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Volumn 39, Issue 1, 2013, Pages 6-10

Analogs of pancreatic polypeptide and peptide YY with a locked PP-fold structure are biologically active

Author keywords

Food intake regulation; Neuropeptide Y2 receptor; Neuropeptide Y4 receptor; Pancreatic polypeptide; Peptide YY; Protein structure; Tertiary

Indexed keywords

CYSTEINE; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; PANCREAS POLYPEPTIDE; PEPTIDE YY;

EID: 84869882523     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2012.10.010     Document Type: Article
Times cited : (17)

References (30)
  • 1
    • 0011918368 scopus 로고
    • Molecular structure of mammalian neuropeptide Y: Analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue
    • J. Allen, J. Novotny, J. Martin, and G. Heinrich Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue Proc Natl Acad Sci USA 84 1987 2532 2536
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2532-2536
    • Allen, J.1    Novotny, J.2    Martin, J.3    Heinrich, G.4
  • 2
    • 0033383202 scopus 로고    scopus 로고
    • Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
    • A. Asakawa, A. Inui, N. Ueno, M. Fujimiya, M.A. Fujino, and M. Kasuga Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice Peptides 20 1999 1445 1448
    • (1999) Peptides , vol.20 , pp. 1445-1448
    • Asakawa, A.1    Inui, A.2    Ueno, N.3    Fujimiya, M.4    Fujino, M.A.5    Kasuga, M.6
  • 6
    • 0024529531 scopus 로고
    • Highly potent and small neuropeptide y agonist obtained by linking NPY 1-4 via spacer to alpha-helical NPY 25-36
    • A. Beck, G. Jung, W. Gaida, H. Koppen, R. Lang, and G. Schnorrenberg Highly potent and small neuropeptide Y agonist obtained by linking NPY 1-4 via spacer to alpha-helical NPY 25-36 FEBS Lett 244 1989 119 122
    • (1989) FEBS Lett , vol.244 , pp. 119-122
    • Beck, A.1    Jung, G.2    Gaida, W.3    Koppen, H.4    Lang, R.5    Schnorrenberg, G.6
  • 7
    • 0036083943 scopus 로고    scopus 로고
    • The neuropeptide y monomer in solution is not folded in the pancreatic-polypeptide fold
    • A. Bettio, M.C. Dinger, and A.G. Beck-Sickinger The neuropeptide Y monomer in solution is not folded in the pancreatic-polypeptide fold Protein Sci 11 2002 1834 1844
    • (2002) Protein Sci , vol.11 , pp. 1834-1844
    • Bettio, A.1    Dinger, M.C.2    Beck-Sickinger, A.G.3
  • 8
    • 0019413468 scopus 로고
    • X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone
    • T.L. Blundell, J.E. Pitts, I.J. Tickle, S.P. Wood, and C.W. Wu X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: small globular protein hormone Proc Natl Acad Sci USA 78 1981 4175 4179
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 4175-4179
    • Blundell, T.L.1    Pitts, J.E.2    Tickle, I.J.3    Wood, S.P.4    Wu, C.W.5
  • 9
    • 0034031434 scopus 로고    scopus 로고
    • Molecular characterization of the ligand-receptor interaction of the neuropeptide y family
    • C. Cabrele, and A.G. Beck-Sickinger Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family J Pept Sci 6 2000 97 122
    • (2000) J Pept Sci , vol.6 , pp. 97-122
    • Cabrele, C.1    Beck-Sickinger, A.G.2
  • 10
    • 0033852143 scopus 로고    scopus 로고
    • Y family of peptides: Structure, anatomical expression, function, and molecular evolution
    • J.M. Cerda-Reverter, and Larhammar D. Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution Biochem Cell Biol 78 2000 371 392
    • (2000) Biochem Cell Biol , vol.78 , pp. 371-392
    • Cerda-Reverter, J.M.1    Neuropeptide, L.D.2
  • 11
    • 63849300305 scopus 로고    scopus 로고
    • Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs
    • M.R. Druce, J.S. Minnion, B.C. Field, S.R. Patel, J.C. Shillito, and M. Tilby Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs Endocrinology 150 2009 1712 1722
    • (2009) Endocrinology , vol.150 , pp. 1712-1722
    • Druce, M.R.1    Minnion, J.S.2    Field, B.C.3    Patel, S.R.4    Shillito, J.C.5    Tilby, M.6
  • 13
    • 79955479144 scopus 로고    scopus 로고
    • Structural dynamics of neuropeptide hPYY
    • W.A. Hegefeld, K. Kuczera, and G.S. Jas Structural dynamics of neuropeptide hPYY Biopolymers 95 2011 487 502
    • (2011) Biopolymers , vol.95 , pp. 487-502
    • Hegefeld, W.A.1    Kuczera, K.2    Jas, G.S.3
  • 14
    • 0030603862 scopus 로고    scopus 로고
    • Structure-affinity studies of C-terminally modified analogs of neuropeptide y led to a novel class of peptidic Y1 receptor antagonist
    • S. Hoffmann, B. Rist, G. Videnov, G. Jung, and A.G. Beck-Sickinger Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonist Regul Pept 65 1996 61 70
    • (1996) Regul Pept , vol.65 , pp. 61-70
    • Hoffmann, S.1    Rist, B.2    Videnov, G.3    Jung, G.4    Beck-Sickinger, A.G.5
  • 15
    • 0033405532 scopus 로고    scopus 로고
    • Neuropeptide families and their receptors: Evolutionary perspectives
    • C.H. Hoyle Neuropeptide families and their receptors: evolutionary perspectives Brain Res 848 1999 1 25
    • (1999) Brain Res , vol.848 , pp. 1-25
    • Hoyle, C.H.1
  • 16
    • 0034663977 scopus 로고    scopus 로고
    • Solution structure of monomeric peptide YY supports the functional significance of the PP-fold
    • D.A. Keire, M. Kobayashi, T.E. Solomon, and J.R. Reeve Jr. Solution structure of monomeric peptide YY supports the functional significance of the PP-fold Biochemistry 39 2000 9935 9942
    • (2000) Biochemistry , vol.39 , pp. 9935-9942
    • Keire, D.A.1    Kobayashi, M.2    Solomon, T.E.3    Reeve, Jr.J.R.4
  • 17
    • 0345598174 scopus 로고
    • Centrally truncated and stabilized porcine neuropeptide y analogs: Design, synthesis, and mouse brain receptor binding
    • J.L. Krstenansky, T.J. Owen, S.H. Buck, K.A. Hagaman, and L.R. McLean Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding Proc Natl Acad Sci USA 86 1989 4377 4381
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 4377-4381
    • Krstenansky, J.L.1    Owen, T.J.2    Buck, S.H.3    Hagaman, K.A.4    McLean, L.R.5
  • 18
    • 0029867643 scopus 로고    scopus 로고
    • Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
    • D. Larhammar Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide Regul Pept 62 1996 1 11
    • (1996) Regul Pept , vol.62 , pp. 1-11
    • Larhammar, D.1
  • 19
    • 3042621483 scopus 로고    scopus 로고
    • Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide y (NPY) are related to their affinity profiles at the y receptors
    • M. Lerch, M. Mayrhofer, and O. Zerbe Structural similarities of micelle-bound peptide YY (PYY) and neuropeptide Y (NPY) are related to their affinity profiles at the Y receptors J Mol Biol 339 2004 1153 1168
    • (2004) J Mol Biol , vol.339 , pp. 1153-1168
    • Lerch, M.1    Mayrhofer, M.2    Zerbe, O.3
  • 20
    • 0031919929 scopus 로고    scopus 로고
    • XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors
    • M.C. Michel, A. Beck-Sickinger, H. Cox, H.N. Doods, H. Herzog, and D. Larhammar XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors Pharmacol Rev 50 1998 143 150
    • (1998) Pharmacol Rev , vol.50 , pp. 143-150
    • Michel, M.C.1    Beck-Sickinger, A.2    Cox, H.3    Doods, H.N.4    Herzog, H.5    Larhammar, D.6
  • 21
    • 34548449003 scopus 로고    scopus 로고
    • Probing the formation of stable tertiary structure in a model miniprotein at atomic resolution: Determinants of stability of a helical hairpin
    • A. Neumoin, J. Mares, M. Lerch-Bader, R. Bader, and O. Zerbe Probing the formation of stable tertiary structure in a model miniprotein at atomic resolution: determinants of stability of a helical hairpin J Am Chem Soc 129 2007 8811 8817
    • (2007) J Am Chem Soc , vol.129 , pp. 8811-8817
    • Neumoin, A.1    Mares, J.2    Lerch-Bader, M.3    Bader, R.4    Zerbe, O.5
  • 22
    • 33745841347 scopus 로고    scopus 로고
    • The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
    • R. Nygaard, S. Nielbo, T.W. Schwartz, and F.M. Poulsen The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR Biochemistry 45 2006 8350 8357
    • (2006) Biochemistry , vol.45 , pp. 8350-8357
    • Nygaard, R.1    Nielbo, S.2    Schwartz, T.W.3    Poulsen, F.M.4
  • 23
    • 84865177176 scopus 로고    scopus 로고
    • Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36
    • S.L. Pedersen, V.K. Bhatia, S. Jurt, J.F. Paulsson, M.H. Pedersen, and R. Jorgensen Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36 J Pept Sci 18 2012 579 587
    • (2012) J Pept Sci , vol.18 , pp. 579-587
    • Pedersen, S.L.1    Bhatia, V.K.2    Jurt, S.3    Paulsson, J.F.4    Pedersen, M.H.5    Jorgensen, R.6
  • 24
    • 70449643294 scopus 로고    scopus 로고
    • Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity
    • S.L. Pedersen, B. Holst, N. Vrang, and K.J. Jensen Modifying the conserved C-terminal tyrosine of the peptide hormone PYY3-36 to improve Y2 receptor selectivity J Pept Sci 15 2009 753 759
    • (2009) J Pept Sci , vol.15 , pp. 753-759
    • Pedersen, S.L.1    Holst, B.2    Vrang, N.3    Jensen, K.J.4
  • 25
    • 77950663205 scopus 로고    scopus 로고
    • Peptide architecture: Adding an alpha-helix to the PYY lysine side chain provides nanomolar binding and body-weight-lowering effects
    • S.L. Pedersen, P.G. Sasikumar, N. Vrang, and K.J. Jensen Peptide architecture: adding an alpha-helix to the PYY lysine side chain provides nanomolar binding and body-weight-lowering effects Chem. Med. Chem 5 2010 545 551
    • (2010) Chem. Med. Chem , vol.5 , pp. 545-551
    • Pedersen, S.L.1    Sasikumar, P.G.2    Vrang, N.3    Jensen, K.J.4
  • 26
    • 0026705132 scopus 로고
    • Truncated, branched, and/or cyclic analogs of neuropeptide Y: Importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands
    • M.T. Reymond, L. Delmas, S.C. Koerber, M.R. Brown, and J.E. Rivier Truncated, branched, and/or cyclic analogs of neuropeptide Y: importance of the pancreatic peptide fold in the design of specific Y2 receptor ligands J Med Chem 35 1992 3653 3659
    • (1992) J Med Chem , vol.35 , pp. 3653-3659
    • Reymond, M.T.1    Delmas, L.2    Koerber, S.C.3    Brown, M.R.4    Rivier, J.E.5
  • 27
    • 0022470397 scopus 로고
    • The vasoconstrictor effect of neuropeptide y and related peptides in the Guinea pig isolated heart
    • F. Rioux, H. Bachelard, J.C. Martel, and S. St-Pierre The vasoconstrictor effect of neuropeptide Y and related peptides in the Guinea pig isolated heart Peptides 7 1986 27 31
    • (1986) Peptides , vol.7 , pp. 27-31
    • Rioux, F.1    Bachelard, H.2    Martel, J.C.3    St-Pierre, S.4
  • 28
    • 0029361837 scopus 로고
    • A rational approach for the development of reduced-size analogs of neuropeptide y with high affinity to the Y1 receptor
    • B. Rist, H.A. Wieland, K.D. Willim, and A.G. Beck-Sickinger A rational approach for the development of reduced-size analogs of neuropeptide Y with high affinity to the Y1 receptor J Pept Sci 1 1995 341 348
    • (1995) J Pept Sci , vol.1 , pp. 341-348
    • Rist, B.1    Wieland, H.A.2    Willim, K.D.3    Beck-Sickinger, A.G.4
  • 29
    • 0024503412 scopus 로고
    • Peptide-YY and neuropeptide-Y inhibit vasoactive intestinal peptide-stimulated adenosine 3′,5′-monophosphate production in rat small intestine: Structural requirements of peptides for interacting with peptide-YY-preferring receptors
    • A.L. Servin, C. Rouyer-Fessard, A. Balasubramaniam, S. Saint Pierre, and M. Laburthe Peptide-YY and neuropeptide-Y inhibit vasoactive intestinal peptide-stimulated adenosine 3′,5′-monophosphate production in rat small intestine: structural requirements of peptides for interacting with peptide-YY-preferring receptors Endocrinology 124 1989 692 700
    • (1989) Endocrinology , vol.124 , pp. 692-700
    • Servin, A.L.1    Rouyer-Fessard, C.2    Balasubramaniam, A.3    Saint Pierre, S.4    Laburthe, M.5
  • 30
    • 3843089529 scopus 로고    scopus 로고
    • Gut hormones and the control of appetite
    • C.J. Small, and S.R. Bloom Gut hormones and the control of appetite Trends Endocrinol Metabol 15 2004 259 263
    • (2004) Trends Endocrinol Metabol , vol.15 , pp. 259-263
    • Small, C.J.1    Bloom, S.R.2


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