M.K.1    Jain, S.K.2
  • 3
    • 0002179096 scopus 로고
    • Colonic delivery of therapeutic peptides and proteins
    • In: Biek PR, ed., New York: Marcel Dekker
    • Mackay, M.; Tomlinson, E. Colonic delivery of therapeutic peptides and proteins, In: Biek PR, ed. Colonic drug absorption and metabolism. New York: Marcel Dekker, 1993, pp. 159-176.
    • (1993) Colonic Drug Absorption and Metabolism , pp. 159-176
    • Mackay, M.1    Tomlinson, E.2
  • 4
    • 51949115260 scopus 로고    scopus 로고
    • Perspectives on colonic drug delivery. Business Briefing
    • Abdul, B.; John, B. Perspectives on colonic drug delivery. Business Briefing. Pharm. Tech., 2003, 185-190.
    • (2003) Pharm. Tech , pp. 185-190
    • Abdul, B.1    John, B.2
  • 5
    • 0033995306 scopus 로고    scopus 로고
    • Colon specific drug delivery systems
    • Sarasija, S.; Hosta, A. Colon specific drug delivery systems. Int. J. Pharm. Sci., 2000, 62, 1-8.
    • (2000) Int. J. Pharm. Sci , vol.62 , pp. 1-8
    • Sarasija, S.1    Hosta, A.2
  • 7
    • 0018728379 scopus 로고
    • Retrograde spread of hydrocortisone containing foam given intrarectally in ulcerative colitis
    • Farthing, M.J.G.; Rutland, M.D.; Clark, M.L. Retrograde spread of hydrocortisone containing foam given intrarectally in ulcerative colitis. Br. Med. J., 1979, 2, 822-824.
    • (1979) Br. Med. J , vol.2 , pp. 822-824
    • Farthing, M.J.G.1    Rutland, M.D.2    Clark, M.L.3
  • 8
    • 0021815879 scopus 로고
    • The spreading of foam and solution enemas
    • Wood, E.; Wilson, C.G.; Hardy, J.G. The spreading of foam and solution enemas. Int. J. Pharm., 1985, 25,191-197.
    • (1985) Int. J. Pharm , vol.25 , pp. 191-197
    • Wood, E.1    Wilson, C.G.2    Hardy, J.G.3
  • 13
    • 0031563889 scopus 로고    scopus 로고
    • Physiology of the colorectal barrier
    • Christine, Edwards. Physiology of the colorectal barrier. Adv. Drug Del. Rev., 1997, 28, 173-190.
    • (1997) Adv. Drug Del. Rev , vol.28 , pp. 173-190
    • Christine, E.1
  • 14
    • 84870159393 scopus 로고    scopus 로고
    • BD chaurasia's human anatomy regional and applied dissection and clinical, lower limb, abdomen, pelvis. 4th ed.; CBS publishers and distributors: New delhi
    • BD chaurasia's human anatomy regional and applied dissection and clinical vol 2, lower limb, abdomen, pelvis. 4th ed.; CBS publishers and distributors: New delhi, 2004, pp. 252-259.
    • (2004) , vol.2 , pp. 252-259
  • 16
    • 0014657524 scopus 로고
    • Extrinsic nervous control of colonic motility and blood flow. An experimental study in the cat
    • Hulten, L. Extrinsic nervous control of colonic motility and blood flow. An experimental study in the cat. Acta Physiol. Stand., 1969, 335(Suppl), 1-10.
    • (1969) Acta Physiol. Stand , vol.335 , Issue.SUPPL. , pp. 1-10
    • Hulten, L.1
  • 17
    • 0015818745 scopus 로고
    • Colonic motility in the cat. II Extrinsic nervous control
    • Rostad, H. Colonic motility in the cat. II Extrinsic nervous control. Acta. Physiol. Scand., 1973, 89, 91-103.
    • (1973) Acta. Physiol. Scand , vol.89 , pp. 91-103
    • Rostad, H.1
  • 18
    • 0021333198 scopus 로고
    • Comparative anatomy of the myenteric plexus of the distal colon in eight mammals
    • Christensen, J.; Stiles, M.J.; Rick, G.A.; Sutherland, J. Comparative anatomy of the myenteric plexus of the distal colon in eight mammals. Gastroenterology, l984, 86, 706-713.
    • (1984) Gastroenterology , vol.86 , pp. 706-713
    • Christensen, J.1    Stiles, M.J.2    Rick, G.A.3    Sutherland, J.4
  • 19
    • 0019959247 scopus 로고
    • Regulation of colonic blood flow
    • Kvietys, P.R.; Granger, D.N. Regulation of colonic blood flow. Fed. Proc., 1982, 41, 2100-2110.
    • (1982) Fed. Proc , vol.41 , pp. 2100-2110
    • Kvietys, P.R.1    Granger, D.N.2
  • 20
    • 0019504529 scopus 로고
    • Capillary blood flow in the canine colon and other organs at normal and raised portal pressure
    • Grandihon, A.S.; Yates, J.; Shields, R. Capillary blood flow in the canine colon and other organs at normal and raised portal pressure. Gut., 1981, 22, 273-227.
    • (1981) Gut , vol.22 , pp. 273-277
    • Grandihon, A.S.1    Yates, J.2    Shields, R.3
  • 21
    • 0017662842 scopus 로고
    • Vascular responses to mechanical stimulation of the mucosa of the cat colon
    • Fasth, S.; Hulten, L.; Lundgren, 0.; Nordgren, S. Vascular responses to mechanical stimulation of the mucosa of the cat colon. Acta. Physiol. Scand., 1977, 101, 988-1049.
    • (1977) Acta. Physiol. Scand , vol.101 , pp. 988-1049
    • Fasth, S.1    Hulten, L.2    Lundgren, O.3    Nordgren, S.4
  • 22
    • 0025601658 scopus 로고
    • Short chain fatty acids dilate isolated human colonic resistance arteries
    • Mortensen, F.V.; Nielsen, H.; Mulvany, M.J.; Liessov, I. Short chain fatty acids dilate isolated human colonic resistance arteries. Gut., 1990, 131, 1391-l394.
    • (1990) Gut , vol.131
    • Mortensen, F.V.1    Nielsen, H.2    Mulvany, M.J.3    Liessov, I.4
  • 23
    • 0019449068 scopus 로고
    • Effect of volatile fatty acids, on blood flow and oxygen uptake by dog colon
    • Kvietqs, P.R.; Granger, D.N. Effect of volatile fatty acids, on blood flow and oxygen uptake by dog colon. Gastroenterology, 1981, 80, 962-969.
    • (1981) Gastroenterology , vol.80 , pp. 962-969
    • Kvietqs, P.R.1    Granger, D.N.2
  • 24
    • 79953691145 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in colon cancer
    • Erik, C. Von. Rosenvinge.; Jean-Pierre, Raufman. Muscarinic receptor signaling in colon cancer. Cancers, 2011, 3,971-981.
    • (2011) Cancers , vol.3 , pp. 971-981
    • von Rosenvinge, E.C.1    Jean-Pierre, R.2
  • 25
    • 0036022631 scopus 로고    scopus 로고
    • Pharmacological evidence for putative CCK1 receptor heterogeneity in human colon smooth muscle
    • Morton, F.; Harper, E.A.; Tavares, I.A.; Shankley, N.P. Pharmacological evidence for putative CCK1 receptor heterogeneity in human colon smooth muscle. Br. J. Pharmacol., 2002, 136, 873-882.
    • (2002) Br. J. Pharmacol , vol.136 , pp. 873-882
    • Morton, F.1    Harper, E.A.2    Tavares, I.A.3    Shankley, N.P.4
  • 26
    • 77949877661 scopus 로고    scopus 로고
    • The role of Eph receptors and ephrin ligands in colorectal cancer
    • Nirmitha, I.H.; Andrew, W.B. The role of Eph receptors and ephrin ligands in colorectal cancer. Int. J. Cancer, 2010, 126, 2003-2011.
    • (2010) Int. J. Cancer , vol.126 , pp. 2003-2011
    • Nirmitha, I.H.1    Andrew, W.B.2
  • 27
    • 61449229472 scopus 로고    scopus 로고
    • Expression of ErbB receptors and their Cognate ligands in gastric and colon cancer cell lines
    • William, K.K.;. Wu.; Timothy, T. Ming, T.; Joseph, J.; Y.S.; Zhi, J. L.; Le, Y.; Chi, H.C. Expression of ErbB receptors and their Cognate ligands in gastric and colon cancer cell lines. Anticancer Research., 2009, 29, 229-234.
    • (2009) Anticancer Research , vol.29 , pp. 229-234
    • William, K.K.1    Wu2    Timothy, T.3    Ming, T.4    Joseph, J.Y.S.5    Zhi, J.L.6    Le, Y.7    Chi, H.C.8
  • 28
    • 77951107659 scopus 로고    scopus 로고
    • Estrogen receptor β mediates the protective effects of estrogen in colon cancer
    • Maria, M.; Paola, G. Estrogen receptor β mediates the protective effects of estrogen in colon cancer. Cancer Ther., 2008, 6, 149-162.
    • (2008) Cancer Ther , vol.6 , pp. 149-162
    • Maria, M.1    Paola, G.2
  • 29
    • 0033035154 scopus 로고    scopus 로고
    • Fas/Fas ligand interaction in human colorectal hepatic metastases. A mechanism of hepatocyte destruction to facilitate local tumor invasion
    • Khong, F.Y.; Simon, C.A.; Satinder, R.; Stefan, G.H.; David, H.A. Fas/Fas ligand interaction in human colorectal hepatic metastases. A mechanism of hepatocyte destruction to facilitate local tumor invasion. Am. J. Path., 1999, 154 (3), 693-703.
    • (1999) Am. J. Path , vol.154 , Issue.3 , pp. 693-703
    • Khong, F.Y.1    Simon, C.A.2    Satinder, R.3    Stefan, G.H.4    David, H.A.5
  • 30
    • 0033851081 scopus 로고    scopus 로고
    • Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines
    • Robert, E.C.; Denis, O.; Sean, L.; Alexey, D.; Richard, V.B. Characterization of gastrin-releasing peptide and its receptor aberrantly expressed by human colon cancer cell lines. Mol. Pharmacol., 2000, 58, 601-607.
    • (2000) Mol. Pharmacol , vol.58 , pp. 601-607
    • Robert, E.C.1    Denis, O.2    Sean, L.3    Alexey, D.4    Richard, V.B.5
  • 31
    • 3042638607 scopus 로고    scopus 로고
    • Growth hormone inhibits apoptosis in human colonic cancer cell lines: Antagonistic effects of peroxisome proliferator activated receptor-γ ligands
    • Fausto, B.; Federica, U.; Francesco, R.; Dania, R.; Renato, V.; Chiara, G.; Sandra, B.; Chiara, C.; Maurizio, G.; Luigi, B.; Enio, M. growth hormone inhibits apoptosis in human colonic cancer cell lines: antagonistic effects of peroxisome proliferator activated receptor-γ ligands. Endocrinology, 2004, 145(7), 3353-3362.
    • (2004) Endocrinology , vol.145 , Issue.7 , pp. 3353-3362
    • Fausto, B.1    Federica, U.2    Francesco, R.3    Dania, R.4    Renato, V.5    Chiara, G.6    Sandra, B.7    Chiara, C.8    Maurizio, G.9    Luigi, B.10    Enio, M.11
  • 32
    • 0033910870 scopus 로고    scopus 로고
    • Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
    • Rioux, J.D.; Silverberg, M.S.; Daly, M.J.; Steinhart, A.H.; McLeod R.S.; Griffiths, A.M. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am. J. Hum. Genet., 2000, 66, 1863-1870.
    • (2000) Am. J. Hum. Genet , vol.66 , pp. 1863-1870
    • Rioux, J.D.1    Silverberg, M.S.2    Daly, M.J.3    Steinhart, A.H.4    McLeod, R.S.5    Griffiths, A.M.6
  • 33
    • 11144354272 scopus 로고    scopus 로고
    • Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    • Van Heel, D.A.; Fisher, S.A.; Kirby, A.; Daly, M.J.; Rioux, J.D.; Lewis, C.M. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum. Mol. Genet., 2004, 13, 763-770.
    • (2004) Hum. Mol. Genet , vol.13 , pp. 763-770
    • van Heel, D.A.1    Fisher, S.A.2    Kirby, A.3    Daly, M.J.4    Rioux, J.D.5    Lewis, C.M.6
  • 34
    • 0032733508 scopus 로고    scopus 로고
    • Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease
    • Souza, H.S.; Elia, C.C.S.; Spencer, J.; MacDonald, T.T. Expression of lymphocyte-endothelial receptor-ligand pairs, α4β7/MAdCAM-1 and OX40/OX40 ligand in the colon and jejunum of patients with inflammatory bowel disease. Gut, 1999, 45, 856-863.
    • (1999) Gut , vol.45 , pp. 856-863
    • Souza, H.S.1    Elia, C.C.S.2    Spencer, J.3    Macdonald, T.T.4
  • 35
    • 78650548872 scopus 로고    scopus 로고
    • MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating speci c EGF receptor ligands
    • Katharina, B.; Lei, S.; Christina, N.; Owen, M. Siggs.; S., M.; Le, Gall.; Wataru, Tomisato.; Xiaohong, L.; Xin, D.; Daniela, N. M.; Carl, P.B.; Ruce, B. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating speci c EGF receptor ligands. PNAS, 2010, 107 (46), 19967-19972.
    • (2010) PNAS , vol.107 , Issue.46 , pp. 19967-19972
    • Katharina, B.1    Lei, S.2    Christina, N.3    Siggs, O.M.S.M.4    Le, G.5    Wataru, T.6    Xiaohong, L.7    Xin, D.8    Daniela, N.M.9    Carl, P.B.10    Ruce, B.11
  • 36
    • 1842587456 scopus 로고    scopus 로고
    • Expression of notch receptors and ligands in the adult gut
    • Sander, G.R.; Powell, B.C. Expression of notch receptors and ligands in the adult gut. J. Histochem. Cytochem., 2004, 52(4), 509-516.
    • (2004) J. Histochem. Cytochem , vol.52 , Issue.4 , pp. 509-516
    • Sander, G.R.1    Powell, B.C.2
  • 38
    • 33746159991 scopus 로고    scopus 로고
    • PPAR γ in colonic epithelial cells protects against experimental inflammatory bowel disease
    • Adachi, M.; Kurotani, R.; Morimura, K. PPAR γ in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut., 2006, 55, 1104-1113.
    • (2006) Gut , vol.55 , pp. 1104-1113
    • Adachi, M.1    Kurotani, R.2    Morimura, K.3
  • 39
    • 84862296372 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ and colorectal cancer
    • Yun, D.; Wei-Hong, W. Peroxisome proliferator-activated receptor γ and colorectal cancer. World J. Gastrointest. Oncol., 2010, 2(3), 159-164.
    • (2010) World J. Gastrointest. Oncol , vol.2 , Issue.3 , pp. 159-164
    • Yun, D.1    Wei-Hong, W.2
  • 40
    • 41649111966 scopus 로고    scopus 로고
    • The antiapoptotic role of pregnane X receptor in human colon cancer cells
    • Zhou, J.; Liu, M.; Zhai, Y.; Xie, W. The antiapoptotic role of pregnane X receptor in human colon cancer cells. Mol. Endocrinol., 2008, 22, 868-880.
    • (2008) Mol. Endocrinol , vol.22 , pp. 868-880
    • Zhou, J.1    Liu, M.2    Zhai, Y.3    Xie, W.4
  • 41
    • 79958126320 scopus 로고    scopus 로고
    • Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer
    • Phrabha, S.R.; Christina, S. A.; Denis, W.; Konstantinos, K. Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer. J. Cell Sci., 2011, 124 (11), 1903-1910.
    • (2011) J. Cell Sci , vol.124 , Issue.11 , pp. 1903-1910
    • Phrabha, S.R.1    Christina, S.A.2    Denis, W.3    Konstantinos, K.4
  • 42
    • 0025917690 scopus 로고
    • NK2 tachykinin receptors and contraction of circular muscle of the human colon, characterisation of the NK2 receptor subtype
    • Giuliani, S.; Barbanti, G.; Turini, D.; Quartara, L.; Rovero, P.; Giachetti, A.; Maggi, C.A. NK2 tachykinin receptors and contraction of circular muscle of the human colon, characterisation of the NK2 receptor subtype. Eur. J. Pharmacol., 1991, 203, 365-370.
    • (1991) Eur. J. Pharmacol , vol.203 , pp. 365-370
    • Giuliani, S.1    Barbanti, G.2    Turini, D.3    Quartara, L.4    Rovero, P.5    Giachetti, A.6    Maggi, C.A.7
  • 44
    • 0031875770 scopus 로고    scopus 로고
    • In vitro characterisation of tachykinin NK2 receptor modulating motor responses of human colonic muscle strips
    • Croci, T.; Aureggi, G.; Manara, L.; Emonds-Alt, X.; Le Fur, G.; Maffrand, J.P.; Mukenge, S.; Ferla, G. In vitro characterisation of tachykinin NK2 receptor modulating motor responses of human colonic muscle strips. Br. J. Pharmacol., 1998, 124, 1321-1327.
    • (1998) Br. J. Pharmacol , vol.124 , pp. 1321-1327
    • Croci, T.1    Aureggi, G.2    Manara, L.3    Emonds-Alt, X.4    Le, F.G.5    Maffrand, J.P.6    Mukenge, S.7    Ferla, G.8
  • 45
    • 0034234774 scopus 로고    scopus 로고
    • Gq-linked NK2 receptors mediate neurally induced contraction of human sigmoid circular smooth muscle
    • Cao, W.; Pricolo, V.E.; Zhang, L.; Behar, J.; Biancani, P.; Kirber, M.T. Gq-linked NK2 receptors mediate neurally induced contraction of human sigmoid circular smooth muscle. Gastroenterology, 2000, 119, 51-61.
    • (2000) Gastroenterology , vol.119 , pp. 51-61
    • Cao, W.1    Pricolo, V.E.2    Zhang, L.3    Behar, J.4    Biancani, P.5    Kirber, M.T.6
  • 46
    • 0023214646 scopus 로고
    • Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases
    • Koch, T.R.; Carney, J.A.; Go, V.L. Distribution and quantitation of gut neuropeptides in normal intestine and inflammatory bowel diseases. Dig. Dis. Sci., 1989, 32, 369-376.
    • (1989) Dig. Dis. Sci , vol.32 , pp. 369-376
    • Koch, T.R.1    Carney, J.A.2    Go, V.L.3
  • 47
    • 0005061019 scopus 로고
    • Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease
    • Mantyh, C.R.; Gates, T.S.; Zimmerman, R.P.; Welton, M.L.; Passaro, Jr. E.P.; Vigna, S.R.; Maggio, J.E.; Kruger, L.; Mantyh, P.W. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc. Natl. Acad. Sci. USA., 1988, 85, 3235-3239.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 3235-3239
    • Mantyh, C.R.1    Gates, T.S.2    Zimmerman, R.P.3    Welton, M.L.4    Passaro, E.P.5    Vigna, S.R.6    Maggio, J.E.7    Kruger, L.8    Mantyh, P.W.9
  • 48
    • 0024390476 scopus 로고
    • Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation
    • Goldin, E.; Karmeli, F.; Selinger, Z.; Rachmilewitz, D. Colonic substance P levels are increased in ulcerative colitis and decreased in chronic severe constipation. Dig. Dis. Sci., 1989, 34,754-357.
    • (1989) Dig. Dis. Sci , vol.34 , pp. 754-757
    • Goldin, E.1    Karmeli, F.2    Selinger, Z.3    Rachmilewitz, D.4
  • 50
    • 0034075041 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients
    • Lee, J.C.; Chow, N.H.; Wang, S.T.; Huang, S.M. Prognostic value of vascular endothelial growth factor expression in colorectal cancer patients. Eur. J. Cancer., 2000, 36(6), 748-753.
    • (2000) Eur. J. Cancer , vol.36 , Issue.6 , pp. 748-753
    • Lee, J.C.1    Chow, N.H.2    Wang, S.T.3    Huang, S.M.4
  • 51
    • 0037067756 scopus 로고    scopus 로고
    • Vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand
    • Bettoun, D.J.; Buck, 2nd D.W.; Lu, J.; Khalifa, B.; Chin, W.W.; Nagpal, S. A. Vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand. J. Biol. Chem., 2002, 277, 24847-24850.
    • (2002) J. Biol. Chem , vol.277 , pp. 24847-24850
    • Bettoun, D.J.1    Buck, D.W.2    Lu, J.3    Khalifa, B.4    Chin, W.W.5    Nagpal, S.A.6
  • 52
    • 0033125538 scopus 로고    scopus 로고
    • Novel 19-nor-hexafluoride vitamin D3 analog (Ro 25-6760) inhibits human colon cancer in vitro via apoptosis
    • Evans, S.R.T.; Soldatenkov, V.; Shchepotin, E.B.; Bogrash, E.; Shechepotin, I.B. Novel 19-nor-hexafluoride vitamin D3 analog (Ro 25-6760) inhibits human colon cancer in vitro via apoptosis. Int. J. Oncol., 1999, 14, 979-985.
    • (1999) Int. J. Oncol , vol.14 , pp. 979-985
    • Evans, S.R.T.1    Soldatenkov, V.2    Shchepotin, E.B.3    Bogrash, E.4    Shechepotin, I.B.5
  • 54
    • 0000044721 scopus 로고
    • Inhibition of motility induced by the activation of 5-HT1 and 5-HT4 receptor types in isolated human colon smooth muscle
    • Hillier, K.; Tam, F.S.F.; Bunce, K.T.; Grossman, C. Inhibition of motility induced by the activation of 5-HT1 and 5-HT4 receptor types in isolated human colon smooth muscle. Br. J. Pharm., 1994, 112, 102.
    • (1994) Br. J. Pharm , vol.112 , pp. 102
    • Hillier, K.1    Tam, F.S.F.2    Bunce, K.T.3    Grossman, C.4
  • 55
    • 0029058239 scopus 로고
    • A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum
    • McLean, P.G.; Coupar, I.M.; Molenaar, P. A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum. Br. J. Pharm., 1995, 115, 47-56.
    • (1995) Br. J. Pharm , vol.115 , pp. 47-56
    • McLean, P.G.1    Coupar, I.M.2    Molenaar, P.3
  • 56
    • 0027991689 scopus 로고
    • Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle
    • Tam, F.S.; Hillier, K.; Bunce, K.T. Characterization of the 5-hydroxytryptamine receptor type involved in inhibition of spontaneous activity of human isolated colonic circular muscle. Br. J. Pharm., 1994, 113, 143-150.
    • (1994) Br. J. Pharm , vol.113 , pp. 143-150
    • Tam, F.S.1    Hillier, K.2    Bunce, K.T.3
  • 57
    • 0028989385 scopus 로고
    • Differences in responses to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle
    • Tam, F.S.; Hillier, K.; Bunce, K.T.; Grossman, C. Differences in responses to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. Br. J. Pharm., 1995, 115, 172-176.
    • (1995) Br. J. Pharm , vol.115 , pp. 172-176
    • Tam, F.S.1    Hillier, K.2    Bunce, K.T.3    Grossman, C.4
  • 58
    • 0028985736 scopus 로고
    • Functional evidence for a 5-HT2B receptor mediating contraction of longitudinal muscle in human small intestine
    • Borman, R.A.; Burleigh, D.E. Functional evidence for a 5-HT2B receptor mediating contraction of longitudinal muscle in human small intestine. Br. J. Pharm., 1995, 114, 1525-1527.
    • (1995) Br. J. Pharm , vol.114 , pp. 1525-1527
    • Borman, R.A.1    Burleigh, D.E.2
  • 59
    • 0034670390 scopus 로고    scopus 로고
    • Adenosine A1 receptor blockade reverses dysmotility induced by ischemia-reperfusion in rat colon
    • Makoto, K.; Kenichi, T.; Yasunori, N.; Masahiro, T.; Kaori, H.; Masaaki, T. Adenosine A1 receptor blockade reverses dysmotility induced by ischemia-reperfusion in rat colon. Eur. J. Pharmacol., 2000, 409, 319-323.
    • (2000) Eur. J. Pharmacol , vol.409 , pp. 319-323
    • Makoto, K.1    Kenichi, T.2    Yasunori, N.3    Masahiro, T.4    Kaori, H.5    Masaaki, T.6
  • 62
    • 0030433064 scopus 로고    scopus 로고
    • Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth
    • Iwase, K.; Evers, B.M.; Hellmich, M.R.; Kim, H.J.; Higashide, S.T.; Gully, D.; Townsend, Jr. C.M. Indirect inhibitory effect of a neurotensin receptor antagonist on human colon cancer (LoVo) growth. Surg. Oncol., 1996, 5, 245-251.
    • (1996) Surg. Oncol , vol.5 , pp. 245-251
    • Iwase, K.1    Evers, B.M.2    Hellmich, M.R.3    Kim, H.J.4    Higashide, S.T.5    Gully, D.6    Townsend, C.M.7
  • 63
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • doi: 10.1073/pnas.1006451107
    • Malin, E.V.J.; Jessica, M.H.L.; Gunnar, C.H. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. PNAS, 2010, doi: 10.1073/pnas.1006451107.
    • (2010) PNAS
    • Malin, E.V.J.1    Jessica, M.H.L.2    Gunnar, C.H.3
  • 64
    • 0034519669 scopus 로고    scopus 로고
    • Microbial modulation of host intestinal glycosylation patterns
    • Miguel, Freitas.; Chantal, C. Microbial modulation of host intestinal glycosylation patterns. Microbial. Ecol. Health Dis., 2000, 2, 165-178.
    • (2000) Microbial. Ecol. Health Dis , vol.2 , pp. 165-178
    • Miguel, F.1    Chantal, C.2
  • 68
    • 0033566850 scopus 로고    scopus 로고
    • Two novel mucin genes down-regulated in colorectal cancer identified by differential display
    • Williams, S.J.; McGuckin, M.A.; Gotley, D.C.; Eyre, H.J.; Sutherland, G.R.; Antalis, T.M. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res., 1999, 59, 4083-4089.
    • (1999) Cancer Res , vol.59 , pp. 4083-4089
    • Williams, S.J.1    McGuckin, M.A.2    Gotley, D.C.3    Eyre, H.J.4    Sutherland, G.R.5    Antalis, T.M.6
  • 69
    • 0033105407 scopus 로고    scopus 로고
    • Complete sequence of the human mucin MUC4, a putative cell membrane-associated mucin
    • Moniaux, N.; Nollet, S.; Degand, P.; Laine, A.; Aubert, J.P. Complete sequence of the human mucin MUC4, a putative cell membrane-associated mucin. Biochem. J., 1999, 338, 325-333.
    • (1999) Biochem. J , vol.338 , pp. 325-333
    • Moniaux, N.1    Nollet, S.2    Degand, P.3    Laine, A.4    Aubert, J.P.5
  • 71
    • 0035920171 scopus 로고    scopus 로고
    • Molecular cloning of the CA125 ovarian cancer antigen
    • Yin, B.W.T.; Lloyd, K. Molecular cloning of the CA125 ovarian cancer antigen. J. Biol. Chem., 2001, 276, 27371-27375.
    • (2001) J. Biol. Chem , vol.276 , pp. 27371-27375
    • Yin, B.W.T.1    Lloyd, K.2
  • 75
    • 0026802436 scopus 로고
    • The human MUC2 intestinal mucin has cysteinerich subdomains located both upstream and downstream of its central repetitive region
    • Gum, J.R.; Hicks, J.W.; Toribara, N.W.; Rothe, E.M.; Lagace, R.E.; Kim, Y.S. The human MUC2 intestinal mucin has cysteinerich subdomains located both upstream and downstream of its central repetitive region. J. Biol. Chem., 1992, 267, 21375-21383.
    • (1992) J. Biol. Chem , vol.267 , pp. 21375-21383
    • Gum, J.R.1    Hicks, J.W.2    Toribara, N.W.3    Rothe, E.M.4    Lagace, R.E.5    Kim, Y.S.6
  • 76
    • 0032514921 scopus 로고    scopus 로고
    • Genomic organization of the human mucin gene MUC5B-cDNA and genomic sequences upstream of the large central exon
    • Desseyn, J.L.; Buisine, M.P.; Porchet, N.; Aubert, J.P.; Laine, A. Genomic organization of the human mucin gene MUC5B-cDNA and genomic sequences upstream of the large central exon. J. Biol. Chem., 1998, 273, 30157-30164.
    • (1998) J. Biol. Chem , vol.273 , pp. 30157-30164
    • Desseyn, J.L.1    Buisine, M.P.2    Porchet, N.3    Aubert, J.P.4    Laine, A.5
  • 77
    • 0032549673 scopus 로고    scopus 로고
    • Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts
    • Li, D.Z.; Gallup, M.; Fan, N.; Szymkowski, D.E.; Basbaum, C.B. Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J. Biol. Chem., 1998, 273, 6812-6820.
    • (1998) J. Biol. Chem , vol.273 , pp. 6812-6820
    • Li, D.Z.1    Gallup, M.2    Fan, N.3    Szymkowski, D.E.4    Basbaum, C.B.5
  • 78
    • 0024592945 scopus 로고
    • Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism
    • Gum, J.R.; Byrd, J.C.; Hicks, J.W.; Toribara, N.W.; Lamport, D.T.; Kim, Y.S. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism. J. Biol. Chem., 1989, 264, 6480-6487.
    • (1989) J. Biol. Chem , vol.264 , pp. 6480-6487
    • Gum, J.R.1    Byrd, J.C.2    Hicks, J.W.3    Toribara, N.W.4    Lamport, D.T.5    Kim, Y.S.6
  • 79
    • 0028106680 scopus 로고
    • Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor
    • Gum, J.R.; Hicks, J.W.; Toribara, N.W.; Siddiki, B.; Kim, Y.S. Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor. J. Biol. Chem., 1994, 269, 2440-2446.
    • (1994) J. Biol. Chem , vol.269 , pp. 2440-2446
    • Gum, J.R.1    Hicks, J.W.2    Toribara, N.W.3    Siddiki, B.4    Kim, Y.S.5
  • 81
    • 0038751861 scopus 로고    scopus 로고
    • An autocatalytic cleavage in the C-terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway
    • Lidell, M.E.; Johansson, M.E.V.; Hansson, G.C. An autocatalytic cleavage in the C-terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. J. Biol. Chem., 2003, 278, 13944-13951.
    • (2003) J. Biol. Chem , vol.278 , pp. 13944-13951
    • Lidell, M.E.1    Johansson, M.E.V.2    Hansson, G.C.3
  • 82
    • 0034613156 scopus 로고    scopus 로고
    • The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha-inhibitor heavy chain precursor
    • Thuveson, M.; Fries, E. The low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha-inhibitor heavy chain precursor. J. Biol. Chem., 2000, 275, 30996-31000.
    • (2000) J. Biol. Chem , vol.275 , pp. 30996-31000
    • Thuveson, M.1    Fries, E.2
  • 83
    • 33745121509 scopus 로고    scopus 로고
    • Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal part and dissolves the protective colonic mucus gel
    • Lidell, M.E.; Moncada, D.M.; Chadee, K.; Hansson, G.C. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal part and dissolves the protective colonic mucus gel. Proc. Natl. Acad. Sci. U. S. A., 2006, 103, 9298-9393.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 9298-9393
    • Lidell, M.E.1    Moncada, D.M.2    Chadee, K.3    Hansson, G.C.4
  • 86
    • 33646265743 scopus 로고    scopus 로고
    • The front line of enteric host defense against unwelcome intrusion of harmful microorganisms, mucins, antimicrobial peptides and microbiota
    • Lievin-Le Moal, V.; Servin, A.L. The front line of enteric host defense against unwelcome intrusion of harmful microorganisms, mucins, antimicrobial peptides and microbiota. Clin. Microbiol. Rev., 2006, 19,315-37.
    • (2006) Clin. Microbiol. Rev , vol.19 , pp. 315-337
    • Lievin-Le, M.V.1    Servin, A.L.2
  • 87
    • 0038237678 scopus 로고    scopus 로고
    • Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro
    • Mack, D.R.; Ahrne, S.; Hyde, L.; Wei, S.; Hollingsworth, M.A. Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro. Gut, 2003, 52,827-33.
    • (2003) Gut , vol.52 , pp. 827-833
    • Mack, D.R.1    Ahrne, S.2    Hyde, L.3    Wei, S.4    Hollingsworth, M.A.5
  • 88
    • 0034023665 scopus 로고    scopus 로고
    • Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
    • Barcelo, A.; Claustre, J.; Moro, F.; Chayvialle, J.A.; Cuber, J.C.; Plaisancie, P. Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon. Gut, 2000, 46, 218-24.
    • (2000) Gut , vol.46 , pp. 218-224
    • Barcelo, A.1    Claustre, J.2    Moro, F.3    Chayvialle, J.A.4    Cuber, J.C.5    Plaisancie, P.6
  • 89
    • 1842583017 scopus 로고    scopus 로고
    • Mucin dynamics in the chick small intestine are altered by starvation
    • Smirnov, A.; Sklan, D.; Uni, Z. Mucin dynamics in the chick small intestine are altered by starvation. J. Nutr., 2004, 134, 736-42.
    • (2004) J. Nutr , vol.134 , pp. 736-742
    • Smirnov, A.1    Sklan, D.2    Uni, Z.3
  • 90
    • 0021874008 scopus 로고
    • Stimulation of intestinal cytokinetics and mucin turnover in rats fed wheat bran or cellulose
    • Vahouny, G.; Le, T.; Ifrim, I.; Satchithanandam, S.; Cassidy, M. Stimulation of intestinal cytokinetics and mucin turnover in rats fed wheat bran or cellulose. Am. J. Clin. Nutr., 1985, 41, 895-900.
    • (1985) Am. J. Clin. Nutr , vol.41 , pp. 895-900
    • Vahouny, G.1    Le, T.2    Ifrim, I.3    Satchithanandam, S.4    Cassidy, M.5
  • 91
    • 0013932518 scopus 로고
    • Ionic constituents and osmolality of gastric and small intestinal fluids after eating
    • Fordtran, J.S.; Locklear, T.W. Ionic constituents and osmolality of gastric and small intestinal fluids after eating. Am. J. Dig. Dis., 1966, 11(7), 503-521.
    • (1966) Am. J. Dig. Dis , vol.11 , Issue.7 , pp. 503-521
    • Fordtran, J.S.1    Locklear, T.W.2
  • 92
    • 0023693299 scopus 로고
    • Measurement of gastrointestinal pH profles in normal ambulant human subjects
    • Evans, D.F.; Pye, G.; Bramley, R.; Clark, A.G.; Dyson, T.J.; Hardcastle, J.D. Measurement of gastrointestinal pH profles in normal ambulant human subjects. Gut, 1988, 29, 1035-1041.
    • (1988) Gut , vol.29 , pp. 1035-1041
    • Evans, D.F.1    Pye, G.2    Bramley, R.3    Clark, A.G.4    Dyson, T.J.5    Hardcastle, J.D.6
  • 93
    • 84970832405 scopus 로고
    • pH profile of gut as measured by radiotelemetry capsule
    • Meldrum, S.J.; Watson, B.W.; Riddle, H.C. pH profile of gut as measured by radiotelemetry capsule. Br. Med. J., 1972, 2, 104-106.
    • (1972) Br. Med. J , vol.2 , pp. 104-106
    • Meldrum, S.J.1    Watson, B.W.2    Riddle, H.C.3
  • 94
    • 0027369958 scopus 로고
    • An evaluation of pectin as a carrier for drug targeting to the colon
    • Ashord, M.; Fell, J.T.; Attwood, D.; Sharma, H.; Woodhead, P. An evaluation of pectin as a carrier for drug targeting to the colon. J. Control. Rel., 1993, 26, 213-220.
    • (1993) J. Control. Rel , vol.26 , pp. 213-220
    • Ashord, M.1    Fell, J.T.2    Attwood, D.3    Sharma, H.4    Woodhead, P.5
  • 97
    • 0025734920 scopus 로고
    • Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects
    • Coupe, A.J.; Davis, S.S.; Wilding, I.R. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res., 1991, 8, 360-364.
    • (1991) Pharm. Res , vol.8 , pp. 360-364
    • Coupe, A.J.1    Davis, S.S.2    Wilding, I.R.3
  • 98
    • 84870179021 scopus 로고    scopus 로고
    • Colon targeted drug delivery using different approaches
    • Sharma, A.; Jain, K.A. Colon targeted drug delivery using different approaches. Int. J. Pharm. Stu. Res., 2010, 1(1), 60-66.
    • (2010) Int. J. Pharm. Stu. Res , vol.1 , Issue.1 , pp. 60-66
    • Sharma, A.1    Jain, K.A.2
  • 100
    • 0027485241 scopus 로고
    • Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea
    • Vonderohe, M.R.; Camolleri, M.; Kvols, L.K.; Thomforde, G.M. Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. New Eng. J. Med., 1993, 329, 1073-1078.
    • (1993) New Eng. J. Med , vol.329 , pp. 1073-1078
    • Vonderohe, M.R.1    Camolleri, M.2    Kvols, L.K.3    Thomforde, G.M.4
  • 101
    • 68149165782 scopus 로고    scopus 로고
    • Characterisation of the contents of the ascending colon to which drugs are exposed after oral administration to healthy adults
    • Diakidou, A.; Vertzoni, M.; Goumas, K.; Abrahamsson, B.; Söderlind, E.; Dressman, J.B.; Reppas, C. Characterisation of the contents of the ascending colon to which drugs are exposed after oral administration to healthy adults. Pharm. Res., 2009, 26, 2141-2151.
    • (2009) Pharm. Res , vol.26 , pp. 2141-2151
    • Diakidou, A.1    Vertzoni, M.2    Goumas, K.3    Abrahamsson, B.4    Söderlind, E.5    Dressman, J.B.6    Reppas, C.7
  • 102
    • 0021328175 scopus 로고
    • Intestinal flora in health and disease
    • Simon, G.L.; Gorbach, S.L. Intestinal flora in health and disease. Gastroenterology, 1984, 86, 174-193.
    • (1984) Gastroenterology , vol.86 , pp. 174-193
    • Simon, G.L.1    Gorbach, S.L.2
  • 104
    • 0025855242 scopus 로고
    • The control and consequences of bacterial fermentation in the human colon
    • Cummings, J.H.; Macfarlane, G.T. The control and consequences of bacterial fermentation in the human colon. J. Appl. Bacterial., 1991, 70, 443-459.
    • (1991) J. Appl. Bacterial , vol.70 , pp. 443-459
    • Cummings, J.H.1    Macfarlane, G.T.2
  • 105
    • 0025050623 scopus 로고
    • Microbially controlled drug delivery to the colon
    • Rubunstein, A. Microbially controlled drug delivery to the colon. Biopharm. Drug Dispos., 1990, 11, 465-475.
    • (1990) Biopharm. Drug Dispos , vol.11 , pp. 465-475
    • Rubunstein, A.1
  • 106
    • 0023213832 scopus 로고
    • Fermentation in the human large intestine and available substrates
    • Cummings, J.H.; Englyst, H.N. Fermentation in the human large intestine and available substrates. Am. J. Clin. Nutr., 1987, 45, 1243-1255.
    • (1987) Am. J. Clin. Nutr , vol.45 , pp. 1243-1255
    • Cummings, J.H.1    Englyst, H.N.2
  • 108
    • 0008926709 scopus 로고
    • Oral drug delivery and delivery systems
    • Chien Y.W., ed, New York, Marcel Dekker Inc
    • Chien, Y.W. Oral drug delivery and delivery systems. In, Chien Y.W., ed. Novel drug delivery systems. New York, Marcel Dekker Inc, 1992, 139-196.
    • (1992) Novel Drug Delivery Systems , pp. 139-196
    • Chien, Y.W.1
  • 109
    • 0015757745 scopus 로고
    • Metabolism of foreign compounds by gastrointestinal microorganisms
    • Scheline, R.R. Metabolism of foreign compounds by gastrointestinal microorganisms. Pharmacol. Rev., 1973, 25, 451-523.
    • (1973) Pharmacol. Rev , vol.25 , pp. 451-523
    • Scheline, R.R.1
  • 110
    • 0028860545 scopus 로고
    • Azopolymeric hydrogels for colon targeted drug delivery
    • Shanta, K.L.; Ravichandran, P.; Rao, K.P. Azopolymeric hydrogels for colon targeted drug delivery. Biomaterials, 1995, 16, 1313-1318.
    • (1995) Biomaterials , vol.16 , pp. 1313-1318
    • Shanta, K.L.1    Ravichandran, P.2    Rao, K.P.3
  • 111
    • 0026744322 scopus 로고
    • Chondroitin sulphate, A potential biodegradable carrier for colon-specific drug delivery
    • Rubinstin, A.; Nakar, D.; Sintov, A. Chondroitin sulphate, A potential biodegradable carrier for colon-specific drug delivery. Int. J. Pharm., 1992, 84, 141-150.
    • (1992) Int. J. Pharm , vol.84 , pp. 141-150
    • Rubinstin, A.1    Nakar, D.2    Sintov, A.3
  • 113
    • 38649115342 scopus 로고    scopus 로고
    • Microbial influences in inflammatory bowel diseases
    • Sartor, R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology, 2008, 134, 577-594.
    • (2008) Gastroenterology , vol.134 , pp. 577-594
    • Sartor, R.B.1
  • 114
    • 0033136072 scopus 로고    scopus 로고
    • Coated dosage forms for colon-specific drug delivery
    • Claudia, S. Leopold. Coated dosage forms for colon-specific drug delivery. PSTT, 1999, 2(5), 197-204.
    • (1999) PSTT , vol.2 , Issue.5 , pp. 197-204
    • Leopold, C.S.1
  • 116
    • 0028122960 scopus 로고
    • Oral Chronotopic® drug delivery systems: Achievement of time and/or site specificity
    • Gazzaniga, A.; Sangalli, M.E.; Giordano, F. Oral Chronotopic® drug delivery systems: achievement of time and/or site specificity. Eur. J. Pharm. Biopharm., 1994, 40, 246-250.
    • (1994) Eur. J. Pharm. Biopharm , vol.40 , pp. 246-250
    • Gazzaniga, A.1    Sangalli, M.E.2    Giordano, F.3
  • 119
    • 0037965685 scopus 로고    scopus 로고
    • Organic Redox-initiated polymerization process for the fabrication of hydrogels for colonspecific drug delivery
    • Emmanuel, O.; Akala, O.E.; Vantoria, C. Organic Redox-initiated polymerization process for the fabrication of hydrogels for colonspecific drug delivery. Drug Develop. Industrial Pharmacy, 2003, 29(4), 375-386.
    • (2003) Drug Develop. Industrial Pharmacy , vol.29 , Issue.4 , pp. 375-386
    • Emmanuel, O.1    Akala, O.E.2    Vantoria, C.3
  • 120
    • 2942566668 scopus 로고    scopus 로고
    • Multiparticulate chitosan dispersed system for drug delivery
    • Norihito, S.; Toshihto, T.; Masumi, V. Multiparticulate chitosan dispersed system for drug delivery. Chem. Pharm. Bull., 2003, 51 (6), 620-624.
    • (2003) Chem. Pharm. Bull , vol.51 , Issue.6 , pp. 620-624
    • Norihito, S.1    Toshihto, T.2    Masumi, V.3
  • 121
    • 0029887876 scopus 로고    scopus 로고
    • In vitro degradation by colonic bacteria on inulin HP incorporated in Eudragit® RS films
    • Vervoort, L.; Kinget, R. In vitro degradation by colonic bacteria on inulin HP incorporated in Eudragit® RS films. Int. J. Pharm., 1996, 129, 185-190.
    • (1996) Int. J. Pharm , vol.129 , pp. 185-190
    • Vervoort, L.1    Kinget, R.2


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