Active self-healing encapsulation of vaccine antigens in PLGA microspheres

Journal of Controlled Release

Volumn 165, Issue 1, 2013, Pages 62-74

  Desai, Kashappa Goud H ^a   Schwendeman, Steven P ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Active loading; Controlled release; Encapsulation; PLGA; Self healing; Vaccine delivery

Indexed keywords

ACTIVE LOADING; CONTROLLED RELEASE; PLGA; SELF-HEALING; VACCINE DELIVERY;

ALUMINUM; ANTIGENS; CALCIUM PHOSPHATE; COPOLYMERS; ENCAPSULATION; MICROSPHERES; ORGANIC SOLVENTS; PACKAGING; PLASTICIZERS; POLYMERS; PROTEINS; REINFORCED PLASTICS; SOLVENTS; VACCINES;

LOADING;

ACETYLCITRIC ACID TRIBUTYL ESTER; ALUMINUM HYDROXIDE; CALCIUM PHOSPHATE; MICROSPHERE; OVALBUMIN; PHTHALIC ACID DIETHYL ESTER; PLASTICIZER; POLYGLACTIN; TETANUS TOXOID; TREHALOSE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DRUG ADSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; HYDROPHOBICITY; MICROENCAPSULATION; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANTIGENS; CALCIUM PHOSPHATES; CITRATES; DRUG COMPOUNDING; LACTIC ACID; MICROSPHERES; PHTHALIC ACIDS; PLASTICIZERS; POLYGLYCOLIC ACID; TETANUS TOXOID; TREHALOSE; VACCINES;

EID: 84869862247     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.012     Document Type: Article

References (46)

1. M. Diwan, R.K. Khar, and G.P. Talwar Tetanus toxoid loaded 'preformed microspheres' of cross-linked dextran Vaccine 19 2001 3853 3859 (Pubitemid 32566306)
2. J.H. Wilson-Welder, M.P. Torres, M.J. Kipper, S.K. Mallapragada, M.J. Wannemuehler, and B. Narasimhan Vaccine adjuvants: current challenges and future approaches J. Pharm. Sci. 98 2009 1278 1316
3. D.T. O'Hagan, and R. Rappuoli Novel approaches to pediatric vaccine delivery Adv. Drug Deliv. Rev. 58 2006 29 51
4. S.P. Schwendeman, M. Tobio, M. Joworowicz, M.J. Alonso, and R. Langer New strategies for the microencapsulation of tetanus vaccine J. Microencapsul. 15 1998 299 318 (Pubitemid 28190667)
5. W.L. Jiang, R.K. Gupta, M.C. Deshpande, and S.P. Schwendeman Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens Adv. Drug Deliv. Rev. 57 2005 391 410 (Pubitemid 39550967)
6. G.F.A. Kersten, D. Donders, A. Akkermans, and E.C. Beuvery Single shot with tetanus toxoid in biodegradable microspheres protects mice despite acid-induced denaturation of the antigen Vaccine 14 1996 1627 1632 (Pubitemid 27041914)
7. M.J. Alonso, R.K. Gupta, C. Min, G.R. Siber, and R. Langer Biodegradable microspheres as controlled-release tetanus toxoid delivery systems Vaccine 12 1994 299 306 (Pubitemid 24071950)
8. A.G.A. Coombes, E.C. Lavelle, P.G. Jenkins, and S.S. Davis Single dose, polymeric, microparticle based vaccines: the influence of formulation conditions on the magnitude and duration of the immune response to a protein antigen Vaccine 14 1996 1429 1438 (Pubitemid 27008258)
9. Y. Men, C. Thomasin, H.P. Merkle, B. Gander, and G. Corradin A single administration of tetanus toxoid in biodegradable microspheres elicits T cell and antibody responses similar or superior to those obtained with aluminum hydroxide Vaccine 13 1995 683 689
10. M. Singh, X.M. Li, H.Y. Wang, J.P. McGee, T. Zamb, W. Koff, C.Y. Wang, and D.T. Ohagan Immunogenicity and protection in small-animal models with controlled-release tetanus toxoid microparticles as a single-dose vaccine Infect. Immun. 65 1997 1716 1721 (Pubitemid 27193591)
11. M.T. Aguado, and P.H. Lambert Controlled-release vaccines-biodegradable polylactide polyglycolide (PL/LG) microspheres as antigen vehicles Immunobiology 184 1992 113 125
12. Y. Waeckerie-Men, B. Gander, and M. Groettrup Delivery of tumor antigens to dendritic cells using biodegradable microspheres Methods Mol. Med. 109 2005 35 46
13. M.J. Alonso, S. Cohen, T.G. Park, R.K. Gupta, G.R. Siber, and R. Langer Determinants of release rate of tetanus vaccine from polyester microspheres Pharm. Res. 10 1993 945 953 (Pubitemid 23211414)
14. A. Sanchez, B. Villamayor, Y.Y. Guo, J. McIver, and M.J. Alonso Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres Int. J. Pharm. 185 1999 255 266 (Pubitemid 29392911)
15. M. Tobio, J. Nolley, Y.Y. Guo, J. McIver, and M.J. Alonso A novel system based on a poloxamer PLGA blend as a tetanus toxoid delivery vehicle Pharm. Res. 16 1999 682 688 (Pubitemid 29227098)
16. S.P. Schwendeman Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems Crit. Rev. Ther. Drug Carrier Syst. 19 2002 73 98 (Pubitemid 34521249)
17. W.L. Jiang, and S.P. Schwendeman Stabilization of tetanus toxoid encapsulated in PLGA microspheres Mol. Pharm. 5 2008 808 817
18. A.C. Chang, and R.K. Gupta Stabilization of tetanus toxoid in poly(dl-lactic-co-glycolic acid) microspheres for the controlled release of antigen J. Pharm. Sci. 85 1996 129 132 (Pubitemid 26055792)
19. P. Johansen, H. Tamber, H.P. Merkle, and B. Gander Diphtheria and tetanus toroid microencapsulation into conventional and end-group alkylated PLA/PLGAs Eur. J. Pharm. Biopharm. 47 1999 193 201 (Pubitemid 29257878)
20. P. Johansen, F. Estevez, R. Zurbriggen, H.P. Merkle, R. Gluck, G. Corradin, and B. Gander Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres Vaccine 19 2000 1047 1054 (Pubitemid 32008269)
21. M. Murillo, C. Gamazo, M.M. Goñi, J.M. Irache, and M.J. Blanco-Príeto Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis Int. J. Pharm. 242 2002 341 344
22. P. Johansen, Y. Men, R. Audran, G. Corradin, H.P. Merkle, and B. Gander Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives Pharm. Res. 15 1998 1103 1110 (Pubitemid 28356930)
23. Y.K. Katare, and A.K. Panda Influences of excipients on in vitro release and in vivo performance of tetanus toxoid loaded polymer particles Eur. J. Pharm. Sci. 28 2006 179 188 (Pubitemid 43766098)
24. T. Morita, Y. Sakamura, Y. Horikiri, T. Suzuki, and H. Yoshino Protein encapsulation into biodegradable microspheres by a novel S/O/W emulsion method using poly(ethylene glycol) as a protein micronization adjuvant J. Control. Release 69 2000 435 444
25. C. Perez-Rodriguez, N. Montano, K. Gonzalez, and K. Griebenow Stabilization of alpha-chymotrypsin at the CH2Cl2/water interface and upon water-in-oil-in-water encapsulation in PLGA microspheres J. Control. Release 89 2003 71 85 (Pubitemid 36412115)
26. A.J. Baxendale, P. van Hooff, L.G. Durrant, I. Spendlove, S.M. Howdle, H.M. Woods, M.J. Whitaker, O.R. Davies, A. Naylor, A.L. Lewis, and L. Illum Single shot tetanus vaccine manufactured by a supercritical fluid encapsulation technology Int. J. Pharm. 413 2011 147 154
27. F. Wu, and T. Jin Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances AAPS PharmSciTech 9 2008 1218 1229
28. J.A. Syrett, C.R. Becer, and D.M. Haddleton Self-healing and self-mendable polymers Polym. Chem. 1 2010 978 987
29. R.P. Wool Self-healing materials: a review Soft Matter 4 2008 400 418 (Pubitemid 351304293)
30. J. Wang, B.A. Wang, and S.P. Schwendeman Characterization of the initial burst release of a model peptide from poly(d,l-lactide-co-glycolide) microspheres J. Control. Release 82 2002 289 307 (Pubitemid 34880185)
31. S.P. Schwendeman, S.E. Reinhold, and J. Kang Methods for Encapsulation of Biomacromolecules in Polymers, US8017155 2005
32. S.E. Reinhold, K.G.H. Desai, L. Zhang, K.F. Olsen, and S.P. Schwendeman Self-healing microencapsulation of biomacromolecules without organic solvents Angew. Chem. Int. Ed. 51 2012 10800 10803
33. S.P. Schwendeman, and K.G.H. Desai Active Self-healing Biomaterial System, WO/2011/088229 2011
34. L.S. Jones, L.J. Peek, J. Power, A. Markham, B. Yazzie, and C.R. Middaugh Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens J. Biol. Chem. 280 2005 13406 13414 (Pubitemid 40517228)
35. D.P. Jiang, G.S. Premachandra, C. Johnston, and S.L. Hem Structure and adsorption properties of commercial calcium phosphate adjuvant Vaccine 23 2004 693 698 (Pubitemid 39473201)
36. R.K. Gupta, and G.R. Siber Adjuvants for human vaccines-current status, problems and future prospects Vaccine 13 1995 1263 1276
37. J.E. Rosas, R.M. Hernandez, A.R. Gascon, M. Igartua, F. Guzman, M.E. Patarroyo, and J.L. Pedraz Biodegradable PLGA microspheres as a delivery system for malaria synthetic peptide SPf66 Vaccine 19 2001 4445 4451 (Pubitemid 32718668)
38. Y. Waeckerle-Men, E.U.-v. Allmen, B. Gander, E. Scandella, E. Schlosser, G. Schmidtke, H.P. Merkle, and M. Groettrup Encapsulation of proteins and peptides into biodegradable poly(d,l-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells Vaccine 24 2006 1847 1857 (Pubitemid 43238266)
39. M. Igartua, R.M. Hernandez, A. Esquisabel, A.R. Gascon, M.B. Calvo, and J.L. Pedraz Enhanced immune response after subcutaneous and oral immunization with biodegradable PLGA microspheres J. Control. Release 56 1998 63 73 (Pubitemid 28511127)
40. A.L. Clausi, S.A. Merkley, J.F. Carpenter, and T.W. Randolph Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying J. Pharm. Sci. 97 2008 2049 2061
41. J.L. Cleland, A. Lim, L. Barron, E.T. Duenas, and M.F. Powell Development of a single-shot subunit vaccine for HIV-1.4. Optimizing microencapsulation and pulsatile release of MN rgp120 from biodegradable microspheres J. Control. Release 47 1997 135 150 (Pubitemid 27212341)
42. M.J. Santander-Ortega, N. Csaba, L. Gonzalez, D. Bastos-Gonzalez, J.L. Ortega-Vinuesa, and M.J. Alonso Protein-loaded PLGA-PEO blend nanoparticles: encapsulation, release and degradation characteristics Colloid Polym. Sci. 288 2010 141 150
43. M.L. Ye, S. Kim, and K. Park Issues in long-term protein delivery using biodegradable microparticles J. Control. Release 146 2010 241 260
44. G.L. Morefield, D. Jiang, I.Z. Romero-Mendez, R.L. Geahlen, H. HogenEsch, and S.L. Hem Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid Vaccine 23 2005 1502 1506 (Pubitemid 40164710)
45. J.C. Kang, and S.P. Schwendeman Pore closing and opening in biodegradable polymers and their effect on the controlled release of proteins Mol. Pharm. 4 2007 104 118
46. J.C. Kang, and S.P. Schwendeman Determination of diffusion coefficient of a small hydrophobic probe in poly(lactide-co-glycolide) microparticles by laser scanning confocal microscopy Macromolecules 36 2003 1324 1330