-
1
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
S.P. Staal Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma Proc Natl Acad Sci U S A 84 1987 5034 5037
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
2
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
D.A. Altomare, and J.R. Testa Perturbations of the AKT signaling pathway in human cancer Oncogene 24 2005 7455 7464
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
3
-
-
73449142838
-
Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH
-
T. Kirkegaard, C.J. Witton, and J. Edwards Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH Histopathology 56 2010 203 211
-
(2010)
Histopathology
, vol.56
, pp. 203-211
-
-
Kirkegaard, T.1
Witton, C.J.2
Edwards, J.3
-
4
-
-
59749095009
-
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer
-
Y.R. Chin, and A. Toker Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer Cell Signal 21 2009 470 476
-
(2009)
Cell Signal
, vol.21
, pp. 470-476
-
-
Chin, Y.R.1
Toker, A.2
-
5
-
-
33745307617
-
Ras, PI(3)K and mTOR signalling controls tumour cell growth
-
R.J. Shaw, and L.C. Cantley Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature 441 2006 424 430
-
(2006)
Nature
, vol.441
, pp. 424-430
-
-
Shaw, R.J.1
Cantley, L.C.2
-
6
-
-
0037229714
-
Overexpression of AKT2/protein kinase B beta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
M.J. Arboleda, J.F. Lyons, and F.F. Kabbinavar Overexpression of AKT2/protein kinase B beta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells Cancer Res 63 2003 196 206
-
(2003)
Cancer Res
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
-
7
-
-
0035896630
-
Protein kinase B beta/Akt2 plays a specific role in muscle differentiation
-
M. Vandromme, A. Rochat, and R. Meier Protein kinase B beta/Akt2 plays a specific role in muscle differentiation J Biol Chem 276 2001 8173 8179
-
(2001)
J Biol Chem
, vol.276
, pp. 8173-8179
-
-
Vandromme, M.1
Rochat, A.2
Meier, R.3
-
8
-
-
0032189381
-
Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
-
P.J. Coffer, J. Jin, and J.R. Woodgett Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation Biochem J 335 Pt 1 1998 1 13
-
(1998)
Biochem J
, vol.335
, Issue.PART 1
, pp. 1-13
-
-
Coffer, P.J.1
Jin, J.2
Woodgett, J.R.3
-
9
-
-
23944526062
-
Activation of AKT kinases in cancer: Implications for therapeutic targeting
-
A. Bellacosa, C.C. Kumar, A. Di Cristofano, and J.R. Testa Activation of AKT kinases in cancer: implications for therapeutic targeting Adv Cancer Res 94 2005 29 86
-
(2005)
Adv Cancer Res
, vol.94
, pp. 29-86
-
-
Bellacosa, A.1
Kumar, C.C.2
Di Cristofano, A.3
Testa, J.R.4
-
10
-
-
0029127042
-
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
-
A. Bellacosa, D. de Feo, and A.K. Godwin Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas Int J Cancer 64 1995 280 285
-
(1995)
Int J Cancer
, vol.64
, pp. 280-285
-
-
Bellacosa, A.1
De Feo, D.2
Godwin, A.K.3
-
11
-
-
1242286948
-
Frequent activation of AKT2 kinase in human pancreatic carcinomas
-
D.A. Altomare, S. Tanno, and A. De Rienzo Frequent activation of AKT2 kinase in human pancreatic carcinomas J Cell Biochem 87 2002 470 476
-
(2002)
J Cell Biochem
, vol.87
, pp. 470-476
-
-
Altomare, D.A.1
Tanno, S.2
De Rienzo, A.3
-
12
-
-
33751190974
-
Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms
-
K. Nakayama, N. Nakayama, and R.J. Kurman Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms Cancer Biol Ther 5 2006 779 785
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 779-785
-
-
Nakayama, K.1
Nakayama, N.2
Kurman, R.J.3
-
13
-
-
0035872199
-
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
J. Brognard, A.S. Clark, Y. Ni, and P.A. Dennis Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res 61 2001 3986 3997
-
(2001)
Cancer Res
, vol.61
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
14
-
-
20244376768
-
Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer
-
A. Shah, W.A. Swain, and D. Richardson Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer Clin Cancer Res 11 2005 2930 2936
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2930-2936
-
-
Shah, A.1
Swain, W.A.2
Richardson, D.3
-
15
-
-
78751572648
-
Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas
-
Y. Dobashi, S. Suzuki, and M. Kimura Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas Hum Pathol 42 2011 214 226
-
(2011)
Hum Pathol
, vol.42
, pp. 214-226
-
-
Dobashi, Y.1
Suzuki, S.2
Kimura, M.3
-
16
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
F. Cappuzzo, E. Magrini, and G.L. Ceresoli Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer J Natl Cancer Inst 96 2004 1133 1141
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
-
17
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
K. Stemke-Hale, A.M. Gonzalez-Angulo, and A. Lluch An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer Cancer Res 68 2008 6084 6091
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
-
18
-
-
0030598884
-
Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer
-
W. Miwa, J. Yasuda, and Y. Murakami Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer Biochem Biophys Res Commun 225 1996 968 974
-
(1996)
Biochem Biophys Res Commun
, vol.225
, pp. 968-974
-
-
Miwa, W.1
Yasuda, J.2
Murakami, Y.3
-
19
-
-
33750067086
-
Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays
-
N. Kagawa, M. Maruno, and T. Suzuki Detection of genetic and chromosomal aberrations in medulloblastomas and primitive neuroectodermal tumors with DNA microarrays Brain Tumor Pathol 23 2006 41 47
-
(2006)
Brain Tumor Pathol
, vol.23
, pp. 41-47
-
-
Kagawa, N.1
Maruno, M.2
Suzuki, T.3
-
20
-
-
15744373791
-
-
New York: Springer. Lyon: IARCPress
-
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. Pathology and genetics of tumours of the lung, pleura, thymus and heart. New York: Springer. Lyon: IARCPress, 2004.
-
(2004)
Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart
-
-
Travis, W.D.1
Brambilla, E.2
Muller-Hermelink, H.K.3
Harris, C.C.4
-
21
-
-
34548457234
-
The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
-
P. Goldstraw, J. Crowley, and K. Chansky The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours J Thorac Oncol 2 2007 706 714
-
(2007)
J Thorac Oncol
, vol.2
, pp. 706-714
-
-
Goldstraw, P.1
Crowley, J.2
Chansky, K.3
-
22
-
-
50349098499
-
Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3
-
D. Allard, N. Figg, M.R. Bennett, and T.D. Littlewood Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3 J Biol Chem 283 2008 19739 19747
-
(2008)
J Biol Chem
, vol.283
, pp. 19739-19747
-
-
Allard, D.1
Figg, N.2
Bennett, M.R.3
Littlewood, T.D.4
-
23
-
-
42449161420
-
Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma
-
F. Wu, S.Y. Liu, and Y.M. Tao Decreased expression of methyl methansulfonate and ultraviolet-sensitive gene clone 81 (Mus81) is correlated with a poor prognosis in patients with hepatocellular carcinoma Cancer 112 2008 2002 2010
-
(2008)
Cancer
, vol.112
, pp. 2002-2010
-
-
Wu, F.1
Liu, S.Y.2
Tao, Y.M.3
-
24
-
-
20444498630
-
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
-
F. Cappuzzo, F.R. Hirsch, and E. Rossi Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer J Natl Cancer Inst 97 2005 643 655
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
-
25
-
-
0033590636
-
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
-
R. Hoshino, Y. Chatani, and T. Yamori Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors Oncogene 18 1999 813 822
-
(1999)
Oncogene
, vol.18
, pp. 813-822
-
-
Hoshino, R.1
Chatani, Y.2
Yamori, T.3
-
26
-
-
61449126478
-
Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma
-
A. Ooi, S. Suzuki, and K. Nakazawa Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma Anticancer Res 29 2009 19 26
-
(2009)
Anticancer Res
, vol.29
, pp. 19-26
-
-
Ooi, A.1
Suzuki, S.2
Nakazawa, K.3
-
27
-
-
34248147439
-
Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: The EGFR fluorescence in situ hybridization assay
-
M. Varella-Garcia Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay Diagn Pathol 1 2006 19
-
(2006)
Diagn Pathol
, vol.1
, pp. 19
-
-
Varella-Garcia, M.1
-
28
-
-
77952522130
-
PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus
-
I.S. Kwon, K.H. Lee, J.W. Choi, and J.Y. Ahn PI(3,4,5)P3 regulates the interaction between Akt and B23 in the nucleus BMB Rep 43 2010 127 132
-
(2010)
BMB Rep
, vol.43
, pp. 127-132
-
-
Kwon, I.S.1
Lee, K.H.2
Choi, J.W.3
Ahn, J.Y.4
-
29
-
-
6044230919
-
Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
-
O. David, J. Jett, and H. LeBeau Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage Clin Cancer Res 10 2004 6865 6871
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6865-6871
-
-
David, O.1
Jett, J.2
Lebeau, H.3
-
30
-
-
0031748914
-
The causes and prevention of cancer: The role of environment
-
B.N. Ames, and L.S. Gold The causes and prevention of cancer: the role of environment Biotherapy 11 1998 205 220
-
(1998)
Biotherapy
, vol.11
, pp. 205-220
-
-
Ames, B.N.1
Gold, L.S.2
-
31
-
-
55549084534
-
Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors
-
P. Hou, M. Ji, and M. Xing Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors Cancer 113 2008 2440 2447
-
(2008)
Cancer
, vol.113
, pp. 2440-2447
-
-
Hou, P.1
Ji, M.2
Xing, M.3
-
32
-
-
73149092535
-
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells
-
M. de Frias, D. Iglesias-Serret, and A.M. Cosialls Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells Haematologica 94 2009 1698 1707
-
(2009)
Haematologica
, vol.94
, pp. 1698-1707
-
-
De Frias, M.1
Iglesias-Serret, D.2
Cosialls, A.M.3
-
33
-
-
34447125097
-
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
-
L.Z. Liu, X.D. Zhou, and G. Qian AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway Cancer Res 67 2007 6325 6332
-
(2007)
Cancer Res
, vol.67
, pp. 6325-6332
-
-
Liu, L.Z.1
Zhou, X.D.2
Qian, G.3
-
34
-
-
37549010727
-
Pharmacodynamic markers of perifosine efficacy
-
B.T. Hennessy, Y. Lu, and E. Poradosu Pharmacodynamic markers of perifosine efficacy Clin Cancer Res 13 2007 7421 7431
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7421-7431
-
-
Hennessy, B.T.1
Lu, Y.2
Poradosu, E.3
-
35
-
-
20344384859
-
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
-
Y. Luo, A.R. Shoemaker, and X. Liu Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo Mol Cancer Ther 4 2005 977 986
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 977-986
-
-
Luo, Y.1
Shoemaker, A.R.2
Liu, X.3
-
36
-
-
80054809459
-
Phase i pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
-
C.R. Garrett, D. Coppola, and R.M. Wenham Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT Invest New Drugs 29 2011 1381 1389
-
(2011)
Invest New Drugs
, vol.29
, pp. 1381-1389
-
-
Garrett, C.R.1
Coppola, D.2
Wenham, R.M.3
-
37
-
-
78651458656
-
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
-
S. Chandarlapaty, A. Sawai, and M. Scaltriti AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity Cancer Cell 19 2011 58 71
-
(2011)
Cancer Cell
, vol.19
, pp. 58-71
-
-
Chandarlapaty, S.1
Sawai, A.2
Scaltriti, M.3
|