Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents

Cancer Research

Volumn 56, Issue 15, 1996, Pages 3404-3408

  Joseph, Ingrid B J K ^a   Vukanovic, Jasminka ^c   Isaacs, John T ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; ACIDIC FIBROBLAST GROWTH FACTOR; ANDROGEN; ANDROSTANOLONE; ANDROSTANOLONE PROPIONATE; ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; MATRIGEL; METHYLNITROSOUREA; ROQUINIMEX; TESTOSTERONE; TESTOSTERONE PROPIONATE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CARCINOMA IN SITU; CONTROLLED STUDY; DRUG BLOOD LEVEL; FEMALE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTATE CANCER; RAT; SEMINAL VESICLE DISEASE; SUBCUTANEOUS DRUG ADMINISTRATION; TUMOR VASCULARIZATION;

ANDROGENS; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; FEMALE; GENITAL NEOPLASMS, MALE; GROWTH SUBSTANCES; HYDROXYQUINOLINES; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; PROSTATIC NEOPLASMS; RATS; RATS, INBRED STRAINS; RATS, WISTAR; SEMINAL VESICLES; SENSITIVITY AND SPECIFICITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029680471     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Crawford, E. D., Eisenberger, M. A., McLeod, D. C., Spaulding, J., Benson, R., Door, F. A., Blumenstein, B. A., Davis, M. A., and Goodman, P. J. A control randomized trial of Leuprolide with and without flutamide in prostatic cancer. N. Eng. J. Med., 321: 419-424, 1989.
2. Carter, H. B., Piantodosi, S., and Isaacs, J. T. Clinical evidence for and implications of the multistep development of prostate cancer J. Urol., 143: 742-746, 1990.
3. Bostwick, D. G. Prostatic intraepithelial neoplasia (PIN): current concepts. J. Cell Biochem. Suppl., 16H: 10-19, 1992.
4. Berges, R. R., Vukanovic, J., Epstein, J. I., CarMichel, M., Cisek, L., Johnson, D. E., Veltri, R. W., Walsh, P. C., and Isaacs, J. T. Implication of cell kinetic changes during the progression of human prostatic cancer. Clin Cancer Res., 1: 473-480, 1995.
5. Sakr, W. A., Haas, G. P., Cassin, B. F., Pontes, J. E., and Crissman, J. D. The frequency of carcinoma and intraepithelial neoplasia of the prostate in young male patients. J. Urol., 150: 379-385, 1993.
6. Scardino, P. T., Weaver, R., and Hudson, M. A. Early detection of prostate cancer. Hum. Pathol., 23: 211-222, 1992.
7. Weidner, N., Carrol, P. R., Flax, J., Blumenfeld, W., and Folkman, J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol., 143: 401-409, 1993.
8. Bigler, S. A., Brawer, M. K., and Deering, R. E. Comparison of microscopic vascularity in benign and malignant prostatic tissue. Hum. Pathol., 24: 220-226, 1993.
9. Wakui, S., Furusato, M., Itoh, T., Sasaki, H., Akiyama, A., Kinoshita, I., Asano, K., Tokuda, T., Aizawa, S., and Ushigome, S. Tumour angiogenesis in prostatic carcinoma with and without bone marrow metastasis: a morphometric study. J. Pathol., 168: 257-262, 1992.
10. Furusato, M., Wakui, S., Sasaki, H., Ito, K., and Ushigome, S. Tumour angiogenesis in latent prostatic carcinoma Br. J. Cancer, 70: 1244-1246, 1994.
11. Folkman, J., Watson, K., Ingber, D., and Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (Lond.), 339: 58-61, 1989.
12. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease Nat. Med., 1: 27-31, 1995.
13. Ichikawa, T., Lamb, J. C., Christensson, P. J., Hartley-Asp, B., and Isaacs, J. T. The antitumor effects of the quinoline-3-carboxamide Linomide on Dunning R-3327 rat prostatic cancers Cancer Res., 52: 3022-3028, 1992.
14. Vukanovic, J., Passaniti, A., Hirata, T., Traystman, R. J., Hartley-Asp, B., and Isaacs, J. T. Antiangiogenic effects of the quinoline-3-carboxamide Linomide Cancer Res., 53: 1833-1837, 1993.
15. Vukanovic, J., and Isaacs, J. T. Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers. Cancer Res., 55: 1499-1504, 1995.
16. Vukanovic, J., Hartley-Asp, B., and Isaacs, J. T. Inhibition of tumor angiogenesis and the therapeutic ability of Linomide against rat prostatic cancers The Prostate, 26: 235-246, 1995.
17. Vukanovic, J. and Isaacs, J. T. Human prostatic cancer cells are sensitive to programmed (apoptotic) death induced by the antiangiogenic agent Linomide. Cancer Res., 55: 3517-3520, 1995.
18. Mantovani, A., Botazzi, B., Colotta, G., Sozzani, A., and Ricco, L. The origin and function of tumor-associated macrophages. Immunol. Today, 13: 265-270, 1992.
19. Polverini, P. J. Macrophage induced angiogenesis: a review. Cytokines, 1: 54-73, 1989.
20. Joseph, I. B. J. K., and Isaacs, J. T. The antiangiogenic agent, Linomide inhibits TNF-α secretion via inhibition of its synthesis. The Prostate, in press, 1996.
21. Pollard, M., and Luckert, P. H. Autochthonous prostate adenocarcinomas in Lobund-Wistar rats: a model system. The Prostate, 11: 219-227, 1987.
22. Kyprianou, N., and Isaacs, J. T. Quantal relationship between prostatic dihydrotestosterone and prostatic cell content: critical threshold concept. The Prostate, 11: 41-50, 1987.
23. Slayter, M. V., Anzano, M. A., Kadomatsu, K., Smith, J. M., and Sporn, M. B. Histogenesis of induced prostate and seminal vesicle carcinoma in Lobund-Wistar rats: a system for histological scoring and grading. Cancer Res., 54: 1440-1445, 1994.
24. Isaacs, J. T. A mammary cancer suppressor gene and its site of action in the rat. Cancer Res., 51: 1591-1595, 1991.
25. Pollard, M., Luckert, P. H., and Snyder, D. Prevention and treatment of experimental prostate cancer in Lobund-Wistar rats I. Effects of estradiol, dihydrotestosterone, and castration. The Prostate, 15: 95-103, 1989.
26. Folkman, J., and Long, D. The use of silicone rubber as a carrier for prolonged drug therapy. J. Sur. Res. 4: 139-144, 1964.
27. Isaacs, J. T. Determination of the number of events required for mammary carcinogenesis in the Sprague-Dawley female rat Cancer Res., 45: 4827-4832, 1985.