A cysteine-reactive alkyl hydroquinone modifies topoisomerase IIα, enhances DNA breakage, and induces apoptosis in cancer cells

Chemical Research in Toxicology

Volumn 25, Issue 11, 2012, Pages 2340-2351

  Lin, Ting Yu ^a   Huang, Cheng Po ^b   Au, Lo Chun ^c   Chang, Ya Wen ^a,d   Hu, Chung Yi ^a,d   Lin, Shwu Bin ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Lingzhi Biomedical Institute   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE; DNA TOPOISOMERASE (ATP HYDROLYSING); GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEPTADECATRIENYLHYDROQUINONE; HYDROQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVATION; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; PROTEIN MODIFICATION; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; CYSTEINE; DNA BREAKS; DNA BREAKS, DOUBLE-STRANDED; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; HYDROQUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84869392897     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx3002302     Document Type: Article

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