ACE genotype and ACE inhibitors induced renoprotection in chronic proteinuric nephropathies

Kidney International

Volumn 57, Issue 1, 2000, Pages 274-281

  Perna, Annalisa ^a,b,c   Ruggenenti, Piero ^a,b,c   Testa, Alessandra ^a,b,c   Spoto, Belinda ^a,b,c   Benini, Roberto ^a,b,c   Misefari, Valerio ^a,b,c   Remuzzi, Giuseppe ^a,b,c   Zoccali, Carmine ^a,b,c  

^a MARIO NEGRI INST PHARMACOL RES   (Italy)

^b OSPEDALI RIUNITI   (Italy)

^c Ctr of C P of the C N delle R   (Italy)

Author keywords

Angiotensin converting enzyme; End stage renal disease; Genotype; Proteinuria; Ramipril

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; RAMIPRIL;

ACUTE KIDNEY FAILURE; ADULT; ARTICLE; CLINICAL TRIAL; DISEASE COURSE; DNA POLYMORPHISM; DRUG EFFICACY; DRUG RESPONSE; FEMALE; GENE DELETION; GENE INSERTION; GENOTYPE; GLOMERULUS FILTRATION RATE; HUMAN; INCIDENCE; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEINURIA;

EID: 0034053726     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00818.x     Document Type: Article

References (25)

1. 1. Remuzzi G, Bertani T: The pathophysiology of progressive nephropathies. N Engl J Med 339:1448-1456, 1998
2. 2. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD, The collaborative study group: The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. N Engl J Med 329:1456-1462, 1993
3. 3. The Gisen Group: Randomized placebo controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 349:1857-1863, 1997
4. 4. Ruggenenti P, Perna A, Gherardi G, Gaspari F, Benini R, Remuzzi G, Gruppo italiano di studi epidemiologici in nefrologia (GISEN): Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN followtrial. Lancet 352:1252-1256, 1998
5. 5. Ruggenenti P, Perna A, Gherardi G, Benini R, Remuzzi G, Gruppo italiano di studi epidemiologici in nefrologia (GISEN): Chronic proteinuric nephropathies. I. Outcomes and response to treatment in a prospective cohort of 352 patients with different patterns of renal injury. Am J Kidney Dis (submitted)
6. 6. Ruggenenti P, Perna A, Zoccali C, Gherardi G, Benini R, Remuzzi G, Gruppo italiano di studi epidemiologici in nefrologia (GISEN): Chronic proteinuric nephropathies. II. Outcomes and response to treatment in a prospective cohort of 352 patients: Differences between women and men. J Am Soc Nephrol (in press)
7. 7. Maschio G, Alberti D, Janin J, Locatelli F, Mann JFE, Motolese M, Ponticelli C, Ritz E, Zucchelli P, Angiotensin converting enzyme inhibition in progressive renal insufficiency study group: Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med 334:939-945, 1996
8. 8. Ruggenenti P, Perna A, Benini R, Bertani T, Zoccali C, Maggiore Q, Remuzzi G, Gruppo italiano di studi epidemiologici in nefrologia (GISEN): In chronic nephropathies prolonged ACE-inhibition can induce remission: Dynamics of time-dependent changes in GFR. J Am Soc Nephrol 10:997-1006, 1999
9. 9. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G, Gruppo italiano di studi epidemiologici in nefrologia (GISEN): Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. Kidney Int 53:1209-1216, 1998
10. 10. Schmidt S, Ritz E: Genetics of the renin-angiotensin system and renal disease: A progress report. Curr Opin Nephrol Hypertens 6:146-151, 1997
11. 11. Schmidt S, Ritz E: The role of angiotensin I-converting enzyme gene polymorphism in renal disease. Curr Opin Nephrol Hypertens 5:552-555, 1996
12. 12. Yoshida H, Kon V, Ichikawa I: Polymorphisms of the reninangiotensin system genes in progressive renal disease. (editorial) Kidney Int 50:732-744, 1996
13. 13. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346, 1990
14. 14. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F: Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene control plasma ACE levels. Am J Hum Genet 51:197-205, 1992
15. 15. Yoshida H, Mitarai T, Kawamura T, Kitajima T, Miyazaki Y, Nagasawa R, Kawaguchi Y, Kubo H, Ichikawa I, Sakai O: Role of the deletion polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. J Clin Invest 96:2162-2169, 1995
16. 16. Moriyama T, Kitamura H, Ochi S, Izumi M, Yokoyama K, Jamauchi A, Veda N, Kamada T, Imai E: Association of angiotensin I-converting enzyme gene polymorphism with susceptibility to antiproteinuric effect of angiotensin I-converting enzyme inhibitors in patients with proteinuria. J Am Soc Nephrol 6:1676-1678, 1995
17. 17. Gonzalo A, Telleria D, San Millan JL, Ortuno J: Angiotensin I-converting enzyme gene polymorphism and antiproteinuric response to renoprotective therapy. Nephrol Dial Transplant 13:1050-1051, 1998
18. 18. Van Essen G, Rensma PL, De Zeeuw D, Sluiter WJ, Scheffer H, Apperloo AJ: Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy. Lancet 347:94-95, 1996
19. 19. Van Der Kleij FGH, Navis GJ, Gansevoort RT, Heeg JE, Scheffer H, De Zeeuw D, De Jong PE: ACE polymorphism does not determine short-term renal response to ACE-inhibition in proteinuric patients. Nephrol Dial Transplant 12(Suppl 2):42-46, 1997
20. 20. Gruppo Italiano Studi Epidemiologici in Nefrologia (GISEN): A long-term, randomized clinical trial to evaluate the effects of ramipril on the evolution of renal function in chronic nephropathies. J Nephrol 3:193-202, 1991
21. 21. Gaspari F, Perico N, Ruggenenti P, Mosconi L, Amuchastegui CS, Guerini E, Daina E, Remuzzi G: Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate in patients with normal or impaired renal function. J Am Soc Nephrol 6:1-7, 1995
22. 22. Rice EW: Improved biuret procedure for determination of urinary total proteins in clinical proteinuria. Clin Chem 21:398-401, 1975
23. 23. Kendall KG, Stuart A: The advanced theory of statistics, in Inference and Relationship (3rd ed, vol 2), London, Griffin, 1973, pp 323-324
24. 24. Draper N, Smith H: Applied Regression Analysis (2nd ed). New York, J. Wiley and Sons Inc., 1981
25. 25. Cox DR: Regression models and life-tables (with discussion). J Royal Stat Soc (Series B) 34:187-220, 1972