68Ga small peptide imaging: Comparison of NOTA and PCTA

Bioconjugate Chemistry

Volumn 23, Issue 11, 2012, Pages 2239-2246

  Ferreira, Cara L ^a   Yapp, Donald T T ^b   Mandel, Derek ^a   Gill, Rajanvir K ^b   Boros, Eszter ^c,d   Wong, May Q ^b   Jurek, Paul ^e   Kiefer, Garry E ^e  

^a MDS Inc   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c TRIUMF   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e Macrocyclics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; MUSCLE; TUMORS;

BI-FUNCTIONAL; COLORECTAL TUMORS; INITIAL ACTIVITY; MUSCLE TISSUES; RADIOCHEMICAL YIELD; RADIOLABELLING; SPECIFIC ACTIVITY; TIME POINTS; TUMOR UPTAKE; TUMOUR XENOGRAFTS;

PEPTIDES;

1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; APOTRANSFERRIN; ARGINYLGLYCYLASPARTIC ACID; CHELATING AGENT; GALLIUM 68; PCTA CHELATE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COLORECTAL TUMOR; COMPLEX FORMATION; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG STABILITY; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; ISOTOPE LABELING; MASS SPECTROMETRY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOCHEMISTRY; ROOM TEMPERATURE; TISSUE DISTRIBUTION;

EID: 84869752698     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300348d     Document Type: Article

References (23)

1. 68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals Contr. Media Mol. Imaging 3, 53-62
2. 68Ga-labeled peptide Nucl. Med. Biol. 35, 529-536
3. 3 integrin expression Eur. J. Nucl. Med. Mol. Imaging 35, 1507-1515
4. 68Ga bioconjugates with high sepcific radioactivity Bioconjugate Chem. 15, 554-560
5. Shannon, R. D. (1976) Revised effective radii and systematic studies of interatomic distances in halide and chalcogenides Acta Crystallogr. A32, 751-767
6. Vallabhajosula, J. F., Harwig, J. K., Siemsen, N., and Wolf, W. (1980) Radiogallium localization in tumors: blood binding and the role of transferrin J. Nucl. Med. 225, 4629-4633
7. Velikyan, I., Maecke, H., and Langstrom, B. (2008) Convenient preparation of Ga-68 based PET-radiopharmaceuticals at room temperature Bioconjugate Chem. 19, 569-573
8. 68Ga-Labeled c(RGDyK)-Isothiocyanatobenzyl- 1,4,7-triazacyclononane-1,4,7-Triacetic Acid and Feasibility Studies in Mice J. Nucl. Med. 49, 830-836
9. 3 integrin expression and facile radiosynthesis J. Nucl. Med. 52, 1276-1284
10. Knetsch, P. A., Petrik, M., Griessinger, C. M., Rangger, C., Fani, M., Kesenhemer, C., von Guggenberg, E., Pichler, B. J., Virgolini, I., Decristoforo, C., and Haubner, R. (2011) [68Ga]NODAGA-RGD for imaging αvβ3 integrin expression Eur. J. Nucl. Med. Mol. Imaging 38, 1303-1312
11. Notni, J., Simecek, J., Hermann, P., and Wester, H.-J. (2011) TRAP, a powerful and verstaile framework for Gallium-68 radiopharmaceuticals Chem.-Eur. J. 17, 14718-14722
12. 68Ga]PET imaging of VEGF receptors in angiogenic vasculature Nucl. Med. Biol. 37, 405-412
13. 68Ga PET imaging agent elaboration J. Am. Chem. Soc. 132, 15726-15733
14. Ferreira, C. L., Lamsa, E., Woods, M., Duan, Y., Fernando, P., Bensimon, C., Kordos, M., Guenther, K., Jurek, P., and Kiefer, G. E. (2010) Evaluation of bifunctional chelates for development of gallium based radiopharmaceuticals Bioconjugate Chem. 21, 531-536
15. 3 expression Eur. J. Nucl. Med. Mol. Imaging 35, 1100-1108
16. 4 linkers Bioconjugate Chem. 20, 750-759
17. Baker, J. H. E., Lam, J., Kyle, A. H., Sy, J. T., Oliver, T., Co, S., Dragowska, W. H., Ramsay, E., Anatha, M., Ruth, T., Adam, M., Yung, A., Kozloxski, P., Minchinton, A. I., Ng, S. S. W., Bally, M. B., and Yapp, D. T. T. (2008) Irinophore CTM, a novel nano-formulation of irinotecan, alters tumor vascular function and enhances the distribution 5-FU and doxorubicin Clin. Cancer Res. 14, 7260-7271
18. Wieholt, C., Hsiao, I., Lin, K., Chung, Y., Chen, C., and Yen, T. (2008) Performance evaluation of small animal PET system using NEMA standards J. Nucl. Med. 49, 119P
19. 68Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice Eur. J. Nucl. Med. Mol. Imaging 36, 2058-2067
20. Singh, A. N., Liu, W., Hao, G., Kumar, A., Gupta, A., Oz, O. K., Hsieh, J.-T., and Sun, X. (2011) Multivalent bifunctional chelator scaffolds for Gallium-68 based positron emission tomography imaging probe design: signal amplication via multivalency Bioconjugate Chem. 22, 1650-1662
21. 3 expression Mol. Imaging 10, 386-397
22. Ma, M. T., Neels, O. C., Denoyer, D., Roselt, P., Karas, J. A., Scanlon, D. B., White, J. M., Hicks, R. J., and Donnelly, P. S. (2011) Gallium-68 complex of a macrobicyclic cage amine chelator tethered to two integrin-targeting peptides for diagnostic tumor imaging Bioconjugate Chem. 22, 2093-2103
23. 68Ga Nucl. Med. Biol. 39, 785-794