Src homology 2 domain-containing phosphatase 2 (Shp2) is a component of the A-kinase-anchoring protein (AKAP)-Lbc complex and is inhibited by protein kinase A (PKA) under pathological hypertrophic conditions in the heart

Journal of Biological Chemistry

Volumn 287, Issue 48, 2012, Pages 40535-40546

  Burmeister, Brian T ^a   Taglieri, Domenico M ^a   Wang, Li ^a   Carnegie, Graeme K ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A-KINASE-ANCHORING PROTEINS; CARDIAC HYPERTROPHY; CARDIAC MASS; CARDIAC MYOCYTES; CONGENITAL HEART DEFECTS; HEART FAILURE; MAJOR FACTORS; PROTEIN KINASE A; PROTEIN-TYROSINE PHOSPHATASE; SRC HOMOLOGY 2; STRESS-INDUCED; TYROSINE PHOSPHATASE;

AMINO ACIDS; PATHOLOGY; PHOSPHATASES; PHOSPHORYLATION; PROTEINS;

HEART;

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN 137; PROTEIN TYROSINE PHOSPHATASE SHP 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART VENTRICLE HYPERTROPHY; HUMAN; HUMAN CELL; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

A KINASE ANCHOR PROTEINS; ANIMALS; CARDIOMEGALY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MALE; MICE; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTO-ONCOGENE PROTEINS;

EID: 84870044881     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.385641     Document Type: Article

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