Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection

Journal of Medicinal Chemistry

Volumn 55, Issue 22, 2012, Pages 9900-9913

  Sánchez Moreno, Manuel ^a   Gómez Contreras, Fernando ^b   Navarro, Pilar ^c   Marín, Clotilde ^a   Olmo, Francisco ^a   Yunta, María J R ^b   Sanz, Ana María ^b   Rosales, María José ^a   Cano, Carmen ^b   Campayo, Lucrecia ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (IMIDAZOL 4 YL)ETHYLAMINO] 4 CHLOROPHTHALAZINE; 1 [3 (IMIDAZOL 1 YL)PROPYLAMINO] 4 CHLOROPHTHALAZINE; 1,4 BIS[2 (IMIDAZOL 4 YL)ETHYLAMINO]PHTHALAZINE; 1,4 BIS[3 (IMIDAZOL 1 YL)PROPYLAMINO]PHTHALAZINE; BENZNIDAZOLE; IMIDAZOLE; IRON SUPEROXIDE DISMUTASE; PHTHALAZINE DERIVATIVE; PYRUVIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GLUCOSE METABOLISM; HYDROGEN BOND; IMMUNE DEFICIENCY; MOLECULAR MODEL; MOUSE; NONHUMAN; TRYPANOSOMA CRUZI; VERO CELL;

ANIMALS; CELL DEATH; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMIDAZOLES; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITEMIA; PHTHALAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 84870036919     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3011004     Document Type: Article

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