Design and synthesis of eugenol derivatives, as potent 15-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 890-901

  Sadeghian, Hamid ^a   Seyedi, Seyed Mohammad ^a   Saberi, Mohammad Reza ^b   Arghiani, Zahra ^a   Riazi, Mehdi ^a  

^a FERDOWSI UNIVERSITY OF MASHHAD   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

15 HLOa; 15 HLOb; 4 Allyl 2 methoxyphenol; Docking; Protein modeling; Soybean lipoxygenase

Indexed keywords

15 LIPOXYGENASE INHIBITOR; 4 ALLYL 2 METHOXYPHENYL 1 ADMANTANECARBOXYLATE; 4 ALLYL 2 METHOXYPHENYL 1 CYCLOHEXANECARBOXYLATE; 4 ALLYL 2 METHOXYPHENYL 2 CHLOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 2 FLUOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 2 METHYLBENZOATE; 4 ALLYL 2 METHOXYPHENYL 2 PYRIDINECARBOXYLATE; 4 ALLYL 2 METHOXYPHENYL 3 CHLOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 3 FLUOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 3 METHOXYBENZOATE; 4 ALLYL 2 METHOXYPHENYL 3 METHYLBENZOATE; 4 ALLYL 2 METHOXYPHENYL 4 CHLOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 4 FLUOROBENZOATE; 4 ALLYL 2 METHOXYPHENYL 4 METHOXYBENZOATE; 4 ALLYL 2 METHOXYPHENYL 4 METHYLBENZOATE; 4 ALLYL 2 METHOXYPHENYL BENZOATE; 4 ALLYL 2 METHOXYPHENYL ISONICOTINATE; 4 ALLYL 2 METHOXYPHENYL NICOTINATE; ARACHIDONATE 15 LIPOXYGENASE; EUGENOL; IRON; LIGAND; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; LIPOPHILICITY; MOLECULAR MODEL;

AMINO ACIDS; ARACHIDONATE 15-LIPOXYGENASE; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EUGENOL; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SOYBEANS;

GLYCINE MAX;

EID: 38549098647     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.016     Document Type: Article

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