In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum

International Journal of Antimicrobial Agents

Volumn 25, Issue 2, 2005, Pages 136-141

  González, Patricia ^a   Marín, Clotilde ^a   Rodríguez González, Isabel ^a   Hitos, Ana B ^a   Rosales, Maria Jose ^a   Reina, Matías ^b   Díaz, Jesús G ^c   González Coloma, Azucena ^d   Sánchez Moreno, Manuel ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

^d INSTITUTO DE CIENCIAS AGRARIAS   (Spain)

Author keywords

Anti leishmanials; In vitro; Leishmania infantum; Norditerpenoid alkaloids

Indexed keywords

15,22 O DIACETYL 19 OXODIHYDROATISINE; ALKALOID DERIVATIVE; AZITINE; ISOAZITINE; PENTAMIDINE ISETHIONATE; UNCLASSIFIED DRUG; ALKALOID; ANTIPROTOZOAL AGENT; DITERPENE;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; FEMALE; HOST CELL; IC 50; IN VITRO STUDY; LEISHMANIA INFANTUM; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; RAT; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG SENSITIVITY; GROWTH, DEVELOPMENT AND AGING; HUMAN; MACROPHAGE; MOUSE; PARASITOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; VISCERAL LEISHMANIASIS;

ALKALOIDS; ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; DITERPENES; FEMALE; HUMANS; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MACROPHAGES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; PARASITIC SENSITIVITY TESTS; RATS;

EID: 12344325870     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2004.08.010     Document Type: Article

References (16)

1. WHO Control of the Leishmaniases. Report of a WHO Expert Committee, Technical Report Series 793. Geneva; 1990.
2. O. Kayser, A.F. Kiderlen, and S.L. Croft Antileishmanial activity of two γ-pyrones from Podolepsis hieracioides (Asteraceae) Acta Trop 86 2003 105 107
3. O. Kayser, A.F. Kinderlen, and U. Folkens Antileishmanial activity of aurones Planta Med 65 1999 316 319
4. I. Berger, CM. Passreiter, and A. Cáceres Antiprotozoal activity of Neurolaena lobata Phytother Res 15 2001 327 330
5. M. Atta-ur-Rahman, and M.I. Choudary Diterpenoid and steroidal alkaloids Nat Prod Rep 16 1999 619 635
6. K.E. Panter, G.D. Manners, and B.L. Steigelmeier Larkspur poisoning: toxicology and alkaloid structure-activity relationships Biochem Syst Ecol 30 2002 113 128
7. 3H] noradrenaline uptake of the aconitum alkaloids aconitine, 3-acetylaconitine, lappaconitine, and N-desacetylla-ppaconitine in rat hippocampus Biochem Pharmacol 55 1998 883 888
8. K.R. Jennings, D.G. Brown, and D.P.J. Wright Methyllycaconitine, a naturally occuring insecticide with a high affinity for the insect cholinergic receptor Experientia 42 1986 611 613
9. A. Ulubelen, A. Mericli, and N. Kilincer Insect repellent activity of diterpenoid alkaloids Phytother Res 15 2001 170 171
10. A. González-Coloma, M. Reina, and A. Guadaño Structural diversity and defensive properties of norditerpenoid alkaloids J Chem Ecol 30 2004 1393 1408
11. I.A. Bessonova, and Sh.A. Shaidkhodzaeva Hetisane-type diterpene alkaloids Chem Nat Comp 36 2000 419 477
12. A. González-Coloma, A. Guadaño, and C. Gutiérrez Antifeedant Delphinium diterpene alkaloids. Structure-activity relationships Agric Food Chem 46 1998 286 290
13. L. Li, Y-M. Shen, and X-S. Yang Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica Eur J Pharmacol 449 2002 23 28
14. L. Li, Y.-M. Shen, and X.-S. Yang Effects of spiramine T on antioxidant enzymatic activities and nitric oxide production in cerebral ischemia-reperfusion gerbils Brain Res 944 2002 205 209
15. 20 Diterpene Alkaloids Chem Biodivers 1 2004 1327 1335
16. F. Luque, C. Fernández-Ramos, and E. Entrala In vitro evaluation of newly synthesised [1,2,4] triazolo [1,5a] pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli Comp Biochem Phys C 126 2000 39 44