SCOPUS 정보 검색 플랫폼

Volumn 3, Issue 12, 2012, Pages 1518-1525

A matched molecular pair analysis of in vitro human microsomal metabolic stability measurements for methylene substitution or replacements - Identification of those transforms more likely to have beneficial effects

(1) Dossetter, Alexander G a

a ASTRAZENECA (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; METABOTROPIC RECEPTOR 5; NITROGEN; OXYGEN; SULFUR;

ANALYTIC METHOD; ARTICLE; BIOCHEMISTRY; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG METABOLISM; DRUG STABILITY; ENANTIOMER; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LIPOPHILICITY; MATCHED MOLECULAR PAIR ANALYSIS; MICROSOME MEMBRANE; MOLECULAR STABILITY; OXIDATION; PRIORITY JOURNAL; PROBABILITY; PROCESS OPTIMIZATION;

EID: 84870018107 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c2md20226c Document Type: Article

Times cited : (13)

References (23)

1
- 0028132823
- N. H. Cnubben S. Peelen J. W. Borst J. Vervoort C. Veeger I. M. Rietjens Chem. Res. Toxicol. 1994 7 590 598
- (1994) Chem. Res. Toxicol. , vol.7 , pp. 590-598
- Cnubben, N.H.¹ Peelen, S.² Borst, J.W.³ Vervoort, J.⁴ Veeger, C.⁵ Rietjens, I.M.⁶

2
- 0026459382
- 10.1016/0006-2952(92)90333-E
- D. A. Smith B. C. Jones Biochem. Pharmacol. 1992 44 2089 2098 10.1016/0006-2952(92)90333-E
- (1992) Biochem. Pharmacol. , vol.44 , pp. 2089-2098
- Smith, D.A.¹ Jones, B.C.²

3
- 84870037085
- US Pat. 6,211,244
- B. C. Van Wagenen, S. T. Moe, M. F. Balandrin, E. G. Delmar and E. F. Nemeth, US Pat. 6,211,244, 2001
- (2001)
- Van Wagenen, B.C.¹ Moe, S.T.² Balandrin, M.F.³ Delmar, E.G.⁴ Nemeth, E.F.⁵

4
- 71049126548
- 10.1021/jm901241e
- F. Lovering J. Bikker C. Humblet J. Med. Chem. 2009 52 6752 6756 10.1021/jm901241e
- (2009) J. Med. Chem. , vol.52 , pp. 6752-6756
- Lovering, F.¹ Bikker, J.² Humblet, C.³

5
- 41149161847
- M. Rowley Prog. Med. Chem. 2008 46 1 28
- (2008) Prog. Med. Chem. , vol.46 , pp. 1-28
- Rowley, M.¹

6
- 34247611806
- 10.1021/jm070027u
- P. Pace M. E. Di Francesco C. Gardelli S. Harper E. Muraglia E. Nizi F. Orvieto A. Petrocchi M. Poma M. Rowley R. Scarpelli R. Laufer O. Gonzalez Paz E. Monteagudo F. Bonelli D. Hazuda K. A. Stillmock V. Summa J. Med. Chem. 2007 50 2225 2239 10.1021/jm070027u
- (2007) J. Med. Chem. , vol.50 , pp. 2225-2239
- Pace, P.¹ Di Francesco, M.E.² Gardelli, C.³ Harper, S.⁴ Muraglia, E.⁵ Nizi, E.⁶ Orvieto, F.⁷ Petrocchi, A.⁸ Poma, M.⁹ Rowley, M.¹⁰ Scarpelli, R.¹¹ Laufer, R.¹² Gonzalez Paz, O.¹³ Monteagudo, E.¹⁴ Bonelli, F.¹⁵ Hazuda, D.¹⁶ Stillmock, K.A.¹⁷ Summa, V.¹⁸

7
- 0025334928
- 10.1002/hlca.19900730323
- R. Amstutz A. Enz M. Marzi J. Boelsterli M. Walkinshaw Helv. Chim. Acta 1990 73 739 753 10.1002/hlca.19900730323
- (1990) Helv. Chim. Acta , vol.73 , pp. 739-753
- Amstutz, R.¹ Enz, A.² Marzi, M.³ Boelsterli, J.⁴ Walkinshaw, M.⁵

8
- 2642517752
- 10.1358/dof.2004.029.04.793861
- L. A. Sorbera J. Castaner N. E. Mealy Drugs Future 2004 29 336 341 10.1358/dof.2004.029.04.793861
- (2004) Drugs Future , vol.29 , pp. 336-341
- Sorbera, L.A.¹ Castaner, J.² Mealy, N.E.³

9
- 49449097238
- 10.1021/jm800219f
- W. K. Hagmann J. Med. Chem. 2008 51 4359 4369 10.1021/jm800219f
- (2008) J. Med. Chem. , vol.51 , pp. 4359-4369
- Hagmann, W.K.¹

10
- 77953137063
- A. G. Dossetter Bioorg. Med. Chem. 2010 18 4405 4414
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 4405-4414
- Dossetter, A.G.¹

11
- 68149129503
- 10.1016/j.bmc.2009.07.002
- P. Gleeson G. Bravi S. Modi D. Lowe Bioorg. Med. Chem. 2009 17 5906 5919 10.1016/j.bmc.2009.07.002
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 5906-5919
- Gleeson, P.¹ Bravi, G.² Modi, S.³ Lowe, D.⁴

12
- 58149343803
- 10.1007/s10822-008-9242-3
- M. L. Lewis L. Cucurull-Sanchez J. Comput.-Aided Mol. Des. 2009 23 97 103 10.1007/s10822-008-9242-3
- (2009) J. Comput.-Aided Mol. Des. , vol.23 , pp. 97-103
- Lewis, M.L.¹ Cucurull-Sanchez, L.²

13
- 39149090377
- 10.1021/jm070838y
- P. J. Hajduk D. R. Sauer J. Med. Chem. 2008 51 553 564 10.1021/jm070838y
- (2008) J. Med. Chem. , vol.51 , pp. 553-564
- Hajduk, P.J.¹ Sauer, D.R.²

14
- 33750976700
- 10.1021/jm0605233
- A. G. Leach H. D. Jones D. A. Cosgrove P. W. Kenny L. Ruston P. MacFaul J. M. Wood N. Colclough B. Law J. Med. Chem. 2006 49 6672 6682 10.1021/jm0605233
- (2006) J. Med. Chem. , vol.49 , pp. 6672-6682
- Leach, A.G.¹ Jones, H.D.² Cosgrove, D.A.³ Kenny, P.W.⁴ Ruston, L.⁵ MacFaul, P.⁶ Wood, J.M.⁷ Colclough, N.⁸ Law, B.⁹

15
- 0036025428
- 10.1021/ci0100806
- R. P. Sheridan J. Chem. Inf. Comput. Sci. 2002 42 103 108 10.1021/ci0100806
- (2002) J. Chem. Inf. Comput. Sci. , vol.42 , pp. 103-108
- Sheridan, R.P.¹

16
- 81555204763
- 10.1021/jm200452d
- E. Griffen A. G. Leach G. R. Robb D. J. Warner J. Med. Chem. 2011 54 7739 7750 10.1021/jm200452d
- (2011) J. Med. Chem. , vol.54 , pp. 7739-7750
- Griffen, E.¹ Leach, A.G.² Robb, G.R.³ Warner, D.J.⁴

17
- 0000898845
- S. S. Shapiro M. B. Wilk Biometrika 1965 52 591 611
- (1965) Biometrika , vol.52 , pp. 591-611
- Shapiro, S.S.¹ Wilk, M.B.²

18
- 12344293138
- C. W. Dunnett R. Crisafio J. Pharm. Pharmacol. 1955 7 314 327
- (1955) J. Pharm. Pharmacol. , vol.7 , pp. 314-327
- Dunnett, C.W.¹ Crisafio, R.²

19
- 84860456763
- A. G. Leach E. A. Pilling A. A. Rabow S. Tomasi N. Asaad N. J. Buurma A. Ballard S. Narduolo Med. Chem. Commun. 2012 3 528 540
- (2012) Med. Chem. Commun. , vol.3 , pp. 528-540
- Leach, A.G.¹ Pilling, E.A.² Rabow, A.A.³ Tomasi, S.⁴ Asaad, N.⁵ Buurma, N.J.⁶ Ballard, A.⁷ Narduolo, S.⁸

20
- 0035438391
- 10.1021/ci010366a
- T. I. Oprea A. M. Davis S. J. Teague P. D. Leeson J. Chem. Inf. Comput. Sci. 2001 41 1308 1315 10.1021/ci010366a
- (2001) J. Chem. Inf. Comput. Sci. , vol.41 , pp. 1308-1315
- Oprea, T.I.¹ Davis, A.M.² Teague, S.J.³ Leeson, P.D.⁴

21
- 44849117524
- D. Pagé E. Balaux L. Boisvert Z. Liu C. Milburn M. Tremblay Z. Wei S. Woo X. Luo Y. Cheng H. Yang S. Srivastava F. Zhou W. Brown M. Tomaszewski C. Walpole L. Hodzic S. St-Onge C. Godbout D. Salois K. Payza Bioorg. Med. Chem. Lett. 2008 18 3695 3700
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 3695-3700
- Pagé, D.¹ Balaux, E.² Boisvert, L.³ Liu, Z.⁴ Milburn, C.⁵ Tremblay, M.⁶ Wei, Z.⁷ Woo, S.⁸ Luo, X.⁹ Cheng, Y.¹⁰ Yang, H.¹¹ Srivastava, S.¹² Zhou, F.¹³ Brown, W.¹⁴ Tomaszewski, M.¹⁵ Walpole, C.¹⁶ Hodzic, L.¹⁷ St-Onge, S.¹⁸ Godbout, C.¹⁹ Salois, D.²⁰ Payza, K.²¹ more..

22
- 84870037086
- US20050272779A1
- L. Edwards, M. Isaac, M. Johansson, A. Kers, J. Malmberg, D. McLeod, A. Mindis, K. Staaf, A. Slassi, T. Stefanac, T. Stormann, D. Wensbo, T. Xin and J. Arora, US20050272779A1, (2005)
- (2005)
- Edwards, L.¹ Isaac, M.² Johansson, M.³ Kers, A.⁴ Malmberg, J.⁵ McLeod, D.⁶ Mindis, A.⁷ Staaf, K.⁸ Slassi, A.⁹ Stefanac, T.¹⁰ Stormann, T.¹¹ Wensbo, D.¹² Xin, T.¹³ Arora, J.¹⁴

23
- 84869999485
- WO2009019506A1
- E. Hennessy, D. Li, V. Oza, G. Grewal and J. C. Saeh, WO2009019506A1, (2009)
- (2009)
- Hennessy, E.¹ Li, D.² Oza, V.³ Grewal, G.⁴ Saeh, J.C.⁵

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.