SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 24, 2012, Pages 7175-7183

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

(8) Sabbah, Dima A a Simms, Neka A a Wang, Wang a Dong, Yuxiang a Ezell, Edward L a Brattain, Michael G a Vennerstrom, Jonathan L a Zhong, Haizhen A b

a UNIVERSITY OF NEBRASKA MEDICAL CENTER (United States)

b UNIVERSITY OF NEBRASKA AT OMAHA (United States)

Author keywords

AKT phosphorylation; Apoptosis; Colon cancer; PI3K; Selectivity

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; N (2 FLUOROPHENYL) 8 FLUORO 4 HYDROXY 2 QUINOLONE 3 CARBOXAMIDE; N (3 FLUOROPHENYL) 7 FLUORO 4 HYDROXY 2 QUINOLONE 3 CARBOXAMIDE; N (4 FLUOROPHENYL) 6 FLUORO 4 HYDROXY 2 QUINOLONE 3 CARBOXAMIDE; N (4 METHOXYPHENYL) 4 HYDROXY 6 METHOXY 2 QUINOLONE 3 CARBOXAMIDE; N 4 TOLYL 4 HYDROXY 6 METHYL 2 QUINOLONE 3 CARBOXAMIDE; N BENZYL 2 HYDROXYQUINOLINE 3 CARBOXAMIDE; N BENZYL QUINOLINE 3 CARBOXAMIDE; N PHENYL 4 HYDROXY 1 METHYL 2 QUINOLONE 3 CARBOXAMIDE; N PHENYL 4 HYDROXY 2 QUINOLONE 3 CARBOXAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; COLON CANCER; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; HYDROGEN BOND; IMMUNOBLOTTING; MOLECULAR DOCKING; PROTEIN CLEAVAGE; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; MUTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870053134 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.09.059 Document Type: Article

Times cited : (33)

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