Preclinical evaluation of pharmacokinetic-pharmacodynamic rationale for oral CR metformin formulation

Journal of Controlled Release

Volumn 71, Issue 1, 2001, Pages 107-115

  Stepensky, David ^a   Friedman, Michael ^a   Srour, Wassim ^a   Raz, Itamar ^b   Hoffman, Amnon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Controlled release; Gastroretentive; Metformin; Pharmacodynamics; Pharmacokinetics

Indexed keywords

GLUCOSE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BOLUS INJECTION; CONTINUOUS INFUSION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG RETENTION; GASTROINTESTINAL ABSORPTION; GLUCOSE BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAVENOUS; MALE; METFORMIN; RATS; STOMACH; TABLETS;

EID: 0035848418     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(00)00374-6     Document Type: Article

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