Thermodynamic and mechanistic insights into translesion DNA synthesis catalyzed by Y-family DNA polymerase across a bulky double-base lesion of an antitumor platinum drug

Chemistry - A European Journal

Volumn 18, Issue 48, 2012, Pages 15439-15448

  Brabec, Viktor ^a   Malina, Jaroslav ^a   Margiotta, Nicola ^b   Natile, Giovanni ^b   Kasparkova, Jana ^a  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

antitumor agents; DNA damage; double base lesion; platinum; polymerases

Indexed keywords

ANTI-TUMOR AGENTS; ANTI-TUMORS; CALORIMETRIC ANALYSIS; CARRIER LIGANDS; CATALYTIC EFFICIENCIES; DNA DAMAGES; DNA POLYMERASE; DOUBLE-BASE LESION; ERROR PRONES; HUMAN DNA POLYMERASE; MINOR GROOVES; MODEL SYSTEM; MOLECULAR ORIGINS; PLATINUM DRUGS; POLYMERASES; STERICAL EFFECT; THERMODYNAMIC FACTORS; TRANSLESION; TRANSLESION DNA SYNTHESIS; WORK SUPPORT;

CATALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; FACTOR ANALYSIS; LIGANDS; NUCLEOTIDES; PLATINUM; PLATINUM COMPOUNDS; POLYMERS; THERMODYNAMICS;

DNA;

ANTINEOPLASTIC AGENT; CISPLATIN; DNA; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; PLATINUM COMPLEX;

ARTICLE; BIOSYNTHESIS; CALORIMETRY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; DNA DAMAGE; GENETICS; HUMAN; METABOLISM; SYNTHESIS; THERMODYNAMICS;

ANTINEOPLASTIC AGENTS; CALORIMETRY; CATALYSIS; CISPLATIN; DNA; DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; HUMANS; MOLECULAR STRUCTURE; ORGANOPLATINUM COMPOUNDS; THERMODYNAMICS;

EID: 84869426962     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201202117     Document Type: Article

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