Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin

Free Radical Biology and Medicine

Volumn 53, Issue 12, 2012, Pages 2229-2239

  Solomon, Steven B ^a,b   Bellavia, Landon ^b   Sweeney, Daniel ^a   Piknova, Barbora ^d   Perlegas, Andreas ^b   Helms, Christine C ^b,c   Ferreyra, Gabriela A ^a   Bruce King, S ^b   Raat, Nicolaas J H ^e,f   Kern, Steven J ^a   Sun, Junfeng ^a   McPhail, Linda C ^g   Schechter, Alan N ^d   Natanson, Charles ^a   Gladwin, Mark T ^e,f   Kim Shapiro, Daniel B ^b,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Department of Physics ^*  (United States)

^c WAKE FOREST UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e Vascular Medicine Institute   (United States)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Angeli's salt; Cell free hemoglobin; Free radicals; Methemoglobin; Nitroxyl

Indexed keywords

ANGELI SALT; HEMOGLOBIN; METHEMOGLOBIN; NITRITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; VASOCONSTRICTION; VASODILATATION;

EID: 84870211351     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.548     Document Type: Article

References (58)

1. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial-cells in the relaxation of arterial smooth-muscle by acetylcholine Nature 288 1980 373 376 (Pubitemid 11169009)
2. L.J. Ignarro, R.E. Byrns, G.M. Buga, and K.S. Wood Endothelium-derived relaxing factor from pulmonary-artery and vein possesses pharmacological and chemical-properties identical to those of nitric-oxide radical Circ. Res. 61 1987 866 879 (Pubitemid 18004583)
3. S. Katsuki, W. Arnold, C. Mittal, and F. Murad Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric-oxide in various tissue preparations and comparison to effects of sodium azide and hydroxylamine J. Cyclic Nucleotide Res 3 1977 23 35 (Pubitemid 8078230)
4. R.M.J. Palmer, A.G. Ferrige, and S. Moncada Nitric-oxide release accounts for the biological-activity of endothelium-derived relaxing factor Nature 327 1987 524 526 (Pubitemid 17085822)
5. L.J. Ignarro Nitric Oxide Biology and Pathobiology 2000 Academic Press San Diego
6. E.M. Battinelli, and J. Loscalzo Nitric oxide and platelet-mediated hemostasis J. Loscalzo, J.A. Vita, Nitric Oxide and the Cardiovascular System 2000 Humana Press Totowa, NJ 123 138
7. J. Loscalzo Nitric oxide insufficiency, platelet activation, and arterial thrombosis Circ. Res. 88 2001 756 762 (Pubitemid 32429970)
8. S. Nakashima, T. Tohmatsu, H. Hattori, Y. Okano, and Y. Nozawa Inhibitory action of cyclic GMP on secretion, polyphosphoinositide hydrolysis and calcium mobilization in thrombin-stimulated human platelets Biochem. Biophys. Res. Commun. 135 1986 1099 1104 (Pubitemid 16040011)
9. P. Kubes, M. Suzuki, and D.N. Granger Nitric oxide: an endogenous modulator of leukocyte adhesion Proc. Natl. Acad. Sci. USA 88 1991 4651 4655 (Pubitemid 21914599)
10. A. Tailor, and D.N. Granger Role of adhesion molecules in vascular regulation and damage Curr. Hypertens. Rep. 2 2000 78 83
11. M.J. Hickey, and P. Kubes Role of nitric oxide in regulation of leucocyte-endothelial cell interactions Exp. Physiol. 82 1997 339 348 (Pubitemid 27182311)
12. J.R. Lancaster Simulation of the diffusion and reaction of endogenously produced nitric-oxide Proc. Natl. Acad. Sci. USA 91 1994 8137 8141
13. K.T. Huang, Z. Huang, and D.B. Kim-Shapiro Nitric oxide red blood cell membrane permeability at high and low oxygen tension Nitric Oxide 16 2007 209 216 (Pubitemid 46149397)
14. D.H. Doherty, M.P. Doyle, S.R. Curry, R.J. Vali, T.J. Fattor, J.S. Olson, and D.D. Lemon Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin Nat. Biotechnol. 16 1998 672 676 (Pubitemid 28334327)
15. •-mediated oxidation of oxymyoglobin and oxyhemoglobin Biochemistry 40 2001 3385 3395 (Pubitemid 32221642)
16. A.R. Butler, I.L. Megson, and P.G. Wright Diffusion of nitric oxide and scavenging by blood in the vasculature Biochim. Biophys. Acta 1425 1998 168 176 (Pubitemid 28479723)
17. X.P. Liu, A. Samouilov, J.R. Lancaster, and J.L. Zweier Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance J. Biol. Chem. 277 2002 26194 26199 (Pubitemid 34967106)
18. I. Azarov, K.T. Huang, S. Basu, M.T. Gladwin, N. Hogg, and D.B. Kim-Shapiro Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation J. Biol. Chem. 280 2005 39024-38032
19. I. Azarov, C. Liu, H. Reynolds, Z. Tsekouras, J.S. Lee, M.T. Gladwin, and D.B. Kim-Shapiro Mechanisms of slower nitric oxide uptake by red blood cells and other hemoglobin-containing vesicles J. Biol. Chem. 286 2011 33567 33579
20. M.W. Vaughn, K.T. Huang, L. Kuo, and J.C. Liao Erythrocytes possess an intrinsic barrier to nitric oxide consumption J. Biol. Chem. 275 2000 2342 2348 (Pubitemid 30081991)
21. A. Jeffers, M.T. Gladwin, and D.B. Kim-Shapiro Computation of plasma hemoglobin nitric oxide scavenging in hemolytic anemias Free Radic. Biol. Med. 41 2006 1557 1565 (Pubitemid 44550083)
22. C. Donadee, N.J.H. Raat, T. Kanias, J. Tejero, J.S. Lee, E.E. Kelley, X. Zhao, C. Liu, H. Reynolds, I. Azarov, S. Frizzell, E.M. Meyer, A.D. Donnenberg, L. Qu, D. Triulzi, D.B. Kim-Shapiro, and M.T. Gladwin Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion Circulation 124 2011 465 476
23. U. Pohl, and D. Lamontagne Impaired tissue perfusion after inhibition of endothelium-derived nitric-oxide Basic Res. Cardiol. 86 1991 97 105
24. J.R. Hess, V.W. Macdonald, and W.W. Brinkley Systemic and pulmonary-hypertension after resuscitation with cell-free hemoglobin J. Appl. Physiol. 74 1993 1769 1778 (Pubitemid 23133473)
25. R. Lee, K. Neya, T.A. Svizzero, and G.J. Vlahakes Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions J. Appl. Physiol. 79 1995 236 242
26. Y. Dou, D.H. Maillett, R.F. Eich, and J.S. Olson Myoglobin as a model system for designing heme protein based blood substitutes Biophys. Chem. 98 2002 127 148 (Pubitemid 34785987)
27. J.S. Olson, E.W. Foley, C. Rogge, A.L. Tsai, M.P. Doyle, and D.D. Lemon NO scavenging and the hypertensive effect of hemoglobin-based blood substitutes Free Radic. Biol. Med. 36 2004 685 697 (Pubitemid 38264413)
28. R.P. Patel Biochemical aspects of the reaction of hemoglobin and NO: implications for Hb-based blood substitutes Free Radic. Biol. Med 28 2000 1518 1525 (Pubitemid 30604234)
29. A. Thompson, A.E. McGarry, C.R. Valeri, and W. Lieberthal Stroma-free hemoglobin increases blood-pressure and GFR in the hypotensive rat-role of nitric-oxide J. Appl. Physiol. 77 1994 2348 2354 (Pubitemid 24346444)
30. C.D. Reiter, and M.T. Gladwin An emerging role for nitric oxide in sickle cell disease vascular homeostasis and therapy Curr. Opin. Hematol. 10 2003 99 107 (Pubitemid 36207963)
31. C.D. Reiter, X.D. Wang, J.E. Tanus-Santos, N. Hogg, R.O. Cannon, A.N. Schechter, and M.T. Gladwin Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease Nat. Med 8 2002 1383 1389 (Pubitemid 36019423)
32. M.T. Gladwin Unraveling the hemolytic subphenotype of sickle cell disease Blood 106 2005 2925 2926 (Pubitemid 41565872)
33. G.J. Kato, V.R. McGowan, R.F. Machado, J.A. Little, J. Taylor VI, C.R. Morris, J.S. Nichols, X. Wang, M. Poljakovic, J. Morris, M. Sidney, and M.T. Gladwin Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension and death in patients with sickle cell disease Blood 107 2006 2279 2285 (Pubitemid 43345545)
34. M.T. Gladwin, R.J. Barst, O.L. Castro, V.R. Gordeuk, C.A. Hillery, G.J. Kato, D.B. Kim-Shapiro, R. Machado, C.R. Morris, M.H. Steinberg, and E.P. Vichinsky Pulmonary hypertension and NO in sickle cell Blood 116 2010 852 854
35. M.T. Gladwin, and D.B. Kim-Shapiro Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis Curr. Opin. Hematol. 16 2009 515 523
36. D.B. Kim-Shapiro, J. Lee, and M.T. Gladwin Storage lesion: role of red blood cell breakdown Transfusion 51 2011 844 851
37. H.F. Bunn, D.G. Nathan, G.J. Dover, R.P. Hebbel, O.S. Platt, W.F. Rosse, and R.E. Ware Pulmonary hypertension and nitric oxide depletion in sickle cell disease Blood 116 2010 687 692
38. P.W. Buehler, E. Karnaukhova, M.P. Gelderman, and A.I. Alayash Blood aging, safety, and transfusion: capturing the "radical" menace Antioxid. Redox Signaling 14 2011 1713 1728
39. A.I. Alayash Setbacks in blood substitutes research and development: a biochemical perspective Clin. Lab. Med. 30 2010 381
40. P.C. Minneci, K.J. Deans, H. Zhi, P.S.T. Yuen, R.A. Star, S.M. Banks, A.N. Schechter, C. Natanson, M.T. Gladwin, and S.B. Solomon Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin J. Clin. Invest. 115 2005 3409 3417 (Pubitemid 43121829)
41. P.C. Minneci, K.J. Deans, S. Shiva, H. Zhi, S.M. Banks, S. Kern, C. Natanson, S.B. Solomon, and M.T. Gladwin Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis Am. J. Physiol. Heart Circ. Physiol 295 2008 H743 H754
42. K. Cosby, K.S. Partovi, J.H. Crawford, R.P. Patel, C.D. Reiter, S. Martyr, B.K. Yang, M.A. Waclawiw, G. Zalos, X.L. Xu, K.T. Huang, H. Shields, D.B. Kim-Shapiro, A.N. Schechter, R.O. Cannon, and M.T. Gladwin Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation Nat. Med 9 2003 1498 1505 (Pubitemid 38004777)
43. J. Brooks The action of nitrite on haemoglobin in the absence of oxygen Proc. R. Soc. London B Biol. Sci 123 1937 368 382
44. M.P. Doyle, R.A. Pickering, T.M. Deweert, J.W. Hoekstra, and D. Pater Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites J. Biol. Chem. 256 1981 12393 12398 (Pubitemid 12141507)
45. A. Gamgee Researches on the blood: on the action of nitrites on blood Philos. Trans. R. Soc. London 158 1868 589 625
46. A. Keszler, B. Piknova, A.N. Schechter, and N. Hogg The reaction between nitrite and oxyhemoglobin J. Biol. Chem. 283 2008 9615 9622
47. B. Piknova, A. Keszler, N. Hogg, and A.N. Schechter The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: implications for nitrite-based therapies Nitric Oxide 20 2009 88 94
48. M.P. Doyle, S.N. Mahapatro, R.D. Broene, and J.K. Guy Oxidation and reduction of hemoproteins by trioxodinitrate(II)-the role of nitrosyl hydride and nitrite J. Am. Chem. Soc. 110 1988 593 599
49. K.M. Miranda, N. Paolocci, T. Katori, D.D. Thomas, E. Ford, M.D. Bartberger, M.G. Espey, D.A. Kass, M. Feelisch, J.M. Fukuto, and D.A. Wink A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system Proc. Natl. Acad. Sci. USA 100 2003 9196 9201 (Pubitemid 37033906)
50. X. He, I. Azarov, A. Jeffers, T. Presley, J. Richardson, S.B. King, M.T. Gladwin, and D.B. Kim-Shapiro The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin Free Radic. Biol. Med. 44 2008 1420 1432
51. K.M. Miranda The chemistry of nitroxyl (HNO) and implications in biology Coord. Chem. Rev. 249 2005 433 455 (Pubitemid 40093751)
52. - within the hydrophobic interior of biological membranes Proc. Natl. Acad. Sci. USA 95 1998 2175 2179 (Pubitemid 28145914)
53. G.-A.M. Lobo, S.A. Chitre, S.M. Rathod, R.B. Smith, R. Leslie, C. Livingstone, and J. Davis Determination of total reduced thiol levels in plasma using a bromide substituted quinone Electroanalysis 19 2007 2523 2528
54. E. Bermejo, D.A. Saenz, F. Alberto, R.E. Rosenstein, S.E. Bari, and M.A. Lazzari Effect of nitroxyl on human platelets function Thromb. Haemostasis 94 2005 578 584 (Pubitemid 41300855)
55. B.E. VanUffelen, J. Van der Zee, B.M. de Koster, J. VanSteveninck, and J.G.R. Elferink Intracellular but not extracellular conversion of nitroxyl anion into nitric oxide leads to stimulation of human neutrophil migration Biochem. J. 330 1998 719 722 (Pubitemid 28111968)
56. D.A. Wink, M. Feelisch, J. Fukuto, D. Chistodoulou, D. Jourd'heuil, M.B. Grisham, Y. Vodovotz, J.A. Cook, M. Krishna, W.G. DeGraff, S. Kim, J. Gamson, and J.B. Mitchell The cytotoxicity of nitroxyl: possible implications for the pathophysiological role of NO Arch. Biochem. Biophys. 351 1998 66 74 (Pubitemid 28373052)
57. C.-u. Choe, J. Lewerenz, G. Fischer, T.F. Uliasz, M.G. Espey, F.C. Hummel, S.B. King, E. Schwedhelm, R.H. Boeger, C. Gerloff, S.J. Hewett, T. Magnus, and S. Donzelli Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity J. Neurochem. 110 2009 1766 1773
58. X.L. Ma, F. Cao, G.L. Liu, B.L. Lopez, T.A. Christopher, J.M. Fukuto, D.A. Wink, and M. Feelisch Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury Proc. Natl. Acad. Sci. USA 96 1999 14617 14622 (Pubitemid 30000699)