Imidazo[1,2-a]pyridines: Orally active positive allosteric modulators of the metabotropic glutamate 2 receptor

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2688-2701

  Trabanco, Andrés A ^a   Tresadern, Gary ^a   MacDonald, Gregor J ^a   Vega, Juan Antonio ^a   De Lucas, Ana Isabel ^a   Matesanz, Encarnación ^a   García, Aránzazu ^a   Linares, María Lourdes ^a   Alonso De Diego, Sergio A ^a   Alonso, José Manuel ^a   Oehlrich, Daniel ^a   Ahnaou, Abdelah ^a   Drinkenburg, Wilhelmus ^a   MacKie, Claire ^a   Andrés, José Ignacio ^a   Lavreysen, Hilde ^a   Cid, José María ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLORO 7 (7 CHLORO 1H INDOL 5 YL) 3 (2,2,2 TRIFLUOROETHYL) IMIDAZO[1,2 A]PYRIDINE; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; METABOTROPIC RECEPTOR 2; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ALLOSTERIC REGULATION; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BIOLOGICAL AVAILABILITY; BRAIN; CELL LINE; CRICETINAE; CRICETULUS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; IMIDAZOLES; INDOLES; ION CHANNELS; MALE; MICE; MICROSOMES, LIVER; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP; WAKEFULNESS;

EID: 84858735001     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201561r     Document Type: Article

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