Efficient inhibition of iron superoxide dismutase and of Trypanosoma cruzi growth by benzo[g]phthalazine derivatives functionalized with one or two imidazole rings

Journal of Medicinal Chemistry

Volumn 51, Issue 6, 2008, Pages 1962-1966

  Sanz, Ana M ^a   Gómez Contreras, Fernando ^a   Navarro, Pilar ^b   Sánchez Moreno, Manuel ^c   Boutaleb Charki, Samira ^c   Campuzano, Jose ^a   Pardo, Mercedes ^a   Osuna, Antonio ^c   Cano, Carmen ^a   Yunta, María J R ^a   Campayo, Lucrecia ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (IMIDAZOL 4 YL)ETHYLAMINO] 4 CHLOROBENZO[G]PHTHALAZINE; 1 [3 (IMIDAZOL 1 YL)PROPYLAMINO] 4 CHLOROBENZO[G]PHTHALAZINE; 1,4 BIS[2 (IMIDAZOL 4 YL)ETHYLAMINO]BENZO[G]PHTHALAZINE; 1,4 BIS[3 (IMIDAZOL 1 YL)PROPYLAMINO]BENZO[G]PHTHALAZINE; BENZNIDAZOLE; COPPER ZINC SUPEROXIDE DISMUTASE; IMIDAZOLE; IRON SUPEROXIDE DISMUTASE; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EPIMASTIGOTE; HUMAN; HUMAN CELL; NONHUMAN; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPARASITIC AGENTS; CERCOPITHECUS AETHIOPS; HUMANS; IMIDAZOLES; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PHTHALAZINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDE DISMUTASE; TRYPANOSOMA CRUZI; VERO CELLS;

EID: 41149089245     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm701179m     Document Type: Article

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