Liposarcomas with mixed well-differentiated and pleomorphic features: A clinicopathologic study of 12 cases

American Journal of Surgical Pathology

Volumn 34, Issue 6, 2010, Pages 837-843

  Boland, Jennifer M ^a   Weiss, Sharon W ^b   Oliveira, Andre M ^a   Erickson Johnson, Michelle L ^a   Folpe, Andrew L ^a  

^a MAYO CLINIC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dedifferentiated; Liposarcoma; Pleomorphic; Well differentiated

Indexed keywords

MDM2 PROTEIN, HUMAN; PROTEIN MDM2;

ADULT; AGED; ARTICLE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENETICS; HUMAN; LIPOSARCOMA; MALE; MIDDLE AGED; PATHOLOGY; PROGNOSIS; SOFT TISSUE TUMOR;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE AMPLIFICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIPOSARCOMA; MALE; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MDM2; SOFT TISSUE NEOPLASMS;

EID: 77953080878     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e3181dbf2f7     Document Type: Article

References (33)

1. Alaggio R, Coffin CM, Weiss SW, et al. Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol. 2009;33:645-658.
2. Antonescu CR, Elahi A, Humphrey M, et al. Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas. J Mol Diagn. 2000;2:132-138.
3. Azumi N, Curtis J, Kempson RL, et al. Atypical and malignant neoplasms showing lipomatous differentiation? A study of 111 cases. Am J Surg Pathol. 1987;11:161-183.
4. Coindre JM, Pedeutour F, Aurias A. Well-differentiated and dedifferentiated liposarcomas. Virchows Arch. 2009;456:167-179.
5. de Vreeze RS, de Jong D, Nederlof PM, et al. Added value of molecular biological analysis in diagnosis and clinical management of liposarcoma: a 30-year Single-Institution Experience. Ann Surg Oncol. 2009;17:686-693.
6. Dei Tos AP, Mentzel T, Fletcher CD. Primary liposarcoma of the skin: a rare neoplasm with unusual high grade features. Am J Dermatopathol. 1998;20:332-338.
7. Domsa I, Olinici CD, Crisan D. Spermatic cord mixed liposarcoma? Case report and review of the literature. Rom J Morphol Embryol. 2008;49:105-109.
8. Downes KA, Goldblum JR, Montgomery EA, et al. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol. 2001;14:179-184.
9. Erickson-Johnson MR, Seys AR, Roth CW, et al. Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. Mod Pathol. 2009;22:1541-1547.
10. Evans HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol. 1979;3:507-523.
11. Evans HL. Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years. Am J Surg Pathol. 2007;31:1-14.
12. Evans HL, Soule EH, Winkelmann RK. Atypical lipoma, atypical intramuscular lipoma, and well differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well differentiated liposarcoma. Cancer. 1979;43:574-584.
13. Fanburg-Smith JC, Miettinen M. Liposarcoma with meningotheliallike whorls: a study of 17 cases of a distinctive histological pattern associated with dedifferentiated liposarcoma. Histopathology. 1998;33:414-424.
14. Fletcher CD, Unni KK, Mertens F. Pathology and Genetics of Tumors of Soft Tissue and Bone. Lyon, France: IARC Press; 2002.
15. Gebhard S, Coindre JM, Michels JJ, et al. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2002;26:601-616.
16. Hameed M. Pathology and genetics of adipocytic tumors. Cytogenet Genome Res. 2007;118:138-147.
17. Hornick JL, Bosenberg MW, Mentzel T, et al. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol. 2004;28:1257-1267.
18. Hosaka A, Masaki Y, Yamasaki K, et al. Retroperitoneal mixedtype liposarcoma showing features of four different subtypes. Am Surg. 2008;74:1202-1205.
19. Hosaka T, Nakashima Y, Kusuzaki K, et al. A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. J Mol Diagn. 2002;4:164-171.
20. Kim JI, Choi KU, Lee IS, et al. Gene expression in mixed type liposarcoma. Pathology. 2006;38:114-119.
21. Kindblom LG, Angervall L, Svendsen P. Liposarcoma a clinicopathologic, radiographic and prognostic study. Acta Pathol Microbiol Scand (Suppl). 1975;253:1-71.
22. Ladanyi M. The emerging molecular genetics of sarcoma translocations. Diagn Mol Pathol. 1995;4:162-173.
23. Marino-Enriquez A, Fletcher CD, dal Cin P, et al. Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathological and molecular analysis. Mod Pathol. 2010; 23 (suppl 1) : 24A.
24. Nilbert M, Rydholm A, Willen H, et al. MDM2 gene amplification correlates with ring chromosome in soft tissue tumors. Genes Chromosomes Cancer. 1994;9:261-265.
25. Oliveira AM, Nascimento AG. Pleomorphic liposarcoma. Semin Diagn Pathol. 2001;18:274-285.
26. Salemis NS, Tsiambas E, Karameris A, et al. Giant retroperitoneal liposarcoma with mixed histological pattern: a rare presentation and literature review. J Gastrointest Cancer. 2009;40:138-141.
27. Schneider-Stock R, Walter H, Radig K, et al. MDM2 amplification and loss of heterozygosity at Rb and p53 genes: no simultaneous alterations in the oncogenesis of liposarcomas. J Cancer Res Clin Oncol. 1998;124:532-540.
28. Shimada S, Ishizawa T, Ishizawa K, et al. The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers. Hum Pathol. 2006;37:1123-1129.
29. Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffinembedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31:1476-1489.
30. Suster S, Morrison C. Sclerosing poorly differentiated liposarcoma: clinicopathological, immunohistochemical and molecular analysis of a distinct morphological subtype of lipomatous tumour of soft tissue. Histopathology. 2008;52:283-293.
31. Tallini G, Akerman M, Dal Cin P, et al. Combined morphologic and karyotypic study of 28 myxoid liposarcomas. Implications for a revised morphologic typing, (a report from the CHAMP Group). Am J Surg Pathol. 1996;20:1047-1055.
32. Weaver J, Downs-Kelly E, Goldblum JR, et al. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol. 2008;21:943-949.
33. Weiss SW, Goldblum JR. Enzinger &Weiss's Soft Tissue Tumors. Philadelphia, PA: Mosby, Elsevier; 2008.