C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma

Genes Chromosomes and Cancer

Volumn 49, Issue 9, 2010, Pages 810-818

  Huang, Dali ^a   Sumegi, Janos ^b   Cin, Paola Dal ^c   Reith, John D ^d   Yasuda, Taketoshi ^a   Nelson, Marilu ^e   Muirhead, David ^a   Bridge, Julia A ^a,e  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 11 OPEN READING FRAME 95; MYOCARDIN; MYOCARDIN LIKE 2; MYOCARDIN RELATED TRANSCRIPTION FACTOR B; PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; MESSENGER RNA; MKL2 PROTEIN, HUMAN; RNA;

ACUTE MEGAKARYOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CASE REPORT; CHONDROID LIPOMA; CHROMOSOME 16P; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 13; CHROMOSOME TRANSLOCATION 16; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE LOCUS; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERPHASE; LIPOMA; MALE; MOLECULAR CLONING; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR DIAGNOSIS; CHROMOSOME 11; CHROMOSOME 16; ENZYME IMMUNOASSAY; GENE FUSION; GENE TRANSLOCATION; GENETICS; KARYOTYPING; MIDDLE AGED; YOUNG ADULT;

ADULT; AGED; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 16; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LIPOMA; MALE; MIDDLE AGED; ONCOGENE FUSION; OPEN READING FRAMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; YOUNG ADULT;

BACTERIA (MICROORGANISMS);

EID: 77955491801     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20788     Document Type: Article

References (33)

1. Ballaux F, Debiec-Rychter M, De Wever I, Sciot R. 2004. Chondroid lipoma is characterized by t(11;16)(q13;p12-13). Virchows Arch 444:208-210.
2. Balogh Z, Deák L, Sápi Z. 2008. Malignant myoepithelioma of soft tissue: A case report with cytogenetic findings. Cancer Genet Cytogenet 183:121-124. (Pubitemid 351707714)
3. Brandal P, Panagopoulos I, Bjerkehagen B, Gorunova L, Skjeldal S, Micci F, Heim S. 2008. Detection of a t(1;22)(q23; q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. Genes Chromosomes Cancer 47:558-564.
4. Brandal P, Panagopoulos I, Bjerkehagen B, Heim S. 2009. t(19; 22)(q13;q12) translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma. Genes Chromosomes Cancer 48:1051-1056.
5. Bridge JA. 2008. Advantages and limitations of cytogenetic, molecular cytogenetic, and molecular diagnostic testing in mesenchymal neoplasms. J Orthop Sci 13:273-282.
6. Buddingh EP, Naumann S, Nelson M, Neffa JR, Birch N, Bridge JA. 2003. Cytogenetic findings in benign cartilaginous neoplasms. Cancer Genet Cytogenet 141:164-168. (Pubitemid 36269219)
7. Cen B, Selvaraj A, Burgess RC, Hitzler JK, Ma Z, Morris SW, Prywes R. 2003. Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genes. Mol Cell Biol 23:6597-6608.
8. Fletcher JA, Longtine J, Wallace K, Mentzer SJ, Sugarbaker DJ. 1995. Cytogenetic and histological findings in 17 pulmonary chondroid hamartomas: Evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer 12:220-223.
9. Gisselsson D, Domanski HA, Hoglund M, Carlen B, Mertens F, Willen H, Mandahl N. 1999a. Unique cytological features and chromosome aberrations in chondroid lipoma: A case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics. Am J Surg Pathol 23:1300-1304.
10. Gisselsson D, Hoglund M, Mertens F, Dal Cin P, Mandahl N. 1999b. Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics. Am J Pathol 155:61-66.
11. Hallor KH, Teixeira MR, Fletcher CD, Bizarro S, Staaf J, Domanski HA, von Steyern FV, Panagopoulos I, Mandahl N, Mertens F. 2008. Heterogeneous genetic profiles in soft tissue myoepitheliomas. Mod Pathol 21:1311-1319.
12. Hsiao HH, Yang MY, Liu YC, Hsiao HP, Tseng SB, Chao MC, Liu TC, Lin SF. 2005. RBM15-MKL1 (OTT-MAL) fusion transcript in an adult acute myeloid leukemia patient. Am J Hematol 79:43-45.
13. ISCN. 2009. Shaffer LG, Slovak ML, Campbell LJ, editors. An International System for Human Cytogenetic Nomenclature. Basel: Karger.
14. Kindblom LG, Meis-Kindblom JM, Mandahl N. 2002. Chondroid lipoma. In: Fletcher CDM, Unni KK, Mertens F, editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon: IARC Press. p 30.
15. Kubo T, Matsui Y, Goto T, Yukata K, Yasui N. 2006. Overexpression of HMGA2-LPP fusion transcripts promotes expression of the α-2 type XI collagen gene. Biochem Biophys Res Commun 340:476-481. (Pubitemid 43021773)
16. Ladanyi M, Antonescu CR, Dal Cin P. 2008. Cytogenetic and molecular genetic pathology of soft tissue tumors. In: Weiss SW, Goldblum JR. Soft Tissue Tumors, 5th ed. Philadelphia: Mosby. pp. 73-102.
17. Logan PM, Janzen DL, O'Connell JX, Munk PL, Connell DG. 1996. Chondroid lipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol 25:592-595.
18. Ma ZG, Morris SW, Valentine V, Li M, Herbrick JA, Cui XL, Bouman D, Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GCF, Chan LC, Squire J, Scherer SW, Hitzler JK. 2001. Fusion of two novel genes, RBM15 and MKL1, in the t(1; 22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221.
19. Mandahl N, Mertens F. 2009. Soft tissue tumors. In: Heim S, Mitelman F, editors. Cancer Cytogenetics, 3rd ed. New Jersey: Wiley. pp. 675-711.
20. Meis JM, Enzinger FM. 1993. Chondroid lipoma. A unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol 17:1103-1112.
21. Mentzel T, Fletcher CD. 1998. Recent advances in soft tissue tumor diagnosis. Am J Clin Pathol 110:660-670. (Pubitemid 28491973)
22. Mertens F, Rydholm A, Brosjo O, Willen H, Mitelman F, Mandahl N. 1994. Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer 58:503-505.
23. Nishio J, Althof PA, Bailey JM, Zhou M, Neff JR, Barr FG, Parham DM, Teot L, Qualman SJ, Bridge JA. 2006. Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma. Lab Invest 86:547-556.
24. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S. 2004. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet 36:40-45.
25. Reeves R, Beckerbauer L. 2001. HMGI/Y proteins: Flexible regulators of transcription and chromatin structure. Biochim Biophys Acta 1519:13-29. (Pubitemid 32530787)
26. Sandberg AA. 2004. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Lipoma. Cancer Genet Cytogenet 150:93-115.
27. Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJ. 1995. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10:436-444.
28. Selvaraj A., Prywes R. 2003. Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation. J Biol Chem 278:41977-41987. (Pubitemid 37310461)
29. Sukov WR, Ketterling RP, Lager DJ, Carlson AW, Sinnwell JP, Chow GK, Jenkins RB, Cheville JC. 2009. CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: Frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. Hum Pathol 40:1296-1303.
30. Thomson TA, Horsman D, Bainbridge TC. 1999. Cytogenetic and cytologic features of chondroid lipoma of soft tissue. Mod Pathol 12:88-91. (Pubitemid 29059172)
31. Unni KK, Inwards CY, Bridge JA, Kindblom LG, Wold LE. 2005. Tumors of the Bones and Joints. Maryland: ARP Press.
32. van den Berg E, Zorgdrager H, Hoekstra HJ, Suurmeijer AJH. 2004. Cytogenetics of a soft tissue malignant myoepithelioma. Cancer Genet Cytogenet 151:87-89.
33. Weiss SW, Goldblum JR. 2008. Enzinger and Weiss's soft tissue tumors, 5th ed. Philadelphia: Mosby. pp 442-444.