Synthesis and SAR studies of 3-allyl-4-prenyloxyaniline amides as potent 15-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5518-5526

  Jabbari, Atena ^a   Davoodnejad, Mahdieh ^b   Alimardani, Maliheh ^b   Assadieskandar, Amir ^c   Sadeghian, Ali ^d   Safdari, Hadi ^b   Movaffagh, Jebraeel ^b   Sadeghian, Hamid ^b,d  

^a FERDOWSI UNIVERSITY OF MASHHAD   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

DMAB; DPPH; MBTH; Radical scavenger; SLO

Indexed keywords

3 ALLYL 4 PRENYLOXYANILINE AMIDE; 3 ALLYL ALLYOXYANILINE AMIDE; 4 (3 METHYLBUT 2 ENYLOXY) 3 ALLYL N ADAMANTYLBENZENAMINE; 4 (3,7 DIMETHYLLOCTA 2,6 DIENYLOXY) 3 ALLYL N ADAMANTYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N ADAMANTYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N CYCLOBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N CYCLOBUTYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N CYCLOPENTYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N CYCLOPROPYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYL N METHYLBENZENAMINE; 4 (3,7,11 TRIMETHYLDODECA 2,6,10 TRIENYLOXY) 3 ALLYLPHENYLBENZENAMINE; ARACHIDONATE 15 LIPOXYGENASE; LIPOXYGENASE INHIBITOR; N [3 ALLYL 4 (ALLYLOXY)PHENYL]ACETAMIDE; N [3 ALLYL 4 (ALLYLOXY)PHENYL]ADAMANTANECARBOXAMIDE; N [3 ALLYL 4 (ALLYLOXY)PHENYL]CYCLOBUTANECARBOXAMIDE; N [3 ALLYL 4 (ALLYLOXY)PHENYL]CYCLOHEXANECARBOXAMIDE; N [3 ALLYL 4 (ALLYLOXY)PHENYL]CYCLOPANTANECARBOXAMIDE; N [3 ALLYL 4 (ALLYLOXY)PHENYL]CYCLOPROPANECARBOXAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; MOLECULAR INTERACTION; STRUCTURE ACTIVITY RELATION;

AMIDES; ANILINE COMPOUNDS; ARACHIDONATE 15-LIPOXYGENASE; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOXYGENASE INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SOYBEANS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; GLYCINE MAX; MAMMALIA;

EID: 84866252838     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.07.025     Document Type: Article

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