Male mice produced by in vitro culture have reduced fertility and transmit organomegaly and glucose intolerance to their male offspring

Biology of Reproduction

Volumn 87, Issue 2, 2012, Pages

  Calle, Alexandra ^a   Miranda, Alberto ^a   Fernandez Gonzalez, Raul ^a   Pericuesta, Eva ^a   Laguna, Ricardo ^a   Gutierrez Adan, Alfonso ^a  

^a INIA   (Spain)

Author keywords

Epigenetic; In vitro culture; Male fertility; Paternal transmission

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; GLUCOSE; HISTONE DEACETYLASE 1; KAP1 PROTEIN; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLASTOCYTE; BODY WEIGHT; CLINICAL FEATURE; CONTROLLED STUDY; DNA REPAIR; EPIGENETICS; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION; GENE SILENCING; GENE TRANSFER; GLUCOSE INTOLERANCE; IN VITRO OOCYTE MATURATION; MALE; MALE FERTILITY; MODIFIER GENE; MOUSE; NICK END LABELING; NONHUMAN; PHENOTYPE; POSTNATAL GROWTH; PREGNANCY; PRIORITY JOURNAL; PROGENY; SPERMATOZOON; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY;

ANIMALS; APOPTOSIS; BLASTOCYST; BLOOD GLUCOSE; BODY WEIGHT; COPULATION; EMBRYO CULTURE TECHNIQUES; EPIGENESIS, GENETIC; FEMALE; FERTILITY; GLUCOSE INTOLERANCE; IN SITU NICK-END LABELING; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; ORGAN SIZE; PHENOTYPE; RNA, MESSENGER; SPERM COUNT; TESTIS;

MUS;

EID: 84869461113     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.100743     Document Type: Article

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