Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36

Journal of Peptide Science

Volumn 18, Issue 9, 2012, Pages 579-587

  Pedersen, Søren L ^a   Bhatia, Vikram K ^b,c   Jurt, Simon ^d   Paulsson, Johan F ^e   Pedersen, Maria H ^a   Jorgensen, Rasmus ^e   Holst, Birgitte ^b   Stamou, Dimitrios ^a   Vrang, Niels ^f   Zerbe, Oliver ^d   Jensen, Knud J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NOVOZYMES A S   (Denmark)

^d UNIVERSITY OF ZURICH   (Switzerland)

^e NOVO NORDISK A S   (Denmark)

^f Gubra ApS   (Denmark)

Author keywords

Gut hormone; Membrane binding; NMR; Obesity; PYY3 36; Y2 receptor agonist

Indexed keywords

IODINE 125; PEPTIDE HORMONE; PEPTIDE YY [3-36];

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN TISSUE; HYDROPHOBICITY; MEMBRANE BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOLID PHASE SYNTHESIS;

AMINO ACID SEQUENCE; CELL MEMBRANE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR SEQUENCE DATA; PEPTIDE HORMONES; PEPTIDE YY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865177176     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2436     Document Type: Article

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