Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction

Cardiovascular Research

Volumn 96, Issue 3, 2012, Pages 466-475

  Lygate, Craig A ^a   Bohl, Steffen ^a   Ten Hove, Michiel ^a   Faller, Kiterie M E ^a   Ostrowski, Philip J ^a   Zervou, Sevasti ^a   Medway, Debra J ^a   Aksentijevic, Dunja ^a   Sebag Montefiore, Liam ^a   Wallis, Julie ^a   Clarke, Kieran ^b   Watkins, Hugh ^a   Schneider, Jürgen E ^a   Neubauer, Stefan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cardiac energetics; Creatine kinase; Ischaemia; Metabolism; Myocardial stunning; Reperfusion injury

Indexed keywords

CARRIER PROTEIN; CREATINE PHOSPHATE; CREATININE; CREATININE TRANSPORTER; GLYCOGEN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVALESCENCE; CORONARY ARTERY LIGATION; ENERGY TRANSFER; HEART FAILURE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; HEART PROTECTION; HEART VENTRICLE REMODELING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; TISSUE LEVEL;

ANIMALS; CELL LINE; CREATINE; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GLYCOGEN; HEART FAILURE; MAGNETIC RESONANCE IMAGING, CINE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIAL STUNNING; MYOCARDIUM; NECROSIS; OXIDATIVE STRESS; PHOSPHOCREATINE; TIME FACTORS; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84869444711     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs272     Document Type: Article

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