MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients

JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

Volumn 13, Issue 4, 2012, Pages 472-477

  El Baz, Rizk ^a   Settin, Ahmad ^a   Ismaeel, Azza ^b   Khaleel, Abd Allah ^c   Abbas, Tarek ^c   Tolba, Wafaa ^b   Abd Allah, Wafaa ^b   Sobh, Mohammed Abd El Kader ^c  

^a MANSOURA UNIVERSITY   (Egypt)

^b Mansoura University   (Egypt)

^c MANSOURA UNIVERSITY   (Egypt)

Author keywords

ACE gene; diabetic nephropathy; MTHFR gene; polymorphism; type 2 diabetes

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; ALBUMINURIA; ARTICLE; DIABETIC NEPHROPATHY; DIABETIC PATIENT; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK FACTOR;

ALBUMINURIA; ALLELES; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INDEL MUTATION; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84869989657     PISSN: 14703203     EISSN: 17528976     Source Type: Journal    
DOI: 10.1177/1470320312444651     Document Type: Article

References (60)

1. Sun J, Xu Y, Zhu Y, et al. Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Res Clin Pract. 2004 ; 64: 185-190
2. Rossing P. Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history. Curr Diab Rep. 2006 ; 6: 479-483
3. Zintzaras E, Uhlig K, Koukoulis GN, et al. Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: A meta-analysis. J Hum Genet. 2007 ; 52: 881-890
4. Eroglu Z, Cetinkalp S, Erdogan M, et al. Association of the angiotensinogen M235T and angiotensin-converting enzyme insertion/deletion gene polymorphisms in Turkish type 2 diabetic patients with and without nephropathy. J Diabetes Complications. 2008 ; 22: 186-190
5. Ahluwalia TS, Ahuja M, Rai TS, et al. ACE variants interact with the RAS pathway to confer risk and protection against type 2 diabetic nephropathy. DNA Cell Biol. 2009 ; 28: 141-150
6. Jayapalan JJ, Muniandy S, Chan SP. Null association between ACE gene I/D polymorphism and diabetic nephropathy among multiethnic Malaysian subjects. Indian J Hum Genet. 2010 ; 16: 78-86
7. Petrovic D, Zorc M, Kanic V, et al. Interaction between gene polymorphisms of renin-angiotensin system and metabolic risk factors in premature myocardial infarction. Angiology. 2001 ; 52: 247-252
8. Ranjith N, Pegoraro RJ, Rom L, et al. Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians. Cardiovasc J S Afr. 2004 ; 15: 22-26
9. Danser AH, Schalekamp MA, Bax WA, et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 1995 ; 92: 1387-1388
10. Möllsten A, Kockum I, Svensson M, et al. The effect of polymorphisms in the renin-angiotensin-aldosterone system on diabetic nephropathy risk. J Diabetes Complications. 2008 ; 22: 377-383
11. Tikellis C, Johnston CI, Forbes JM, et al. Characterization of renal angiotensin- converting enzyme 2 in diabetic nephropathy. Hypertension. 2003 ; 41: 392-397
12. Ortega-Pierres LE, Gómez García A, Rodríguez-Ayala E, et al. Angiotensin 1 converting enzyme insertion/deletion gene polymorphism in a Mexican population with diabetic nephropathy. Med Clin (Barc). 2007 ; 129: 6-10
13. Födinger M, Hörl WH, Sunder-Plassmann G. Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol. 2000 ; 13: 20-33
14. Parvanova A, Iliev I, Dimitrov BD, et al. Hyperhomocysteinemia and increased risk of retinopathy: A cross-sectional, case-control study in patients with type 2 diabetes. Diabetes Care. 2002 ; 25: 2361
15. Mtiraoui N, Ezzidi I, Chaieb M, et al. MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2007 ; 75: 99-106
16. Donnelly JG. Folic acid. Crit Rev Clin Lab Sci. 2001 ; 38: 183-223
17. Toffoli G, De Mattia E. Pharmacogenetic relevance of MTHFR polymorphisms. Pharmacogenomics. 2008 ; 9: 1195-1206
18. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Geneva: World Health Organization ; 2006 :
19. Ovbiagele B. Microalbuminuria: Risk factor and potential therapeutic target for stroke?. J Neurol Sci. 2008 ; 271: 21-28
20. Lindpaintner K, Pfeffer MA, Kreutz R, et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med. 1995 ; 332: 706-711
21. Siemianowicz K, Gminski J, Garczorz W, et al. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer. Oncol Rep. 2003 ; 10: 1341-1344
22. Tanaka N, Babazono T. Assessing genetic susceptibility to diabetic nephropathy. Nephrology (Carlton). 2005 ; 10: S17 - S21
23. Ukinc K, Ersoz HO, Karahan C, et al. Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy. Endocrine. 2009 ; 36: 255-261
24. Hu S, Gan P, Li J, et al. The relationship between the mutation of methylenetetrahydrofolate reductase gene 677C->T and the diabetic microangiopathy. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 ; 18: 118-121
25. Sun J, Xu Y, Zhu Y. The association of methylenetetrahydrofolate reductase gene polymorphism with nephropathy in type 2 diabetes mellitus in Chinese. Zhonghua Nei Ke Za Zhi. 2001 ; 40: 529-532
26. Wang L, Wang J, Xue Y, et al. Relationship between methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001 ; 18: 276-278
27. Ksiazek P, Bednarek-Skublewska A, Buraczyńska M. The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus. Med Sci Monit. 2004 ; 10: BR47 - BR51
28. Rahimi M, Hasanvand A, Rahimi Z, et al. Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus. Clin Biochem. 2010 ; 43: 1333-1339
29. Neugebauer S, Baba T, Watanabe T. Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients. Lancet. 1998 ; 352: 454
30. Fujisawa T, Ikegami H, Kawaguchi Y, et al. Meta analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy. Diabetologia. 1998 ; 41: 47-53
31. Ng DP, Tai BC, Koh D, et al. Angiotensin-I converting enzyme insertion/deletion polymorphism and its association with diabetic nephropathy: A meta analysis of studies reported between 1994 and 2004 and comprising 14,727 subjects. Diabetologia. 2005 ; 48: 1008-1016
32. Movva S, Alluri RV, Komandur S, et al. Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with type 2 diabetes mellitus in Asian Indians. J Diabetes Complications. 2007 ; 21: 237-241
33. Viswanathan V. Prevention of diabetic nephropathy: A diabetologist's perspective. Indian J Nephrol. 2004 ; 14: 157-162
34. Naresh VV, Reddy AL, Sivaramakrishna G, et al. Angiotensin converting enzyme gene polymorphism in type II diabetics with nephropathy. Indian J Nephrol. 2009 ; 19: 145-148
35. Tarnow L, Gluud C, Parving HH. Diabetic nephropathy and the insertion/deletion polymorphism of the angiotensin-converting enzyme gene. Nephrol Dial Transplant. 1998 ; 13: 1125-1130
36. Kunz R, Bork JP, Fritsche L, et al. Association between the angiotensin-converting enzyme insertion/deletion polymorphism and diabetic nephropathy: A methodologic appraisal and systematic review. J Am Soc Nephrol. 1998 ; 9: 1653-1663
37. Hadjadj S, Belloum R, Bouhanick B, et al. Prognostic value of angiotensin I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: A prospective study. J Am Soc Nephrol. 2001 ; 12: 541-549
38. Uddin M, Azam M, Chowdhury N, et al. AngiotensinI-converting enzyme gene polymorphism in type 2 diabetic patients with nephropathy. J Med Sci. 2007 ; 7: 682-685
39. Jacobsen P, Rossing K, Rossing P, et al. Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy. Kidney Int. 1998 ; 53: 1002-1006
40. Parving HH, Jacobsen P, Tarnow L, et al. Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: Observational follow up study. BMJ. 1996 ; 313: 591-594
41. Perna A, Ruggenenti P, Testa A, et al. ACE genotype and ACE inhibitors induced renoprotection in chronic proteinuric nephropathies. Kidney Int. 2000 ; 57: 274-281
42. Fujita H, Narita T, Meguro H, et al. No association between MTHFR gene polymorphism and diabetic nephropathy in Japanese type II diabetic patients with proliferative diabetic retinopathy. J Diabetes Complications. 1999 ; 13: 284-287
43. Odawara M, Yamashita K, Yamada N. MTHFR gene variant is not associated with diabetic nephropathy in Japanese. Nucleic Acids Symp Ser. 1999 ; 42: 85-86
44. Yoshioka K, Yoshida T, Umekawa T, Kogure A, et al. Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese Type 2 diabetic patients. Diabet Med. 2004 ; 21: 1051-1052
45. Maeda M, Yamamoto I, Fukuda M, et al. MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients. J Diabetes Complications. 2008 ; 22: 119-125
46. Eroglu Z, Erdogan M, Tetik A, et al. The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy. Diabetes Metab Res Rev. 2007 ; 23: 621-624
47. Blüthner M, Brüntgens A, Schmidt S, et al. Association of methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy in type 2 diabetes?. Nephrol Dial Transplant. 1999 ; 14: 56-57
48. Moczulski D, Fojcik H, Zukowska-Szczechowska E, et al. Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy. Nephrol Dial Transplant. 2003 ; 18: 1535-1540
49. Shin JS, Oh KS, Kwon SK, et al. MTHFR gene polymorphism as a risk factor for diabetic nephropathy and macrovascular disease in NIDDM patient. Korean J Med. 2001 ; 61: 391-398
50. Shpichinetsky V, Raz I, Friedlander Y, et al. The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients. J Nutr. 2000 ; 130: 2493-2497
51. Wong TY, Chan JC, Poon E, et al. Lack of association of angiotensin-converting enzyme (DD/II) and angiotensinogen M235Tgene polymorphism with renal function among Chinese patients with type II diabetes. Am J Kidney Dis. 1999 ; 33: 1064-1070
52. Schmidt S, Schöne N, Ritz E. Association of ACE gene polymorphism and diabetic nephropathy? The Diabetic Nephropathy Study Group. Kidney Int. 1995 ; 47: 1176-1181
53. Pfohl M, Frost D, Koch M, et al. Lack of association between the insertion/deletion polymorphism of the angiotensin-converting-enzyme gene and diabetic nephropathy in IDDM patients. Horm Metab Res. 1998 ; 30: 276-280
54. Tarnow L, Cambien F, Rossing P, et al. Lack of relationship between an insertion/deletion polymorphism in the angiotensin I-converting enzyme gene and diabetic nephropathy and proliferative retinopathy in IDDM patients. Diabetes. 1995 ; 44: 489-494
55. Arzu Ergen H, Hatemi H, Agachan B, et al. Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients. Exp Mol Med. 2004 ; 36: 345-350
56. Degirmenci I, Kebapci N, Basaran A, et al. Frequency of angiotensin-converting enzyme gene polymorphism in Turkish type 2 diabetic patients. Int J Clin Pract. 2005 ; 59: 1137-1142
57. Shin Shin Y, Baek SH, Chang KY, et al. Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy. Diabetes Res Clin Pract. 2004 ; 65: 257-265
58. Rahimi Z, Felehgari V, Rahimi M, et al. The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria. Mol Biol Rep. 2011 ; 38: 2117-2123
59. Felehgari V, Rahimi Z, Mozafari H, et al. ACE gene polymorphism and serum ACE activity in Iranians type II diabetic patients with macroalbuminuria. Mol Cell Biochem. 2011 ; 346: 23-30
60. Van Ittersum FJ, de Man AM, Thijssen S, et al. Genetic polymorphisms of the renin-angiotensin system and complications of insulin-dependent diabetes mellitus. Nephrol Dial Transplant. 2000 ; 15: 1000-1007