메뉴 건너뛰기




Volumn 106, Issue 17, 2009, Pages 7143-7148

Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism

Author keywords

Computational biology; Energy metabolism; Hypertrophy; Mitochondria

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; CREATINE;

EID: 66349111152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0812768106     Document Type: Article
Times cited : (63)

References (24)
  • 1
    • 0025343842 scopus 로고
    • Regulation of oxidative phosphorylation in the mammalian cell
    • Balaban RS (1990) Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol 258(3 Pt 1):C377-C389.
    • (1990) Am J Physiol , vol.258 , Issue.3 PART 1
    • Balaban, R.S.1
  • 2
    • 51749122229 scopus 로고    scopus 로고
    • Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts
    • Wu F, Zhang EY, Zhang J, Bache RJ, Beard DA (2008) Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts. J Physiol 586(Pt 17):4193-4208.
    • (2008) J Physiol , vol.586 , Issue.PART 17 , pp. 4193-4208
    • Wu, F.1    Zhang, E.Y.2    Zhang, J.3    Bache, R.J.4    Beard, D.A.5
  • 3
    • 3342967512 scopus 로고    scopus 로고
    • Is the failing heart energy starved? On using chemical energy to support cardiac function
    • Ingwall JS, Weiss RG (2004) Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res 95:135-145.
    • (2004) Circ Res , vol.95 , pp. 135-145
    • Ingwall, J.S.1    Weiss, R.G.2
  • 4
    • 59449085388 scopus 로고    scopus 로고
    • Energy metabolism in heart failure and remodelling
    • Ingwall JS (2009) Energy metabolism in heart failure and remodelling. Cardiovasc Res 81:412-419.
    • (2009) Cardiovasc Res , vol.81 , pp. 412-419
    • Ingwall, J.S.1
  • 5
    • 33947239659 scopus 로고    scopus 로고
    • The failing heart - an engine out of fuel
    • Neubauer S (2007) The failing heart - an engine out of fuel. N Engl J Med 356:1140-1151.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 6
    • 0033034563 scopus 로고    scopus 로고
    • Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy
    • Bache RJ, et al. (1999) Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy. Cardiovasc Res 42:616-626.
    • (1999) Cardiovasc Res , vol.42 , pp. 616-626
    • Bache, R.J.1
  • 7
    • 0028237943 scopus 로고    scopus 로고
    • Bache RJ, et al. (1994) High-energy phosphate responses to tachycardia and inotropic stimulation in left ventricular hypertrophy. Am J Physiol 266(5 Pt 2):H1959-H1970.
    • Bache RJ, et al. (1994) High-energy phosphate responses to tachycardia and inotropic stimulation in left ventricular hypertrophy. Am J Physiol 266(5 Pt 2):H1959-H1970.
  • 8
    • 0027297261 scopus 로고
    • Bioenergetic abnormalities associated with severe left ventricular hypertrophy
    • Zhang J, et al. (1993) Bioenergetic abnormalities associated with severe left ventricular hypertrophy. J Clin Invest 92:993-1003.
    • (1993) J Clin Invest , vol.92 , pp. 993-1003
    • Zhang, J.1
  • 9
    • 0035916883 scopus 로고    scopus 로고
    • High-energy phosphate metabolism and creatine kinase in failing hearts: A new porcine model
    • Ye Y, Gong G, Ochiai K, Liu J, Zhang J (2001) High-energy phosphate metabolism and creatine kinase in failing hearts: A new porcine model. Circulation 103:1570-1576.
    • (2001) Circulation , vol.103 , pp. 1570-1576
    • Ye, Y.1    Gong, G.2    Ochiai, K.3    Liu, J.4    Zhang, J.5
  • 10
    • 0022270940 scopus 로고
    • The creatine kinase system in normal and diseased human myocardium
    • Ingwall JS, et al. (1985) The creatine kinase system in normal and diseased human myocardium. N Engl J Med 313:1050-1054.
    • (1985) N Engl J Med , vol.313 , pp. 1050-1054
    • Ingwall, J.S.1
  • 11
    • 33748668461 scopus 로고    scopus 로고
    • Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium
    • Smith CS, Bottomley PA, Schulman SP, Gerstenblith G, Weiss RG (2006) Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation 114:1151-1158.
    • (2006) Circulation , vol.114 , pp. 1151-1158
    • Smith, C.S.1    Bottomley, P.A.2    Schulman, S.P.3    Gerstenblith, G.4    Weiss, R.G.5
  • 12
    • 14144256552 scopus 로고    scopus 로고
    • ATP flux through creatine kinase in the normal, stressed, and failing human heart
    • Weiss RG, Gerstenblith G, Bottomley PA (2005) ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci USA 102:808 - 813.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 808-813
    • Weiss, R.G.1    Gerstenblith, G.2    Bottomley, P.A.3
  • 13
    • 41249087880 scopus 로고    scopus 로고
    • Apoptosis: A potentially reversible, meta-stable state of the heart
    • Masri C, Chandrashekhar Y (2008) Apoptosis: A potentially reversible, meta-stable state of the heart. Heart Fail Rev 13:175-179.
    • (2008) Heart Fail Rev , vol.13 , pp. 175-179
    • Masri, C.1    Chandrashekhar, Y.2
  • 14
    • 0033517793 scopus 로고    scopus 로고
    • Downregulation of the Na(-)-creatine cotransporter in failing human myocardium and in experimental heart failure
    • Neubauer S, et al. (1999) Downregulation of the Na(-)-creatine cotransporter in failing human myocardium and in experimental heart failure. Circulation 100:1847-1850.
    • (1999) Circulation , vol.100 , pp. 1847-1850
    • Neubauer, S.1
  • 15
    • 30944442640 scopus 로고    scopus 로고
    • Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: Insights from creatine transporter-overexpressing transgenic mice
    • Wallis J, et al. (2005) Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: Insights from creatine transporter-overexpressing transgenic mice. Circulation 112:3131-3139.
    • (2005) Circulation , vol.112 , pp. 3131-3139
    • Wallis, J.1
  • 16
    • 0038299397 scopus 로고    scopus 로고
    • Oxidative capacity in failing hearts
    • Gong G, et al. (2003) Oxidative capacity in failing hearts. Am J Physiol Heart Circ Physiol 285:H541-H548.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Gong, G.1
  • 17
    • 0037127203 scopus 로고    scopus 로고
    • The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart
    • Frederich M, Balschi JA (2002) The relationship between AMP-activated protein kinase activity and AMP concentration in the isolated perfused rat heart. J Biol Chem 277:1928-1932.
    • (2002) J Biol Chem , vol.277 , pp. 1928-1932
    • Frederich, M.1    Balschi, J.A.2
  • 18
    • 0142150051 scopus 로고    scopus 로고
    • Mitochondrial formation of reactive oxygen species
    • Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552(Pt 2):335-344.
    • (2003) J Physiol , vol.552 , Issue.PART 2 , pp. 335-344
    • Turrens, J.F.1
  • 19
    • 1942437459 scopus 로고    scopus 로고
    • Myocardial density and composition: A basis for calculating intracellular metabolite concentrations
    • Vinnakota KC, Bassingthwaighte JB (2004) Myocardial density and composition: A basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol 286:H1742-H1749.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Vinnakota, K.C.1    Bassingthwaighte, J.B.2
  • 20
    • 34548297895 scopus 로고    scopus 로고
    • Computer modeling of mitochondrial tricarboxylic acid cycle, oxidative phosphorylation, metabolite transport, and electro-physiology
    • Wu F, Yang F, Vinnakota KC, Beard DA (2007) Computer modeling of mitochondrial tricarboxylic acid cycle, oxidative phosphorylation, metabolite transport, and electro-physiology. J Biol Chem 282:24525-24537.
    • (2007) J Biol Chem , vol.282 , pp. 24525-24537
    • Wu, F.1    Yang, F.2    Vinnakota, K.C.3    Beard, D.A.4
  • 21
    • 19944422074 scopus 로고    scopus 로고
    • Nitric oxide regulation of myocardial O2 consumption and HEP metabolism
    • Zhang J, et al. (2005) Nitric oxide regulation of myocardial O2 consumption and HEP metabolism. Am J Physiol Heart Circ Physiol 288:H310-H316.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Zhang, J.1
  • 22
    • 0141453881 scopus 로고    scopus 로고
    • Zhang J, From AH, Ugurbil K, Bache RJ (2003) Myocardial oxygenation and high-energy phosphate levels during KATP channel blockade. Am J Physiol Heart Circ Physiol 285:H1420-H1427.
    • Zhang J, From AH, Ugurbil K, Bache RJ (2003) Myocardial oxygenation and high-energy phosphate levels during KATP channel blockade. Am J Physiol Heart Circ Physiol 285:H1420-H1427.
  • 23
    • 0034786454 scopus 로고    scopus 로고
    • Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate
    • Ochiai K, et al. (2001) Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate. Am J Physiol Heart Circ Physiol 281:H1823-H1832.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Ochiai, K.1
  • 24
    • 18244416303 scopus 로고    scopus 로고
    • Transmural metabolic heterogeneity at high cardiac work states
    • Gong G, Ugurbil K, Zhang J (1999) Transmural metabolic heterogeneity at high cardiac work states. Am J Physiol 277(1 Pt 2):H236-H242.
    • (1999) Am J Physiol , vol.277 , Issue.1 PART 2
    • Gong, G.1    Ugurbil, K.2    Zhang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.