MR spectroscopy in heart failure - Clinical and experimental findings

Heart Failure Reviews

Volumn 12, Issue 1, 2007, Pages 48-57

  ten Hove, Michiel ^a   Neubauer, Stefan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

1H MRS; 31P MRS; Creatine kinase; Energetics; Heart failure

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE; CREATINE KINASE; CREATINE PHOSPHATE; PHOSPHATE; PHOSPHORUS 31; PROTON;

ARTICLE; CELL PH; CORRELATION ANALYSIS; DISEASE SEVERITY; ENZYME MECHANISM; EXPERIMENTAL MODEL; HEART FAILURE; HEART MUSCLE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART STRESS; HUMAN; HYDROLYSIS; MORTALITY; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROGNOSIS; PROTON NUCLEAR MAGNETIC RESONANCE; STEADY STATE; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOLOGICAL MARKERS; CREATINE KINASE; HEART FAILURE, CONGESTIVE; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, TRANSGENIC; PHOSPHATES; PHOSPHOCREATINE;

EID: 34247385040     PISSN: 13824147     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10741-007-9003-8     Document Type: Article

References (61)

1. Garlick PB, Radda GK, Seeley PJ (1977) Phosphorus NMR studies on perfused heart. Biochem Biophys Res Commun 74:1256-1262
2. Ingwall JS (1982) Phosphorus nuclear magnetic resonance spectroscopy of cardiac and skeletal muscles. Am J Physiol 242:H729-744
3. Jacobus WE, Taylor GJt, Hollis DP, Nunnally RL (1977) Phosphorus nuclear magnetic resonance of perfused working rat hearts. Nature 265:756-758
4. Bottomley PA (1985) Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy. Science 229:769-772
5. Blackledge MJ, Rajagopalan B, Oberhaensli RD, Bolas NM, Styles P, Radda GK (1987) Quantitative studies of human cardiac metabolism by 31P rotating-frame NMR. Proc Natl Acad Sci USA 84:4283-4287
6. Bottomley PA, Weiss RG (1998) Non-invasive magnetic-resonance detection of creatine depletion in non-viable infarcted myocardium. Lancet 351:714-718
7. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM (1992) Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. Biochem J 281:21-40
8. 31P NMR magnetization transfer study. J Biol Chem 260:3512-3517
9. Meininger M, Landschutz W, Beer M, Seyfarth T, Horn M, Pabst T, Haase A, Hahn D, Neubauer S, von Kienlin M (1999) Concentrations of human cardiac phosphorus metabolites determined by SLOOP 31P NMR spectroscopy. Magn Reson Med 41:657-663
10. Neubauer S, Horn M, Cramer M, Harre K, Newell JB, Peters W, Pabst T, Ertl G, Hahn D, Ingwall JS, Kochsiek K (1997) Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation 96:2190-2196
11. Nascimben L, Ingwall JS, Pauletto P, Friedrich J, Gwathmey JK, Saks V, Pessina AC, Allen PD (1996) Creatine kinase system in failing and nonfailing human myocardium. Circulation 94:1894-1901
12. Auffermann W, Chew WM, Wolfe CL, Tavares NJ, Parmley WW, Semelka RC, Donnelly T, Chatterjee K, Higgins CB (1991) Normal and diffusely abnormal myocardium in humans: Functional and metabolic characterization with P-31 MR spectroscopy and cine MR imaging. Radiology 179:253-259
13. Bottomley PA, Hardy CJ, Roemer PB (1990) Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance. Magn Reson Med 14:425-434
14. Bottomley PA, Atalar E, Weiss RG (1996) Human cardiac high-energy phosphate metabolite concentrations by 1D-resolved NMR spectroscopy. Magn Reson Med 35:664-670
15. Neubauer S, Krahe T, Schindler R, Hillenbrand H, Entzeroth C, Horn M, Bauer WR, Stephan T, Lackner K, Haase A et al (1992) Direct measurement of spin-lattice relaxation times of phosphorus metabolites in human myocardium. Magn Reson Med 26:300-307
16. Van Dobbenburgh JO, Lekkerkerk C, Van Echteld CJA, De Beer R (1994) Saturation correction in human cardiac 31P MR spectroscopy at 1.5 T. NMR Biomed 7:218-224 218-224
17. Beer M, Spindler M, Sandstede JJ, Remmert H, Beer S, Kostler H, Hahn D (2004) Detection of myocardial infarctions by acquisition-weighted 31P-MR spectroscopy in humans. J Magn Reson Imaging 20:798-802
18. Bottomley PA (1994) MR spectroscopy of the human heart: The status and the challenges. Radiology 191:593-612
19. Nakae I, Mitsunami K, Omura T, Yabe T, Tsutamoto T, Matsuo S, Takahashi M, Morikawa S, Inubushi T, Nakamura Y, Kinoshita M, Horie M (2003) Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy. J Am Coll Cardiol 42:1587-1593
20. Ingwall JS, Kramer MF, Fifer MA, Lorell BH, Shemin R, Grossman W, Allen PD (1985) The creatine kinase system in normal and diseased human myocardium. N Engl J Med 313:1050-1054
21. Bottomley PA, Hardy C (1992) Mapping creatine kinase reaction rates in human brain and heart with 4 tesla saturation transfer 31 P NMR. J Magn Reson 99:443-448
22. Weiss RG, Gerstenblith G, Bottomley PA (2005) ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci USA 102:808-813
23. Hardy CJ, Weiss RG, Bottomley PA, Gerstenblith G (1991) Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy. Am Heart J 122:795-801
24. Masuda Y, Tateno Y, Ikehira H, Hashimoto T, Shishido F, Sekiya M, Imazeki Y, Imai H, Watanabe S, Inagaki Y (1992) High-energy phosphate metabolism of the myocardium in normal subjects and patients with various cardiomyopathies - the study using ECG gated MR spectroscopy with a localization technique. Jpn Circ J 56:620-626
25. de Roos A, Doornbos J, Luyten PR, Oosterwaal LJ, van der Wall EE, den Hollander JA (1992) Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: Assessment with proton-decoupled P-31 MR spectroscopy. J Magn Reson Imaging 2:711-719
26. Schaefer S, Gober JR, Schwartz GG, Twieg DB, Weiner MW, Massie B (1990) In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial disease. Am J Cardiol 65:1154-1161
27. Neubauer S, Krahe T, Schindler R, Horn M, Hillenbrand H, Entzeroth C, Mader H, Kromer EP, Riegger GA, Lackner K et al (1992) 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure. Circulation 86:1810-1818
28. Neubauer S, Horn M, Pabst T, Godde M, Lubke D, Jilling B, Hahn D, Ertl G (1995) Contributions of 31 P-magnetic resonance spectroscopy to the understanding of dilated heart muscle disease. Eur Heart J 16(Suppl O):115-118
29. Beer M, Seyfarth T, Sandstede J, Landschutz W, Lipke C, Kostler H, von Kienlin M, Harre K, Hahn D, Neubauer S (2002) Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31 P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol 40:1267-1274
30. Grove TH, Ackerman JJ, Radda GK, Bore PJ (1980) Analysis of rat heart in vivo by phosphorus nuclear magnetic resonance. Proc Natl Acad Sci USA 77:299-302
31. Bottomley PA, Herfkens RJ, Smith LS, Brazzamano S, Blinder R, Hedlund LW, Swain JL, Redington RW (1985) Noninvasive detection and monitoring of regional myocardial ischemia in situ using depth-resolved 31P NMR spectroscopy. Proc Natl Acad Sci USA 82:8747-8751
32. Balaban RS, Kantor HL, Katz LA, Briggs RW (1986) Relation between work and phosphate metabolite in the in vivo paced mammalian heart. Science 232:1121-1123
33. Chacko VP, Aresta F, Chacko SM, Weiss RG (2000) MRI/MRS assessment of in vivo murine cardiac metabolism, morphology, and function at physiological heart rates. Am J Physiol Heart Circ Physiol 279:H2218-2224
34. 1H-MRS in the mouse. Magn Reson Med 52:1029-1035
35. Neubauer S, Horn M, Naumann A, Tian R, Hu K, Laser M, Friedrich J, Gaudron P, Schnackerz K, Ingwall JS et al (1995) Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest 95:1092-1100
36. Murakami Y, Zhang Y, Cho YK, Mansoor AM, Chung JK, Chu C, Francis G, Ugurbil K, Bache RJ, From AH, Jerosch-Herold M, Wilke N, Zhang J (1999) Myocardial oxygenation during high work states in hearts with postinfarction remodeling. Circulation 99:942-948 942-948
37. Hugel S, Horn M, Remkes H, Dienesch C, Neubauer S (2001) Preservation of cardiac function and energy reserve by the angiotensin-converting enzyme inhibitor quinapril during postmyocardial infarction remodeling in the rat. J Cardiovasc Magn Reson 3:215-225
38. Zhang JY, Toher C, Erhard M, Zhang Y, Ugurbil K, Bache RJ, Lange T, Homans DC (1997) Relationships between myocardial bioenergetic and left ventricular function in hearts with volume-overload hypertrophy. Circulation 96:334-343
39. Tian R, Nascimben L, Kaddurah Daouk R, Ingwall JS (1996) Depletion of energy reserve via the creatine kinase reaction during the evolution of heart failure in cardiomyopathic hamsters. J Mol Cell Cardiol 28:755-765
40. Liu J, Wang C, Murakami Y, Gong G, Ishibashi Y, Prody C, Ochiai K, Bache RJ, Godinot C, Zhang J (2001) Mitochondrial ATPase and high-energy phosphates in failing hearts. Am J Physiol Heart Circ Physiol 281:H1319-1326
41. Tian R, Ingwall JS (1996) Energetic basis for reduced contractile reserve in isolated rat hearts. Am J Physiol 270:H1207-1216
42. van Deursen J, Heerschap A, Oerlemans F, Ruitenbeek W, Jap P, ter Laak H, Wieringa B (1993) Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell 74:621-631
43. 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 89:93-103
44. Van Dorsten FA, Nederhoff MGJ, Nicolay K, Van Echteld CJA (1998) 31P NMR studies of creatine kinase flux in M-creatine kinase-deficient mouse heart. Am J Physiol 275:H1191-1199
45. Saupe KW, Spindler M, Tian R, Ingwall JS (1998) Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase. Circ Res 82:898-907
46. Spindler M, Niebler R, Remkes H, Horn M, Lanz T, Neubauer S (2002) Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism. Am J Physiol Heart Circ Physiol 283:H680-687
47. Spindler M, Meyer K, Stromer H, Leupold A, Boehm E, Wagner H, Neubauer S (2004) Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis. Am J Physiol Heart Circ Physiol 287:H1039-1045
48. Nahrendorf M, Spindler M, Hu K, Bauer L, Ritter O, Nordbeck P, Quaschning T, Hiller KH, Wallis J, Ertl G, Bauer WR, Neubauer S (2005) Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction. Cardiovasc Res 65:419-427
49. Neubauer S, Hu K, Horn M, Remkes H, Hoffmann KD, Schmidt C, Schmidt TJ, Schnackerz K, Ertl G (1999) Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats. J Mol Cell Cardiol 31:1845-1855
50. Horn M, Remkes H, Stromer H, Dienesch C, Neubauer S (2001) Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction. Circulation 104:1844-1849
51. Ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, Isbrandt D, Wallis J, Neubauer S (2005) Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 111:2477-2485
52. Horn M, Remkes H, Dienesch C, Hu K, Ertl G, Neubauer S (1999) Chronic high-dose creatine feeding does not attenuate left ventricular remodeling in rat hearts post-myocardial infarction. Cardiovasc Res 43:117-124
53. Boehm E, Chan S, Monfared M, Wallimann T, Clarke K, Neubauer S (2003) Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab 284:E399-406
54. Ten Hove M, Chan S, Lygate C, Monfared M, Boehm E, Hulbert K, Watkins H, Clarke K, Neubauer S (2005) Mechanisms of creatine depletion in chronically failing rat heart. J Mol Cell Cardiol 38:309-313
55. Wallis J, Lygate CA, Fischer A, Ten Hove M, Schneider JE, Sebag-Montefiore L, Dawson D, Hulbert K, Zhang W, Zhang MH, Watkins H, Clarke K, Neubauer S (2005) Supra-normal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure - insights from creatine transporter over-expression transgenic mice. Circulation 112:3131-3139
56. Jansen MA, Van Emous JG, Nederhoff MG, Van Echteld CJ (2004) Assessment of myocardial viability by intracellular 23Na magnetic resonance imaging. Circulation 110:3457-3464
57. +]i and contractility in nonfailing and failing human myocardium. Circulation 106:447-453
58. Stanley WC, Recchia FA, Lopaschuk GD (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85:1093-1129
59. Lewandowski ED, Yu X, LaNoue KF, White LT, Doumen C, O'Donnell JM (1997) Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts. Circ Res 81:165-175
60. C NMR spectroscopy. NMR Biomed 15:222-234
61. Ardenkjaer-Larsen JH, Fridlund B, Gram A, Hansson G, Hansson L, Lerche MH, Servin R, Thaning M, Golman K (2003) Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR. Proc Natl Acad Sci USA 100:10158-10163