Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma

Clinical Oral Investigations

Volumn 16, Issue 6, 2012, Pages 1549-1556

  Chaiyarit, Ponlatham ^a   Utrawichian, Akasith ^a   Leelayuwat, Chanvit ^a   Vatanasapt, Patrawut ^b   Chanchareonsook, Nattharee ^c   Samson, Mie Hessellund ^d   Giraud, Andrew S ^e  

^a KHON KAEN UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

^c National Dental Centre of Singapore   (Singapore)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

ELISA; Immunohistochemistry; Oral cancer; Saliva; Trefoil factors

Indexed keywords

ESTROGEN; GROWTH PROMOTOR; PEPTIDE; TFF1 PROTEIN, HUMAN; TFF3 PROTEIN, HUMAN; TREFOIL FACTOR; TUMOR MARKER; TUMOR SUPPRESSOR PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOPSY; CELL MEMBRANE; CHEMISTRY; COMPARATIVE STUDY; CYTOPLASM; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH TUMOR; PATHOLOGY; SALIVA; SQUAMOUS CELL CARCINOMA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CARCINOMA, SQUAMOUS CELL; CELL MEMBRANE; CYTOPLASM; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; ESTROGENS; FEMALE; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; PEPTIDES; SALIVA; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84869499272     PISSN: 14326981     EISSN: 14363771     Source Type: Journal    
DOI: 10.1007/s00784-011-0667-z     Document Type: Article

References (52)

1. Mori K, Fujii R, Kida N, Takahashi H, Ohkubo S, Fujino M, Ohta M, Hayashi K (1990) Complete primary structure of the human estrogen responsive gene (pS2) product. J Biochem 107: 73-6.
2. Tomasetto C, Rio M, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R (1990) hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in the stomach but not in breast carcinoma. EMBO J 9: 407-14.
3. Hauser F, Poulsom R, Chinery R, Rogers LA, Hanby AM, Wright NA, Hoffmann W (1993) hP1. B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 90: 6961-65.
4. Thim L, May FEB (2005) Structure of mammalian trefoil factors and functional insights. Cell Mol Life Sci 62: 2956-73.
5. Chinery R, Williamson J, Poulsom R (1996) The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22. 3 clustered with other members of the trefoil peptide family. Genomics 32: 281-4.
6. Madsen J, Nielsen O, Tornøe I, Thim L, Holmskov U (2007) Tissue localization of human trefoil factors 1, 2, and 3. J Histochem Cytochem 55: 505-13.
7. Jagla W, Wiede A, Dietzmann K, Rutkowski K, Hoffmann W (2000) Co-localization of TFF3 peptide and oxytocin in the human hypothalamus. FASEB J 14: 1126-31.
8. Paulsen FP, Hinz M, Schaudig U, Thale AB, Hoffmann W (2002) TFF peptides in the human efferent tear ducts. Invest Ophthalmol Vis Sci 43: 3359-64.
9. Jagla W, Wiede A, Hinz M, Dietzmann K, Gülicher D, Gerlach KL, Hoffmann W (1999) Secretion of TFF-peptides by human salivary glands. Cell Tissue Res 298: 161-6.
10. Devine DA, High AS, Owen PJ, Poulsom R, Bonass WA (2000) Trefoil factor expression in normal and diseased human salivary glands. Hum Pathol 31: 509-15.
11. Kouznetsova I, Gerlach KL, Zahl C, Hoffmann W (2010) Expression analysis of human salivary glands by laser microdissection: differences between submandibular and labial glands. Cell Physiol Biochem 26: 375-82.
12. Kutta H, May J, Jaehne M, Münscher A, Paulsen FP (2006) Antimicrobial defence mechanisms of the human parotid duct. J Anat 208: 609-19.
13. dos Santos SE, Ulrich M, Döring G, Botzenhart K, Gött P (2000) Trefoil factor family domain peptides in the human respiratory tract. J Pathol 190: 133-42.
14. Cook GA, Familari M, Thim L, Giraud AS (1999) The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response. FEBS Lett 456: 155-9.
15. Srivatsa G, Giraud AS, Ulaganathan M, Yeomans ND, Dow C, Nicoll AJ (2002) Biliary epithelial trefoil peptide expression is increased in biliary diseases. Histopathology 40: 261-8.
16. Wiede A, Hinz M, Canzler E, Franke K, Quednow C, Hoffmann W (2001) Synthesis and localization of the mucin-associated TFF-peptides in the human uterus. Cell Tissue Res 303: 109-15.
17. Vestergaard EM, Poulsen SS, Grønbaek H, Larsen R, Nielsen AM, Ejskjaer K, Clausen JT, Thim L, Nexø E (2002) Development and evaluation of an ELISA for human trefoil factor 3. Clin Chem 48: 1689-95.
18. Vestergaard EM, Brynskov J, Ejskjaer K, Clausen JT, Thim L, Nexø E, Poulsen SS (2004) Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease. Scand J Clin Lab Invest 64: 146-56.
19. Vestergaard EM, Nexø E, Wendt A, Guthmann F (2008) Trefoil factors in human milk. Early Hum Dev 84: 631-5.
20. Kouznetsova I, Peitz U, Vieth M, Meyer F, Vestergaard EM, Malfertheiner P, Roessner A, Lippert H, Hoffmann W (2004) A gradient of TFF3 (trefoil factor family 3) peptide synthesis within the normal human gastric mucosa. Cell Tissue Res 316: 155-65.
21. Rasmussen TN, Thim L, Raaberg L, Harling H, Holst JJ (1990) Pancreatic spasmolytic polypeptide, a potential growth factor for the intestine: neural control of secretion. Digestion 46: 226-31.
22. Rasmussen TN, Harling H, Thim L, Pierzynowski S, Weström BR, Holst JJ (1993) Regulation of secretion of pancreatic spasmolytic polypeptide from porcine pancreas. Am J Physiol 264: 22-9.
23. Miyashita S, Nomoto H, Konishi H, Hayashi K (1994) Estimation of pS2 protein level in human body fluids by a sensitive two-site enzyme immunoassay. Clin Chim Acta 228: 71-81.
24. Goldenring JR, Poulsom R, Ray GS, Wright N, Meise KS, Coffey RJ Jr (1996) Expression of trefoil peptides in the gastric mucosa of transgenic mice overexpressing transforming growth factor-alpha. Growth Factors 13: 111-9.
25. Taupin D, Wu DC, Jeon WK, Devaney K, Wang TC, Podolsky DK (1999) The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation. J Clin Invest 103: 31-8.
26. Jackerott M, Lee YC, Møllgård K, Kofod H, Jensen J, Rohleder S, Neubauer N, Gaarn LW, Lykke J, Dodge R, Dalgaard LT, Søstrup B, Jensen DB, Thim L, Nexø E, Thams P, Bisgaard HC, Nielsen JH (2006) Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Endocrinology 147: 5752-9.
27. Tu S, Chi AL, Lim S, Cui G, Dubeykovskaya Z, Ai W, Fleming JV, Takaishi S, Wang TC (2007) Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways. Am J Physiol Gastrointest Liver Physiol 292: 1726-37.
28. Nikolaidis NM, Zimmermann N, King NE, Mishra A, Pope SM, Finkelman FD, Rothenberg ME (2003) Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung. Am J Respir Cell Mol Biol 29: 458-64.
29. Dossinger V, Kayademir T, Blin N, Gött P (2002) Down-regulation of TFF expression in gastrointestinal cell lines by cytokines and nuclear factors. Cell Physiol Biochem 12: 197-206.
30. van De Bovenkamp JH, Korteland-van Male AM, Büller HA, Einerhand AW, Dekker J (2005) Infection with Helicobacter pylori affects all major secretory cell populations in the human antrum. Dig Dis Sci 50: 1078-86.
31. Fox JG, Rogers AB, Whary MT, Ge Z, Ohtani M, Jones EK, Wang TC (2007) Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171: 1520-8.
32. Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, Malki S, Alderman BM, Grail D, Hollande F, Heath JK, Ernst M (2002) Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8: 1089-97.
33. Baus-Loncar M, Giraud AS (2005) Multiple regulatory pathways for trefoil factor (TFF) genes. Cell Mol Life Sci 62: 2921-31.
34. Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM (1995) Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology 108: 108-16.
35. Tran CP, Cook GA, Yeomans ND, Thim L, Giraud AS (1999) Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis. Gut 44: 636-42.
36. Carrasco R, Pera M, May FE, Westley BR, Martinez A, Morales L (2004) Trefoil factor family peptide 3 prevents the development and promotes healing of ischemia-reperfusion injury in weanling rats. J Pediatr Surg 39: 1693-700.
37. Mashimo H, Wu DC, Podolsky DK, Fishman MC (1996) Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 274: 262-5.
38. Poulsen SS, Thulesen J, Hartmann B, Kissow HL, Nexø E, Thim L (2003) Injected TFF1 and TFF3 bind to TFF2-immunoreactive cells in the gastrointestinal tract in rats. Regul Pept 115: 91-9.
39. Liu D, el-Hariry I, Karayiannakis AJ, Wilding J, Chinery R, Kmiot W, McCrea PD, Gullick WJ, Pignatelli M (1997) Phosphorylation of beta-catenin and epidermal growth factor receptor by intestinal trefoil factor. Lab Invest 77: 557-63.
40. Lalani EN, Williams R, Jayaram Y, Gilbert C, Chaudhary KS, Siu LS, Koumarianou A, Playford R, Stamp GW (1999) Trefoil factor-2, human spasmolytic polypeptide, promotes branching morphogenesis in MCF-7 cells. Lab Invest 79: 537-46.
41. Rodrigues S, van Aken E, van Bocxlaer S, Attoub S, Nguyen QD, Bruyneel E, Westley BR, May FE, Thim L, Mareel M, Gespach C, Emami S (2003) Trefoil peptides as proangiogenic factors in vivo and in vitro: implication of cyclooxygenase-2 and EGF receptor signaling. FASEB J 17: 7-16.
42. Storesund T, Hayashi K, Kolltveit KM, Bryne M, Schenck K (2008) Salivary trefoil factor 3 enhances migration of oral keratinocytes. Eur J Oral Sci 116: 135-40.
43. Storesund T, Schenck K, Osmundsen H, Røed A, Helgeland K, Kolltveit KM (2009) Signal transduction and gene transcription induced by TFF3 in oral keratinocytes. Eur J Oral Sci 117: 511-7.
44. Perry JK, Kannan N, Grandison PM, Mitchell MD, Lobie PE (2008) Are trefoil factors oncogenic? Trends Endocrinol Metab 19: 74-81.
45. Vestergaard EM, Borre M, Poulsen SS, Nexø E, Tørring N (2006) Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clin Cancer Res 12: 807-12.
46. Emami S, Rodrigues S, Rodrigue CM, Le Floch N, Rivat C, Attoub S, Bruyneel E, Gespach C (2004) Trefoil factor family (TFF) peptides and cancer progression. Peptides 25: 885-98.
47. Samson MH, Chaiyarit P, Nortvig H, Vestergaad EM, Ernst E, Nexø E (2011) Trefoil factor family peptides in human saliva and in cyclical cervical mucus. Method evaluation and results on healthy individuals. Clin Chem Lab Med 49. doi: 10. 1515/CCLM. 2011. 123.
48. Taupin D, Pedersen J, Familari M, Cook G, Yeomans N, Giraud AS (2001) Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. Lab Invest 81: 397-408.
49. Taupin DR, Pang KC, Green SP, Giraud AS (1995) The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut. Peptides 16: 1001-5.
50. Verey F, Nexø E, Greenwood R, Berry M, Corfield AP (2011) Trefoil factor family peptides are increased in the saliva of children with mucositis. Clin Chem Lab Med. doi: 10. 1515/CCLM. 2011. 667.
51. Regalo G, Wright NA, Machado JC (2005) Trefoil factors: from ulceration to neoplasia. Cell Mol Life Sci 62: 2910-15.
52. Peterson AJ, Menheniott TR, O'Connor L, Walduck AK, Fox JG, Kawakami K, Minamoto T, Ong EK, Wang TC, Judd LM, Giraud AS (2010) Helicobacter pylori infection methylates and silences trefoil factor 2 leading to gastric tumor development in mice and humans. Gastroenterology 139: 2005-17.