Peptide architecture: Adding an a-helix to the PYY lysineside chain provides nanomolar binding and body-weight-lowering effects

ChemMedChem

Volumn 5, Issue 4, 2010, Pages 545-551

  Pedersen, Søren L ^a,b   Sasikumar, Pottayil G ^c   Vrang, Niels ^b   Jensen, Knud J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Electronic City Phase II ^*  (Denmark)

^c Aurigene Discovery Technologies Limited   (India)

Author keywords

Agonists; Amphipathic a helices; Gut hormones; Obesity; Receptors; Y2

Indexed keywords

ANOREXIGENIC AGENT; LEUCYLASPARAGINYLARGINYLTYROSYLTYROSYLALANYLSERYLLEUCYLARGINYLHISTIDYLTYROSYLLEUCYLASPARAGINYLLEUCYLVALINE; LYSINE; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; PEPTIDE DERIVATIVE; PEPTIDE YY [17-31]; PEPTIDE YY [3-36]; PEPTIDE YY [31-17]; UNCLASSIFIED DRUG; VALYLLEUCYLASPARAGINYLLEUCYLTYROSYLHISTIDYLARGINYLLEUCYLSERYLALANYLTYROSYLTYROSYLARGINYLASPARAGINYLLEUCINE;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; WEIGHT REDUCTION;

AMINO ACID SEQUENCE; ANIMALS; ANTI-OBESITY AGENTS; CELL LINE; CIRCULAR DICHROISM; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE YY; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; WEIGHT LOSS;

EID: 77950663205     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200900521     Document Type: Article

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