Optimization of a refolding step for a therapeutic fusion protein in the quality by design (QbD) paradigm

Journal of Separation Science

Volumn 35, Issue 22, 2012, Pages 3160-3169

  Bade, Pratap D ^a   Kotu, Susmitha P ^a   Rathore, Anurag S ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

Design of Experiment; Design space; Granulocyte colony stimulating factor; Quality by design; Refolding

Indexed keywords

DESIGN SPACES; EXPERIMENTAL EXAMINATION; FIRST ORDER; FRACTIONAL FACTORIALS; FULL FACTORIAL DESIGN; FUSION PROTEINS; GRANULOCYTE-COLONY STIMULATING FACTOR; INCLUSION BODIES; NATIVE STRUCTURES; OPTIMAL CONDITIONS; PRIMARY OBJECTIVE; PROCESS PARAMETERS; PRODUCT QUALITY; PROTEIN CONCENTRATIONS; PROTEIN EXPRESSIONS; PROTEIN REFOLDING; QUALITY BY DESIGNS; REFOLDING; REFOLDING PROCESS; ROADMAP; SCREENING DESIGN; THREE PARAMETERS;

BIOTECHNOLOGY; DESIGN OF EXPERIMENTS; ESCHERICHIA COLI; OPTIMIZATION; PROTEINS; RATE CONSTANTS;

DESIGN;

GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN;

ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PRIORITY JOURNAL; PROTEIN REFOLDING; REACTION OPTIMIZATION;

BIOCHEMISTRY; ESCHERICHIA COLI; GRANULOCYTE COLONY-STIMULATING FACTOR; KINETICS; PROTEIN REFOLDING; RECOMBINANT FUSION PROTEINS;

ESCHERICHIA COLI;

EID: 84870044856     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.201200476     Document Type: Article

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