Circadian regulation of low density lipoprotein receptor promoter activity by CLOCK/BMAL1, Hes1 and Hes6

Experimental and Molecular Medicine

Volumn 44, Issue 11, 2012, Pages 642-652

  Lee, Yeon Ju ^a   Han, Dong Hee ^a   Pak, Youngmi Kim ^a,b   Cho, Sehyung ^a,b  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

ARNTL transcription factors; Circadian rhythm; CLOCK proteins; HES1 protein; HES6 protein; Human; LDL; Receptors

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN BMAL1; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HES 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; HOMEOSTASIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION SITE; UPREGULATION;

EID: 84869755310     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.11.073     Document Type: Article

References (36)

1. Al Rayyes O, Wallmark A, Floren CH. Additive inhibitory effect of hydrocortisone and cyclosporine on low-density lipoprotein receptor activity in cultured HepG2 cells. Hepatology 1997;26:967-71
2. Bae S, Bessho Y, Hojo M, Kageyama R. The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development 2000;127:2933-43
3. Balasubramaniam S, Szanto A, Roach PD. Circadian rhythm in hepatic low-density-lipoprotein (LDL)-receptor expression and plasma LDL levels. Biochem J 1994;298:39-43
4. Briggs MR, Yokoyama C, Wang X, Brown MS, Goldstein JL. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem 1993;268:14490-6
5. Brown MS, Goldstein JL. A receptor-mediated pathway for cholesterol homeostasis. Science 1986;232:34-4
6. Cho S, Cho H, Geum D, Kim K. Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragments and GT1-1 neuronal cells in vitro. Brain Res Mol Brain Res 1998;54: 74-84
7. Doi M, Cho S, Yujnovsky I, Hirayama J, Cermakian N, Cato AC, Sassone-Corsi P. Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons. J Biol Rhythms 2007;22:127-39
8. Dunlap JC. Molecular bases for circadian clocks. Cell 1999; 96:271-90
9. Edwards PA, Muroya H, Gould RG. In vivo demonstration of the circadian rhythm of cholesterol biosynthesis in the liver and intestine of the rat. J Lipid Res 1972;13:396-401
10. Ellsworth JL, Carlstrom AJ, Deikman J. Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene. Biochim Biophys Acta 1994;1210:321-8
11. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990;343:425-30
12. Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol 2009; 29:431-8
13. Gramantieri L, Giovannini C, Lanzi A, Chieco P, Ravaioli M, Venturi A, Grazi GL, Bolondi L. Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. Liver Int 2007;27:997-1007
14. Green CB, Takahashi JS, Bass J. The meter of metabolism. Cell 2008;134:728-42
15. Ha M, Park J. Shiftwork and metabolic risk factors of cardiovascular disease. J Occup Health 2005;47:89-95
16. Hazra A, Pyszczynski NA, DuBois DC, Almon RR, Jusko WJ. Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats. Pharm Res 2008;25:769-80
17. Ishida A, Mutoh T, Ueyama T, Bando H, Masubuchi S, Nakahara D, Tsujimoto G, Okamura H. Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab 2005;2:297-307
18. Jeong JH, Cho S, Pak YK. Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor γ coactivator-1a (PGC-1α). Exp Mol Med 2009;41:406-16
19. Ko CH, Takahashi JS. Molecular components of the mammalian. Hum Mol Genet 2006;15:R271-7 Knutsson A. Health disorders of shift workers. Occup Med (Lond) 2003;53:103-8
20. Moore RY. Organization and function of a central nervous system circadian oscillator: The suprachiasmatic hypothalamic nucleus. Fed Proc 1983;42:2783-9
21. Murai K, Vernon AE, Philpott A, Jones P. Hes6 is required for MyoD induction during gastrulation. Dev Biol 2007;312: 61-76
22. Noh JY, Han DH, Yoon JA, Kim MH, Kim SE, Ko IG, Kim KH, Kim CJ, Cho S. Circadian rhythms in urinary functions: possible roles of circadian clocks? Int Neurourol J 2011;15: 64-73
23. Panda S, Hogenesch JB. It's all in the timing: many clocks, many outputs. J Biol Rhythms 2004;19:374-87
24. Pak YK, Kanuck MP, Berrios D, Briggs MR, Cooper AD, Ellsworth JL. Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor. J Lipid Res 1996; 37:985-98
25. Park WH, Pak YK. Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms. Exp Mol Med 2011;43: 571-9
26. Park N, Cheon S, Son GH, Cho S, Kim K. Chronic circadian disturbance by a shortened light-dark cycle increases mortality. Neurobiol Aging 2012;33:1122.e11-22
27. Roenneberg T, Merrow M. The network of time: understanding the molecular circadian system. Curr Biol 2003;13: R198-207
28. Sanchez-Alavez M, Klein I, Brownell SE, Tabarean IV, Davis CN, Conti B, Bartfai T. Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci USA 2007;104: 3009-14
29. Smith JR, Osborne TF, Goldstein JL, Brown MS. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J Biol Chem 1990;265:2306-10
30. Stokkan KA, Yamazaki S, Tei H, Sakaki Y, MenakerM. Entrainment of the circadian clock in the liver by feeding. Science 2001;291:490-3
31. Szosland D. Shift work and metabolic syndrome, diabetes mellitus and ischaemic heart disease. Int J Occup Med Environ Health 2010;23:287-91
32. Takahashi JS, Hong HK, Ko CH, McDearmon EL. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 2008;9:764-75
33. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, McDearmon E, Laposky A, Losee-Olson S, Easton A, Jensen DR, Eckel RH, Takahashi JS, Bass J. Obesity and metabolic syndrome in circadian clock mutant mice. Science 2005;308:1043-5
34. Wang X, Briggs MR, Hua X, Yokoyama C, Goldstein JL, Brown MS. Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization. J Biol Chem 1993;268: 14497-504
35. Whitmer RA, Gustafson DR, Barrett-Connor E, Haan MN, Gunderson EP, Yaffe K. Central obesity and increased risk of dementia more than three decades later. Neurology 2008; 71:1057-64
36. Yoon JA, Han DH, Noh JY, Kim MH, Son GH, Kim K, Kim K, Pak YK, Cho S. Meal time shift disturbs circadian rhythmicity with metabolic and behavioral alterations in mice. PLoS One 2012;7:e44053