Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in brown Norway rats

Toxicological Sciences

Volumn 120, Issue 2, 2011, Pages 331-338

  Zhu, Xu ^a   Li, Jinze ^b   Liu, Feng ^a   Uetrecht, Jack P ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b BRISTOL MYERS SQUIBB   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Animal models; Autoimmune; Idiosyncratic drug reactions; Penicillamine; Th17

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 6; MESSENGER RNA; PENICILLAMINE; TRANSFORMING GROWTH FACTOR BETA1;

ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BROWN NORWAY RAT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IDIOSYNCRATIC DRUG REACTION; MALE; NONHUMAN; PATHOGENESIS; RAT; TH17 CELL;

ANIMALIA; RATTUS NORVEGICUS;

EID: 79953099798     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq392     Document Type: Article

References (22)

1. Cua, D. J., and Tato, C. M. (2010). Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489.
2. Favilli, F., Anzilotti, C., Martinelli, L., Quattroni, P., De Martino, S., Pratesi, F., Neumann, D., Beermann, S., Novick, D., Dinarello, C. A., et al. (2009). IL-18 activity in systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1173, 301-309.
3. Ferber, I. A., Brocke, S., Taylor-Edwards, C., Ridgway, W., Dinisco, C., Steinman, L., Dalton, D., and Fathman, C. G. (1996). Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156, 5-7.
4. Goldman, M., Druet, P., and Gleichmann, E. (1991). TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 12, 223-227.
5. Jaffe, I. A. (1981). Induction of auto-immune syndromes by penicillamine therapy in rheumatoid arthritis and other diseases. Springer Semin. Immunopathol. 4, 193-207.
6. Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., and Cua, D. J. (2005). IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240.
7. Li, J., Zhu, X., Liu, F., Cai, P., Sanders, C., Lee, W. M., and Uetrecht, J. (2010). Cytokine and autoantibody patterns in acute liver failure. J. Immunotoxicol. 7, 157-164.
8. Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., and Weaver, C. T. (2006). Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441, 231-234.
9. McKenzie, B. S., Kastelein, R. A., and Cua, D. J. (2006). Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 27, 17-23.
10. Mosmann, T. R. (1992). T lymphocyte subsets, cytokines, and effector functions. Ann. N. Y. Acad. Sci. 664, 89-92.
11. Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., and Cua, D. J. (2003). Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951-1957.
12. Nowak, E. C., and Noelle, R. J. (2010). Interleukin-9 as a T helper type 17 cytokine. Immunology 131, 169-173.
13. Ouyang, W., Kolls, J. K., and Zheng, Y. (2008). The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467.
14. Sayeh, E., and Uetrecht, J. P. (2001). Factors that modify penicillamineinduced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm. Toxicology 163, 195-211.
15. Shenton, J. M., Chen, J., and Uetrecht, J. P. (2004). Animal models of idiosyncratic drug reactions. Chem. Biol. Interact. 150, 53-70.
16. Singh, V. K., Mehrotra, S., and Agarwal, S. S. (1999). The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy. Immunol. Res. 20, 147-161.
17. Tesmer, L. A., Lundy, S. K., Sarkar, S., and Fox, D. A. (2008). Th17 cells in human disease. Immunol. Rev. 223, 87-113.
18. Tournade, H., Pelletier, L., Pasquier, R., Vial, M. C., Mandet, C., and Druet, P. (1990). D-penicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity. J. Immunol. 144, 2985-2991.
19. Uetrecht, J. (2007). Idiosyncratic drug reactions: current understanding. Annu. Rev. Pharmacol. Toxicol. 47, 513-539.
20. Uetrecht, J. (2009). Immunoallergic drug-induced liver injury in humans. Semin. Liver Dis. 29, 383-392.
21. Zhou, L., Ivanov, I. I., Spolski, R., Min, R., Shenderov, K., Egawa, T., Levy, D. E., Leonard, W. J., and Littman, D. R. (2007). IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8, 967-974.
22. Zhou, L., Lopes, J. E., Chong, M. M., Ivanov, I. I., Min, R., Victora, G. D., Shen, Y., Du, J., Rubtsov, Y. P., Rudensky, A. Y., et al. (2008). TGF-betainduced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453, 236-240.