Pharmacokinetic study of mucoadhesive metformin pellets in rats

Journal of Pharmaceutical Investigation

Volumn 42, Issue 3, 2012, Pages 133-137

  Piao, Jingshu ^a   Lee, Ji Eun ^a   Shin, Dae Hwan ^a   Kim, Jin Seok ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

Metformin hydrochloride; Mucoadhesive polymer coated pellet; Pharmacodynamics; Pharmacokinetics; Type II diabetes

Indexed keywords

ALGINIC ACID; CARBOMER; GELATIN; HYDROXYMETHYLCELLULOSE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG PELLET; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MUCOADHESION; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 84869883275     PISSN: 20935552     EISSN: 20936214     Source Type: Journal    
DOI: 10.1007/s40005-012-0019-2     Document Type: Article

References (20)

1. Adikwu MU, Yoshikawa Y, Takada K (2004) Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models. Biomaterials 25: 3041-3048.
2. Bailey CJ, Turner RC (1996) Metformin. N Engl J Med 334: 574-579.
3. Balasubramaniam J, Rao VU, Vasudha M, Babu J, Rajinikanth PS (2007) Sodium alginate microspheres of metformin HCl: formulation and in vitro evaluation. Curr Drug Deliv 4: 249-256.
4. Briede J, Stivrina M, Stoldere D, Vigante B, Duburs G (2007) Effect of cerebrocrast, a new long-acting compound on blood glucose and insulin levels in rats when administered before and after STZ-induced diabetes mellitus. Cell Biochem Funct 25: 673-680.
5. Cayley WE Jr (2002) Inappropriate prescription for metformin. JAMA 288: 694 (author reply 694-695).
6. Choi YH, Lee MG (2012) Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes. Xenobiotica 42: 483-495.
7. Dunn CJ, Peters DH (1995) Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs 49: 721-749.
8. El-Kamel A, Sokar M, Naggar V, Al Gamal S (2002) Chitosan and sodium alginate-based bioadhesive vaginal tablets. AAPS PharmSci 4: E44.
9. Graham GG, Punt J, Arora M, Day RO, Doogue MP, Duong JK, Furlong TJ, Greenfield JR, Greenup LC, Kirkpatrick CM, Ray JE, Timmins P, Williams KM (2011) Clinical pharmacokinetics of metformin. Clin Pharmacokinet 50: 81-98.
10. Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
11. Hu LD, Liu Y, Tang X, Zhang Q (2006) Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets. Eur J Pharm Biopharm 64: 185-192.
12. Kar M, Choudhury PK (2007) Formulation and evaluation of ethyl cellulose microspheres prepared by the multiple emulsion technique. Pharmazie 62: 122-125.
13. Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, Kim JK (2004) Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 53: 1060-1067.
14. Lee JS (2006) Effects of soy protein and genistein on blood glucose, antioxidant enzyme activities, and lipid profile in streptozotocin-induced diabetic rats. Life Sci 79: 1578-1584.
15. Mandal U, Gowda V, Ghosh A, Selvan S, Solomon S, Pal TK (2007) Formulation and optimization of sustained release matrix tablet of metformin HCl 500 mg using response surface methodology. Yakugaku Zasshi 127: 1281-1290.
16. Ofori-Kwakye K, Fell JT, Sharma HL, Smith AM (2004) Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release. Int J Pharm 270: 307-313.
17. Piao J, Lee JE, Weon KY, Kim DW, Lee JS, Park JD, Nishiyama Y, Fukui I, Kim JS (2009) Development of novel mucoadhesive pellets of metformin hydrochloride. Arch Pharm Res 32: 391-397.
18. Stepensky D, Friedman M, Srour W, Raz I, Hoffman A (2001) Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation. J Control Release 71: 107-115.
19. Stepensky D, Friedman M, Raz I, Hoffman A (2002) Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect. Drug Metab Dispos 30: 861-868.
20. Zarghi A, Foroutan SM, Shafaati A, Khoddam A (2003) Rapid determination of metformin in human plasma using ion-pair HPLC. J Pharm Biomed Anal 31: 197-200.