Update on Liposarcoma: A review for cytopathologists

Diagnostic Cytopathology

Volumn 40, Issue 12, 2012, Pages 1122-1131

  Dodd, Leslie G ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

chondroid lipoma; dedifferentiated liposarcoma; lipoblastoma; liposarcoma; myxoid liposarcoma; pleomorphic lipoma; pleomorphic liposarcoma; spindle cell lipoma; well differentiated liposarcoma

Indexed keywords

CYCLIN DEPENDENT KINASE 4; PROTEIN MDM2; PROTEIN P53;

ADIPOCYTE; CANCER PROGNOSIS; CELL CYCLE ARREST; CELL DIFFERENTIATION; CHONDROID LIPOMA; CHROMOSOME ABERRATION; CHROMOSOME REARRANGEMENT; CYTOGENETICS; CYTOPATHOLOGY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; LIPOSARCOMA; MIXED LIPOSARCOMA; MYXOID ROUND CELL LIPOSARCOMA; NEEDLE BIOPSY; PLEOMORPHIC LIPOMA; PLEOMORPHIC LIPOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPINDLE CELL LIPOMA; WELL DIFFERENTIATED LIPOSARCOMA;

ADIPOCYTES; BIOPSY, FINE-NEEDLE; CYTOGENETIC ANALYSIS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOSARCOMA; NEOPLASM GRADING; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS C-MDM2; SOFT TISSUE NEOPLASMS; TRANSLOCATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84869490774     PISSN: 87551039     EISSN: 10970339     Source Type: Journal    
DOI: 10.1002/dc.21794     Document Type: Review

References (103)

1. Fletcher C, Unni K, Mertens F, editors. Pathology and genetics of tumors of soft tissue and bone. Lyon, France: International Agency for Research on Cancer Press; 2002.
2. Howlader N, Noone AM, Krapcho M, et al., editors. SEER cancer statistics review, 1975-2008. Bethesda, MD: National Cancer Institute. Available at: http://seer.cancer.gov/csr/1975-2008/.
3. Matushansky I, Henrnando E, Socci ND, et al. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest 2007; 117: 3248-3257.
4. Dalal KM, Antonescu CR, Singer S,. Diagnosis and management of lipomatous tumors. J Surg Oncol 2008; 97: 298-231.
5. Rosai J, Akerman M, Dal Cin P, et al. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors: Evaluation of their relationship and differential diagnosis with other adipose tumors (A report of the CHAMP study group). Am J Surg Pathol 1996: 20: 1182-1189.
6. Fletcher CDM, Akerman M, Dal Cin P, et al. Correlation between clinicopathogical features and karotype in lipomatous tumors. A report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study group. Am J Pathol 1996; 148: 623-630.
7. Tallini G, Akerman M, Dal Cin P, et al. Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing. Am J Surg Pathol 1996; 20: 1047-1055.
8. Fritz B, Schubert F, Wrobel G, et al. Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 2002; 62: 2993-2998.
9. Singer S, Socci ND, Ambrosini G, et al. Gene expression profiling of liposarcoma identified distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Cancer Res 2007; 67: 6626-6636.
10. Gobble RM, Qin LX, Brill ER, et al. Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Cancer Res 2011; 71: 2697-2705.
11. Coindre JM, Pedeutour F, Aurias A,. Well-differentiated and dedifferentiated liposarcomas. Virchows Arch 2010; 456: 167-179.
12. Dalal KM, Kattan MW, Atonescu CR, et al. Subtype specific prognostic nomogram for patients with primary liposarcoma of the retroperitoneum, extremity or trunk. Ann Surg 2006; 244: 381-391.
13. Stephenson CF, Berger CS, Leong SP, et al. Analysis of a giant marker chromosome in a well-differentiated liposarcoma using cytogenetics and fluorescent in situ hybridization. Cancer Genet Cytogent 1992; 61: 134-138.
14. Dal Cin P, Kools P, Sciot R, et al. Cytogenetic and fluorescent in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 1993; 68: 85-90.
15. Pedetour F, Forus A, Coindre JM, et al. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer 1999; 24: 30-41.
16. Nilbert M, Rydholm A, Willen H, Mitelman F, Mandahl N,. MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors. Genes Chromosomes Cancer 1994; 9: 261-265.
17. Dei Tos A, Doglioni C, Piccinin S, et al. Coordinated expression and amplification of the MDM2, CDK4 and HMGI-C genes in atypical lipomatous tumors. J Pathol 2000; 190: 531-536.
18. Oliner JD, Pientenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B,. Oncoprotein MDM2 conceals the activation domain of tumor suppressor p53. Nature 1993; 362: 857-860.
19. Freedman DA, Wu L, Levine AJ,. Functions of the MDM2 oncoprotein. Cell Mol Life Sci 1999; 55: 96-107.
20. Binh MBN, Sastre-Garau X, Guillou L, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes. A comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 2005; 29: 1340-1347.
21. Alexio PB, Hartmann AA, Menezes IC, Meurer RT, Oliveira AM,. Can MDM2 and CDK4 make the diagnosis of well differentiated/dedifferentiated liposarcoma? An immunohistochemical study on 129 soft tissue tumours. J Clin Pathol 2009; 62: 1127-1136.
22. Zhang H, Erickson-Johnson M, Wang X,. Molecular testing for lipomatous tumors: Critical analysis and test recommendations based on analysis of 405 extremity based tumors. Am J Surg Pathol 2010; 34: 1304-1311.
23. Walaas L, Kindblom LG,. Lipomatous tumors: A correlative cytologic and histologic study of 27 tumors examined by fine needle aspiration cytology. Hum Pathol 1985; 16: 6-18.
24. Miralles TG, Gosalbez F, Menendez P, et al. Fine needle aspiration of soft-tissue lesions. Acta Cytol 1986; 30: 671-678.
25. Layfield LJ, Anders KH, Glasgow BJ, et al. Fine-needle aspiration of primary soft-tissue lesions. Arch Pathol Lab Med 1986; 110: 420-424.
26. Akerman M, Rydholm A,. Aspiration cytology of lipomatous tumors: A 10-year experience at an orthopedic oncology center. Diagn Cytopathol 1987; 3: 295-302.
27. Shattuck MC, Victor TA,. Cytologic features of well-differentiated sclerosing liposarcoma in aspirated samples. Acta Cytol 1988; 32: 896-901.
28. Dey P,. Fine needle aspiration of well-differentiated liposarcoma. A report of two cases. Acta Cytol 2000; 44: 459-462.
29. Della Palma P, Barbazza R,. Well-differentiated liposarcoma of the paratesticular area: Report of a case with fine-needle aspiration preoperative diagnosis and review of the literature. Diagn Cytopathol 1990; 6: 421-426.
30. Layfield LJ,. Cytopathology of bone and soft tissue tumors. Oxford University Press: New York; 2002.
31. Klijanienko J, Caillaud JM, Lagace R,. Fine-needle aspiration in liposarcoma: Cytohistologic correlative study including well-differentiated, myxoid and pleomorphic variants. Diagn Cytopathol 2004; 30: 307-312.
32. Weaver J, Rao P, Goldblum JR, et al. Can MDM2 analytical tests performed on core needle biopsy be relied upon to diagnose well-differentiated liposarcoma? Modern Pathol 2010; 23: 1301-1306.
33. Al-Maghabry HQ, Khalbuss WE, Rao UN, et al. Fine needle aspiration biopsy diagnosis of dedifferentiated liposarcoma: Cytomorphology and MDM2 amplification by FISH. Cytojournal 2010; 7: 5.
34. Henricks WD, Chu YC, Goldblum JR, Weiss SW,. Dedifferentiated liposarcoma: A clinicopathologic analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol 1997; 21: 271-281.
35. Weiss SW, Goldblum JR,. 2008. Enzinger and Weiss's soft tissue tumors, 5th ed. Philadelphia: Mosby Elsevier. 498 p.
36. Singer S, Antonescu CR, Riedel E, Brennan MF,. Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg 2003; 238: 358-371.
37. Fanburg-Smith JC, Mietten M,. Liposarcoma with meningothelial-like whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology 1998; 33: 414-424.
38. Nascimento AG, Kurtin PJ, Guillou L, et al. Dedifferentiated liposarcoma: A report of nine cases with a peculiar neural like whirling pattern associated with metaplastic bone formation. Am J Surg Pathol 1998; 22: 945-955.
39. Song JS, Gardner JM, Tarrant WP, et al. Dedifferentiated liposarcoma with peculiar meningothelial-like whirling and metaplastic bone formation. Ann Diagn Pathol 2009; 13: 278-284.
40. Hasegawa T, Seki K, Hasegawa F, et al. Dedifferentiated liposarcoma of retroperitoneum and mesentery: Varied growth patterns and histological grades-A clinicopathologic study of 32 cases. Human Pathol 2000; 31: 717-727.
41. Liu D, Quinonex G, Latosinsky S,. Dedifferentiated liposarcoma with a paraganglioma-like histologic pattern: A case report andreview of the literature. Arch Pathol Lab Med 2004; 128: 788-791.
42. Matsumoto T, Fukunaga M, Fujii H, et al. Inguinal dedifferentiated liposarcoma with meningothelial-like whorls and metaplastic bone formation. Histopathology 2005; 436: 594-596.
43. Misra V, Singh P, Singh PA, Ahmad S,. Cytodiagnosis of dedifferentiated liposarcoma clinically masquerading as a renal tumor. Cytopathology 2009; 20: 195-198.
44. Geethamani V, Savithri R, Suguna BV, Niveditha SR,. Cytomorphology of dedifferentiated liposarcoma of the subcutis of the back with axillary lymph node metastases: A case report. Acta Cytol 2010; 54: 333-336.
45. Guo Z, Voytovich M, Kurtycz DF, Hoerl HD,. Fine-needle aspiration diagnosis of spindle-cell lipoma: A case report and review of the literature. Diagn Cytopathol 2000; 23: 362-365.
46. Domanski HA, Carlen B, Jonsson K, Mertens F, Akerman M,. Distinct cytologic features of spindle cell lipoma. A cytologic-histologic study with clinical, radiologic, electron microscopic and cytogenetic correlations. Cancer 2001; 93: 381-389.
47. Fasig JH, Robinson RA, McCulloch TM, Fletcher MS, Miller CK,. Spindle cell lipoma of the parotid: Fine needle aspiration and histologic findings. Arch Pathol Lab Med 2001; 125: 820-821.
48. Agoff SN, Folpe AL, Grieco VS, Garcia RL,. Spindle cell lipoma of the oral cavity. Report of a rare intramuscular case with fine needle aspiration findings. Acta Cytol 2001; 45: 93-98.
49. Pathan SK, Kapila K, Al-Ayadhy B, Abdeen S,. Spindle cell lipoma: An uncommon tumor with distinctive morphology. Cytopathology 2007; 18: 123-125.
50. Viega M, Fresno MF, Madrigan B, Alvarez De Los Heros C,. Pleomorphic lipoma on fine-needle aspiration cytology. Acta Cytol 1998; 42: 1489-1490.
51. Thiramala S, Desai M, Kannan V,. Diagnostic pitfalls in fine needle aspiration cytology of pleomorphic lipoma. A case report. Acta Cytol 2000; 44: 653-656.
52. Lopez-Rios F, Alberti V, Perez-Barrios A, De Agustin PP,. Fine needle aspiration of pleomorphic lipoma. Diagn Cytopathol 2001; 24: 296-297.
53. Young M, Raza AS, Greaves TS, Cobb CJ,. Fine-needle aspiration of a pleomorphic lipoma of the head and neck: A case report. Diagn Cytopathol 2005; 32: 110-113.
54. Chen X, Yu K, Tong GX, Hood M, Storper I, Hamele-Bena D,. Fine needle aspiration of pleomorphic lipoma of the neck: Report of two cases. Diagn Cytopathol 2010; 38: 184-187.
55. Crozat A, Aman P, Mandahl N, Ron D,. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993; 363: 640-644.
56. Rabbitts TH, Forster A, Larson R, Nathan P,. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat Genet 1993; 4: 175-180.
57. Knight JC, Renwick PJ, Dal Cin P, Vand den Berghe H, Fletcher CDM,. Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: Molecular and cytogenetic analysis. Cancer Res 1995; 55: 24-27.
58. Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV,. Kinome profiling of myxoid liposarcoma reveals NF-kappaB pathway kinase activity and casein kinase II inhibition as a potential treatment option. Mol Cancer 2010; 9: 257.
59. Gonzalez-Compora R, Otal-Salaverri C, Hevia-Vasquez A, et al. Fine needle aspiration in myxoid tumors of the soft tissues. Acta Cytol 1990; 34: 179-191.
60. Szadowska A, Lasota J,. Fine needle aspiration cytology of myxoid liposarcoma: A study of 18 tumors. Cytopathology 1993; 4: 99-106.
61. Wakely PE, Geisinger KR, Cappellari JO, et al. Fine needle aspiration cytopathology of soft tissue: Chondromyxoid and myxoid lesions. Diagn Cytopathol 1995; 12: 101-105.
62. Layfield LJ, Liu K, Dodge RK,. Logistic regression analysis of myxoid sarcomas: A cytologic study. Diagn Cytopathol 1998; 19: 355-360.
63. Wakely PE,. Myxomatous soft tissue tumors: Correlation of cytopathology and histopathology. Ann Diagn Pathol 1999; 3: 227-242.
64. Nemanqani D, Mourad WA,. Cytomorphologic features of fine-needle aspiration of liposarcoma. Diagn Cytopathol 1999; 20: 67-69.
65. Pantanowitz L, Otis C,. Myxoid liposarcoma. Diagn Cytopathol 2007; 283-284.
66. Vicandi B, Jimenez-Heffernan J, Lopez-Ferrer P, Gonzalez-Peramato P, Viguer JMK,. Cytologic features of round cell liposarcoma: A report on five patients. Cancer 2003; 99: 28-32.
67. Smith TA, Easly KA, Goldblum JR,. Myxoid/round cell liposarcoma of the extremities. A clinicopatholgic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 1996; 20: 171-180.
68. Kilpatrick SE, Doyon J, Choong PF, Sim FH, Nascimento AG,. The clinicopathologic spectrum of myxoid and round cell liposarcoma. A study of 95 cases. Cancer 1996; 77: 1450-1458.
69. Antonescu CR, Tshernyavsky SJ, Decuseara R, et al. Prognostic impact of p53 status, TLS-Chop fusion transcript structure, and histological grade in myxoid liposarcoma: A molecular and clinicopathologic study of 82 cases. Clin Cancer Res 2001; 7: 3977-3987.
70. Ten Heuvel SE, Hoekstra HJ, van Grinkel RJ, Bastiaannet E, Suurmeijer AJH,. Clinicopathologic prognostic factors in myxoid liposarcoma: A retrospective study of 49 patients with long-term follow-up. Ann Surg Oncol 2007; 14: 222-229.
71. Fiore M, Groso F, Lo Vullo S, et al. Myxoid/round cell and pleomorphic liposarcoma. Diagnostic factors and survival in a series of patients at a single institution. Cancer 2007; 109: 2522-2531.
72. Mentzel T, Calonje E, Fletcher CD,. Lipoblastoma and lipoblastomatosis: A clinicopathological study of 14 cases. Histopathology 1993; 6: 527-533.
73. Collins MH, Chatten J,. Lipoblastoma/lipoblastomatosis: A clinicopathologic study of 25 tumors. Am J Surg Pathol 1997; 10: 1131-1137.
74. Coffin CM, Lowichik A, Putnam A,. Lipoblastoma (LPB): A clinicopatholgic and immunohistochemical analysis of 59 cases. Am J Surg Pathol 2009; 11: 1705-1712.
75. Pollono DG, Tomarchio S, Drut R, et al. Retroperitoneal and deep-seated lipoblastoma: Diagnosis by CT scan and fine-needle aspiration biopsy. Diagn Cytopathol 1999; 20: 295-297.
76. Leon ME, Deschler D, Wu SS, Galindo LM,. Fine needle aspiration diagnosis of lipoblastoma of the parotid region. A case report. Acta Cytol 2002; 46: 395-404.
77. Lopez-Ferrer P, Jimenez-Heffernan JA, Yebenes L, Vicandi B, Viguer JM,. Fine needle aspiration of Lipoblastoma: A report of two cases. Diagn Cytopathol 2005; 32: 32-34.
78. Kloboves-Prevodnk VV, Us-Krasovec M, Gale N, Lamovec J,. Cytological features of lipoblastoma: A report of three cases. Diagn Cytopathol 2005; 33: 195-200.
79. Hong R, Choi DY, Do NY, Lim SC,. Fine-needle aspiration cytology of lipoblastoma: A case report. Diagn Cytopathol 2008; 36: 508-511.
80. Yang YJ, Damron TA, Ambrose JL,. Diagnosis of chondroid lipoma by fine-needle aspiration biopsy. Arch Pathol Lab Med 2001; 125: 1224-1226.
81. Jimenez-Hefferman JA, Gonzalez-Permato P, Pema C,. Diagnosis of chondroid lipoma by fine-needle aspiration biopsy. Arch Pathol Lab Med 2002; 126: 773.
82. Huang D, Sumegi J, Cal Cin P, et al. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. Genes Chromosomes Cancer 2010; 49: 810-818.
83. Downes KA, Goldblum JR, Montgomery EA, et al. Pleomorphic liposarcoma: A clinicopathologic analysis of 19 cases. Mod Pathol 2001; 14: 179-184.
84. Gebhard S, Coindre JM, Michels JJ, et al. Pleomorphic liposarcoma: Clinicopathologic, immunohistochemical and follow-up analysis of 63 cases: A study from the French federation of cancer centers sarcoma group. Am J Surg Pathol 2002; 26: 601-616.
85. Hornick JL, Bosenberg MW, Mentzel T, et al. Pleomorophic liposarcoma: Clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004; 28: 1257-1267.
86. Guillou L, Aurias A,. Soft tissue sarcomas with complex genomic profiles. Virchow Archiv 2010; 456: 201-217.
87. Miettinen M, Enzinger FM,. Epithelioid variant of pleomorphic liposarcoma: A study of 12 cases of a distinctive variant of high-grade liposarcoma. Modern Pathol 1999; 12: 722-728.
88. Demaria S, Yee HT, Cangiarella J, Cohen JM, Chhieng DC,. Fine needle aspiration of primary pleomorphic liposarcoma of the breast. A case report. Acta Cytol 1999; 43: 1131-1136.
89. Romero-Guadarrama MB, Jimenez-Becerra S, Duran-Padilla MA, Santiago-Prieto AC, Cruz-Ortiz H, Novela-Retana V,. Mediastinal pleomorphic liposarcoma diagnosed by fine needle aspiration biopsy: A case report. Acta Cytol 2007; 51: 440-442.
90. Apostolou G, Biteli M, Chatzipantelis P,. Cytopathological diagnosis of metastatic pleomorphic liposarcoma in the lung: A report of a case correlated with the histopathology of the primary tumor. Diagn Cytopathol 2009; 37: 667-670.
91. Boland JM, Weiss SW, Oliveira AM, Erickson-Johnson ML, Folpe AL,. Liposarcomas with mixed well-differentiated and pleomorphic features: A clinicopathologic study of 12 cases. Am J Surg Pathol 2010; 34: 837-843.
92. Altungoz O, Meloni AM,., Peier A, Zalupski M, Spanier S, Brooks JSJ, Sandberg A,. Deletion 6q in three cases of mixed-type liposarcoma in addition to t(12;16)(q13;p11). Cancer Genet Cytogenet 1995; 79: 104-110.
93. Mentzel T, Fletcher CDM,. Dedifferentiated myxoid liposarcoma: A clinicopathological study suggesting a closer relationship between myxoid and well-differentiated liposarcoma. Histopathology 1997; 30: 457-463.
94. Willen H, Akerman M, Carlen B,. Fine needle aspiration (FNA) in the diagnosis of soft tissue tumours: A review of 22 years of experience. Cytopathology 1995; 6: 236-247.
95. Costa MJ, Campman SC, Davis RL, Howell LP,. Fine-needle aspiration cytology of sarcoma: Retrospective review of diagnostic utility and specificity. Diagn Cytopathol 1996; 15: 23-32.
96. Kilpatrick SE, Ward WG, Chauvenet AR, et al. The role of fine-needle aspiration biopsy in the initial diagnosis of pediatric bone and soft tissue tumors: An institutional experience Mod Pathol 1998; 11: 923-928.
97. Wakely PE, Kneisl JS,. Soft tissue aspiration cytopathology. Diagnostic accuracy and limitations. Cancer 2000; 90: 292-298.
98. Kilpatrick SE, Cappellari JO, Bos GD, Gold SH, Ward WG,. Is fine-needle aspiration biopsy a practical alternative to open biopsy for primary diagnosis of sarcoma? Experience with 140 patients. Am J Clin Pathol 2001; 115: 59-68.
99. Ng VY, Thomas K, Crist M, Wakely PE, Mayerson J,. Fine needle aspiration for clinical triage of extremity soft tissue masses. Clin Orthop Relat Res 2010; 468: 1120-1128.
100. Fletcher CD, Kempson RL, Weiss S,. Recommendations for the reporting of soft tissue sarcoma. Association of Directors of Anatomic and Surgical Pathology. Mod Pathol 1998; 11: 1257-1261.
101. Rougraff BT, Aboulafia A, Biermann JS, Healey J,. Biopsy of soft tissue masses. Evidence-based medicine for the musculoskeletal tumor society. Clin Orthop Relat Res 2009; 467: 2783-2791.
102. Barretina J, Taylor BS, Banjeri S, et al. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet 2010; 8: 715-721.
103. Negri T, Virdis E, Brich S, et al. Functional mapping of receptor tyrosine kinases in myxoid liposarcoma. Clin Cancer Res 2010; 16: 3581-3593.