Initial evaluation of a nano-engineered hemostatic agent in a severe vascular and organ hemorrhage swine model

Journal of Trauma and Acute Care Surgery

Volumn 73, Issue 5, 2012, Pages 1180-1187

  Arnaud, Françoise ^a,b   Okada, Tomoaki ^a   Solomon, Daniel ^c   Haque, Ashraful ^a   Carroll, Erica E ^a   Sagini, Eilleen ^a   McCarron, Richard ^a,b  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b Uniformed Services University of the Health Sciences   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bleeding; Hemostatic dressing; Liver repair; Nanofibers; Trauma

Indexed keywords

HEMOSTATIC AGENT; HETASTARCH; NANOFIBER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY PUNCTURE; ARTICLE; BANDAGES AND DRESSINGS; BLEEDING; BLOOD PRESSURE; CONTROLLED STUDY; DISEASE SEVERITY; FLUID RESUSCITATION; INGUINAL REGION; LIVER INJURY; NANOENGINEERING; NONHUMAN; PRIORITY JOURNAL; SHEAR RATE; SURFACE PROPERTY; SWINE;

ANIMALS; BANDAGES; DISEASE MODELS, ANIMAL; FEMORAL ARTERY; HEMORRHAGE; HEMOSTATICS; LIVER; NANOFIBERS; SILICON COMPOUNDS; SURFACE PROPERTIES; SUS SCROFA; WOUNDS, PENETRATING;

EID: 84869879885     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31825b3a60     Document Type: Article

References (28)

1. Kelly JF, Ritenour AE, McLaughlin DF, et al. Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. J Trauma. 2008;64:S21YS26.
2. Eastridge BJ, Hardin M, Cantrell J, et al. Died of wounds on the battlefield: causation and implications for improving combat casualty care. J Trauma. 2011;71:S4YS8.
3. Arnaud F, Teranishi K, Tomori T, CarrW, McCarron R. Comparison of ten hemostatic dressings in a groin puncture model in swine. J Vasc Surg. 2009;50: 632-639.
4. Arnaud F, Parreño-Sadalan D, Tomori T, et al. Comparison of 10 hemostatic dressings in a groin transection model in swine. J Trauma. 2009;67: 848-855.
5. Arnaud F, Teranishi K, Okada T, Parreño Sacdalan D, Hupalo D, McNamee G, Carr W, Burris D, McCarron R. Comparison of Combat Gauze and TraumaStat in two severe groin injury models. J Surg Res. 2011;169: 92-98.
6. Kheirabadi BS, Scherer MR, Estep JS, Dubick MA, Holcomb JB. Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine. J Trauma. 2009;67: 450-459.
7. Committee on Tactical Combat Casualty Care. CoTCCC recommendations. Available at: http://www.itstactical.com/2009/07/10/2009-tccc-guidelines. Accessed February 2009.
8. Kheirabadi BS, Acheson EM, Deguzman R, Sondeen JL, Ryan KL, Delgado A, Dick EJ Jr, Holcomb JB. Hemostatic eff icacy of two advanced dressings in an aortic hemorrhage model in Swine. J Trauma. 2005;59: 25-34.
9. Sambasivan CN, Schreiber MA. Emerging therapies in traumatic hemorrhage control. Curr Opin Crit Care. 2009;15: 560-568.
10. Kozen BG, Kircher SJ, Henao J, Godinez FS, Johnson AS. An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med. 2008;15: 74-81.
11. Delgado AV, Kheirabadi BS, Fruchterman TM, Scherer M, Cortez D,Wade CE, Dubick MA, Holcomb JB. A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury. J Trauma. 2008;64: 75-80.
12. Pusateri AE, Modrow HE, Harris RA, et al. Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine. J Trauma. 2003;55: 518-526.
13. Pusateri AE, Delgado AV, Dick EJ Jr, Martinez RS, Holcomb JB, Ryan KL. Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. J Trauma. 2004;57: 555-562.
14. Cui Y, Lauhon LJ, Gudiksen MS, Wang JF, Lieber CM. Diametercontrolled synthesis of single-crystal silicon nanowires. Appl Phys Lett. 2001;78;2214-2216.
15. Kheirabadi BS, Arnaud F, McCarron R, MurdockAD, Hodge DL, Ritter B, Dubick MA, Blackbourne LH. Development of a standard swine hemorrhage model for efficacy assessment of topical hemostatic agents. J Trauma. 2011;71:S139YS146.
16. Griffin JH. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proc Natl Acad Sci U S A. 1978; 75: 1998-2002.
17. Kheirabadi BS, Edens JW, Terrazas IB, Estep JS, Klemcke HG, Dubick MA, Holcomb JB. Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine. J Trauma. 2009;66: 316-326.
18. Gordy SD, Rhee P, Schreiber MA. Military applications of novel hemostatic devices. Expert Rev Med Devices. 2011;8: 41-47.
19. Hartgerink JD, Granja JR, Milligan RA, Ghadiri MR. Self-assembling peptide nanotube. J Am Chem Soc. 1996;118: 43-50.
20. Heller M,Wei C. Self-assembly peptide prevents blood loss. Nanomedicine. 2006;2:216.
21. Ellis-Behnke RG, Liang YX, Tay DK, Kau PW, Schneider GE, Zhang S, Wu W, So KF. Nano hemostat solution: immediate hemostasis at the nanoscale. Nanomedicine. 2006;2: 207-215.
22. Ellis-Behnke R. At the nanoscale: nanohemostat, a new class of hemostatic agent. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3: 70-78.
23. Pursifull NF, Morey AF. Tissue glues and non-suturing techniques. Curr Opin Urol. 2007;17: 396-401.
24. Kheirabadi BS, Mace JE, Terrazas IB, Fedyk CG, Estep JS, Dubick MA, Blackbourne LH. Safety evaluation of new hemostatic agents, smectite granules, and kaolin-coated gauze in a vascular injury wound model in swine. J Trauma. 2010;68: 269-278.
25. Turaev AS. Dependence of the biodegradability of carboxymethylcellulose on its supermolecular structure and molecular parameters. Chem Nat Compd. 1996;31: 254-259.
26. Tomizawa Y. Clinical benefits and risk analysis of topical hemostats: a review. J Artif Organs. 2005;8: 137-142.
27. Valentine R, Wormald PJ, Sindwani R. Advances in absorbable biomaterials and nasal packing. Otolaryngol Clin North Am. 2009; 42: 813-828.
28. Institute of Medicine. Novel approaches to treatment of shock. In: Fluid Resuscitation: State of the Science for Treating Combat Casualties and Civilian Injuries.Washington, DC: National Academy Press; 1999: 79-96