Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models

Biomaterials

Volumn 25, Issue 15, 2004, Pages 3041-3048

  Adikwu, Michael U ^a,b   Yoshikawa, Yukako ^a   Takada, Kanji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF NIGERIA   (Nigeria)

Author keywords

Metformin HCl; Mucoadhesive formulation; Pharmacodynamic pharmacokinetic profile; Polysaccharide

Indexed keywords

BLOOD; DISEASES; GLUCOSE; LIVING SYSTEMS STUDIES; PHARMACOKINETICS; POLYSACCHARIDES;

ANTIDIABETIC PROPERTIES; BLOOD-GLUCOSE LEVELS;

BIOMATERIALS;

ADHESIVE AGENT; ANTIDIABETIC AGENT; METFORMIN; POLYSACCHARIDE; SODIUM DERIVATIVE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG METABOLISM; DRUG RELEASE; EVALUATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TABLET;

DETARIUM;

EID: 1142309720     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2003.09.073     Document Type: Article

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